1.2.1.3 (2E)-4-hydroxy-2-nonenal + NAD+ + H2O - Rattus norvegicus (2E)-4-hydroxy-2-nonenoic acid + NADH + H+ - ? 399143 1.2.1.3 (2E)-4-hydroxy-2-nonenal + NAD+ + H2O - Bos taurus (2E)-4-hydroxy-2-nonenoic acid + NADH + H+ - ? 399143 1.2.1.3 (E)-2-nonenal + NAD+ + H2O - Arabidopsis thaliana (E)-non-2-enoate + NADH + H+ - ? 427130 1.2.1.3 (R)-N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b] thiophene-2-carboxamide + H2O + O2 i.e. GDC-0834, a Bruton's tyrosine kinase inhibitor, a potential treatment of rheumatoid arthritis. GDC-0834 Homo sapiens ? compound is extensively metabolized by amide hydrolysis by both aldehyde oxidase and carboxylesterase ? 438562 1.2.1.3 (R)-trans-4-hydroxy-2-nonenal + NAD+ + H2O - Rattus norvegicus (2E,4R)-4-hydroxynon-2-enoic acid + NADH + H+ - ? 399212 1.2.1.3 (R)-trans-4-hydroxy-2-nonenal + NAD+ + H2O ALDH5A enantioselectively oxidizes (R)-trans-4-hydroxy-2-nonenal Rattus norvegicus (2E,4R)-4-hydroxynon-2-enoic acid + NADH + H+ - ? 399212 1.2.1.3 (S)-trans-4-hydroxy-2-nonenal + NAD+ + H2O - Rattus norvegicus (2E,4S)-4-hydroxynon-2-enoic acid + NADH + H+ - ? 399238 1.2.1.3 1,3-dihydroxyacetone + NAD+ + H2O 53.93% activity compared to acetaldehyde Sulfurisphaera tokodaii ? + NADH + H+ - ? 422249 1.2.1.3 1-formyl-6-methylpyrene + NAD+ - Homo sapiens 6-methylpyrene 1-carboxylate + NADH + H+ - ? 395244 1.2.1.3 1-formyl-6-methylpyrene + NAD+ + H2O - Homo sapiens 6-methylpyrene-1-carboxylic acid + NADH + H+ - ? 399268