1.14.15.15 (24S)-3beta-hydroxy-24-methyl-5alpha-cholesta-8(14),22-dien-15-one + reduced adrenodoxin + H+ + O2 the substrate is a potential drug for lowering cholesterol in the treatment and/or prevention of coronary artery disease, but it is rapidly metabolized in the liver Homo sapiens ? - ? 406942 1.14.15.15 (24S)-3beta-hydroxy-24-methyl-5alpha-cholesta-8(14),22-dien-15-one + reduced adrenodoxin + H+ + O2 28-hydroxylation by CYP27A1, enzyme activity assay in presence of adrenodoxin, adrenodoxin reductase and NADPH Homo sapiens ? massspectrometric product analysis, 2 products, overview ? 406942 1.14.15.15 (25R)-5beta-cholestane-3alpha,7alpha,12alpha,27-tetraol + reduced adrenodoxin + O2 - Oryctolagus cuniculus 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid + oxidized adrenodoxin + H2O - ? 385999 1.14.15.15 1alpha-hydroxyvitamin D3 + reduced adrenodoxin + O2 25-hydroxylation Rattus norvegicus 1alpha,25-dihydroxyvitamin D3 + oxidized adrenodoxin + H2O - ? 288580 1.14.15.15 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al + reduced adrenodoxin + O2 - Oryctolagus cuniculus 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid + oxidized adrenodoxin + H2O - ? 387400 1.14.15.15 3beta-hydroxy-5alpha-cholest-8(14)-en-15-one + reduced adrenodoxin + H+ + O2 the substrate is a potential drug for lowering cholesterol in the treatment and/or prevention of coronary artery disease, but it is rapidly metabolized in the liver Homo sapiens ? - ? 407055 1.14.15.15 3beta-hydroxy-5alpha-cholest-8(14)-en-15-one + reduced adrenodoxin + H+ + O2 28-hydroxylation by CYP27A1, enzyme activity assay in presence of adrenodoxin, adrenodoxin reductase and NADPH Homo sapiens ? massspectrometric product analysis, 2 products, overview ? 407055 1.14.15.15 5-cholestene-3beta,7alpha-diol + reduced adrenodoxin + O2 - Oryctolagus cuniculus 5-cholestene-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O - ? 386155 1.14.15.15 5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + reduced adrenodoxin + O2 - Homo sapiens 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + oxidized adrenodoxin + H2O - ? 257109 1.14.15.15 5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + reduced adrenodoxin + O2 - Rattus norvegicus 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + oxidized adrenodoxin + H2O - ? 257109