2.5.1.109 dimethylallyl diphosphate + (R)-benzodiazepinedione low activity, (R)-benzodiazepinedione consists of a tryptophanyl and an anthranilyl moiety Aspergillus terreus diphosphate + ? - ? 437399 2.5.1.109 dimethylallyl diphosphate + (S)-benzodiazepinedione best substrate, (S)-benzodiazepinedione consists of a tryptophanyl and an anthranilyl moiety Aspergillus terreus diphosphate + ? - ? 437400 2.5.1.109 dimethylallyl diphosphate + benzodiazepinedione best substrate, active only with benzodiazepinedione consisting of a D-tryptophanyl and an anthranilyl moiety, poor activity with the L-Tryp isomer Aspergillus terreus diphosphate + ? - ? 437443 2.5.1.109 dimethylallyl diphosphate + brevianamide F - Aspergillus versicolor diphosphate + deoxybrevianamide E - ? 421952 2.5.1.109 dimethylallyl diphosphate + brevianamide F - Aspergillus sp. MF297-2 diphosphate + deoxybrevianamide E - ? 421952 2.5.1.109 dimethylallyl diphosphate + brevianamide F the enzyme is involved in the alkaloid biosynthetic pathway Aspergillus sp. diphosphate + deoxybrevianamide E - ? 421952 2.5.1.109 dimethylallyl diphosphate + brevianamide F the enzyme accepts a broad range of tryptophan-containing cyclic dipeptides, no activity with farnesyl diphosphate and geranyl diphosphate Aspergillus versicolor diphosphate + deoxybrevianamide E - ? 421952 2.5.1.109 dimethylallyl diphosphate + brevianamide F the enzyme is specific for brevianamide F i.e. (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione Aspergillus sp. diphosphate + deoxybrevianamide E deoxybrevianamide E i.e. (3S,8aS)-3-[[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]methyl]-octahydropyrrolo[1,2-a]piperazine-1,4-dione ? 421952 2.5.1.109 dimethylallyl diphosphate + brevianamide F i.e. cyclo-L-Trp-L-Pro Aspergillus versicolor diphosphate + deoxybrevianamide E - ? 421952 2.5.1.109 dimethylallyl diphosphate + brevianamide F i.e. cyclo-L-Trp-L-Pro, conversion yield of 66% Aspergillus sp. MF297-2 diphosphate + deoxybrevianamide E - ? 421952