5.3.3.19	3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate	-	Bacillus subtilis	(3Z)-3-[(4R)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate	-	?	429156	
5.3.3.19	3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate	the enzyme from the bacterium Bacillus subtilis is involved in the biosynthesis of the nonproteinogenic amino acid tetrahydrotyrosine a component of the dipeptide antibiotic bacilysin	Bacillus subtilis	(3Z)-3-[(4R)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate	-	?	429156	
5.3.3.19	3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate	3-[(4S)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate also undergoes a nonenzymatic isomerization	Bacillus subtilis	(3Z)-3-[(4R)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate	-	?	429156	
5.3.3.19	3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate	nonenzymatic isomerization gives (3E)-3-[(4S)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate and (3Z)-3-[(4S)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate in the ratio 50:1. Isomerization by BacB gives a 3:1 mixture of the E- and Z-isomers	Bacillus subtilis	(3Z)-3-[(4R)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate	-	?	429156	
5.3.3.19	3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate	the enzyme generates a mixture of 3E- and 3Z-isomers. It equilibrates the more stable 3E and less stable 3Z geometric isomers to give up to 25% of the 3Z isomer, which on subsequent reduction by BacG gives the desired 4S stereochemistry of the cyclohexanol scaffold	Bacillus subtilis	(3Z)-3-[(4R)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate	-	?	429156	
5.3.3.19	3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate	the enzyme from the bacterium Bacillus subtilis is involved in the biosynthesis of the nonproteinogenic amino acid tetrahydrotyrosine a component of the dipeptide antibiotic bacilysin	Bacillus subtilis 168	(3Z)-3-[(4R)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate	-	?	429156	
5.3.3.19	3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate	3-[(4S)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate also undergoes a nonenzymatic isomerization	Bacillus subtilis 168	(3Z)-3-[(4R)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate	-	?	429156	
5.3.3.19	3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate	nonenzymatic isomerization gives (3E)-3-[(4S)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate and (3Z)-3-[(4S)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate in the ratio 50:1. Isomerization by BacB gives a 3:1 mixture of the E- and Z-isomers	Bacillus subtilis 168	(3Z)-3-[(4R)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate	-	?	429156	
5.3.3.19	3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate	the enzyme generates a mixture of 3E- and 3Z-isomers. It equilibrates the more stable 3E and less stable 3Z geometric isomers to give up to 25% of the 3Z isomer, which on subsequent reduction by BacG gives the desired 4S stereochemistry of the cyclohexanol scaffold	Bacillus subtilis 168	(3Z)-3-[(4R)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate	-	?	429156	
5.3.3.19	3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate	-	Bacillus subtilis 168	(3Z)-3-[(4R)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate	-	?	429156