1.1.1.423	(-)-(1R,2S)-ephedrine + NAD+	-	Arthrobacter sp. TS-15	(S)-2-methylamino-1-phenylpropan-1-one + NADH + H+	-	?	449073	
1.1.1.423	(-)-(1R,2S)-ephedrine + NAD+	the enzyme acts on a broad range of different aryl-alkyl ketones, such as haloketones, ketoamines, diketones, and ketoesters. It accepts various types of aryl groups including phenyl-, pyridyl-, thienyl-, and furyl-rings, but the presence of an aromatic ring is essential for the activity. In addition, the presence of a functional group on the alkyl chain, such as an amine, a halogen, or a ketone, is also crucial. The enzyme exhibits a strict Prelog enantioselectivity. When acting on diketones, it catalyses the reduction of only the keto group closest to the ring, with no further reduction to the diol. (-)-(1R,2S)-ephedrine i.e. (1R,2S)-1-phenyl-1-hydroxy-2-methylaminopropane. (S)-2-methylamino-1-phenylpropan-1-one i.e. (S)-methcathinone	Arthrobacter sp. TS-15	(S)-2-methylamino-1-phenylpropan-1-one + NADH + H+	-	?	449073	
1.1.1.423	(-)-(1R,2S)-ephedrine + NAD+	the enzyme exhibits a strict enantioselectivity for the oxidation of (-)-(1R,2S)-ephedrine and (R,R)-(-)-pseudoephedrine	Arthrobacter sp. TS-15	(S)-2-methylamino-1-phenylpropan-1-one + NADH + H+	-	?	449073	
1.1.1.423	(4-chlorophenyl)-2-pyridinylmethanone + NAD+	specifc activity: 1.74 U/mg. Product: 70% (S) enantiomeric excess	Arthrobacter sp. TS-15	(S)-(4-chlorophenyl)(pyridin-2-yl)methanol + NADH + H+	-	?	454745	
1.1.1.423	(4-chlorophenyl)-2-pyridinylmethanone + NADH + H+	2.7% of the activity as compared to 1-phenyl-1,2-propanedione. The (R)-enantiomer is formed with 70% enantiomeric excess	Arthrobacter sp. TS-15	(R)-(4-chlorophenyl)(pyridin-2-yl)methanol + NAD+	-	?	449082	
1.1.1.423	(R,R)-(-)-pseudoephedrine + NAD+	the enzyme exhibits a strict enantioselectivity for the oxidation of (-)-(1R,2S)-ephedrine and (R,R)-(-)-pseudoephedrine	Arthrobacter sp. TS-15	? + NADH + H+	-	?	454757	
1.1.1.423	1,2-indandione + NAD+	specifc 50.05 U/mg	Arthrobacter sp. TS-15	? + NADH + H+	-	?	454776	
1.1.1.423	1,2-indanedione + NADH + H+	78.1% of the activity as compared to 1-phenyl-1,2-propanedione	Arthrobacter sp. TS-15	1-hydroxy-1,3-dihydro-2H-inden-2-one + NAD+	-	?	449133	
1.1.1.423	1,2-naphthoquinone + NAD+	specifc activity: 13.89 U/mg	Arthrobacter sp. TS-15	? + NADH + H+	-	?	454777	
1.1.1.423	1,2-naphthoquinone + NADH + H+	21.7% of the activity as compared to 1-phenyl-1,2-propanedione	Arthrobacter sp. TS-15	1-hydroxynaphthalen-2(1H)-one + NAD+	-	?	449135