7.4.2.1 ATP + H2O + acidic amino acid/out crucial role for the uptake of amino acids into the endosperm and supplying the developing embryo with amino acids during early embryogenesis Arabidopsis thaliana ADP + phosphate + acidic amino acid/in - ? 394730 7.4.2.1 ATP + H2O + alpha-aminoadipic acid-[polar amino acid-binding protein][side 1] - Penicillium chrysogenum ADP + phosphate + alpha-aminoadipic acid[side 2] + [polar amino acid-binding protein][side 1] - ? 453806 7.4.2.1 ATP + H2O + alpha-aminoadipic acid-[polar amino acid-binding protein][side 1] - Penicillium chrysogenum Wisconsin 54-1255 ADP + phosphate + alpha-aminoadipic acid[side 2] + [polar amino acid-binding protein][side 1] - ? 453806 7.4.2.1 ATP + H2O + alpha-aminoisobutyric acid/out - Rhizobium leguminosarum ADP + phosphate + alpha-aminoisobutyric acid/in - ? 372453 7.4.2.1 ATP + H2O + amino acid/out acidic and neutral polar amino acid uptake, essential for diazotropic physiology of the bacterium, transports Asp, Glu, Asn, Gln, Met, Thr, Ala, Ser, Gly, and His Anabaena sp. ADP + phosphate + amino acid/in - ? 394732 7.4.2.1 ATP + H2O + amino acid/out amino acid uptake, catalyzes the transport of all the D- and L-isomers of the amino acids normally found in proteins Saccharomyces cerevisiae ADP + phosphate + amino acid/in - ? 394732 7.4.2.1 ATP + H2O + amino acid/out essential for basic amino acid uptake, transports Lys, Arg, Orn, His, and Gln Anabaena sp. ADP + phosphate + amino acid/in - ? 394732 7.4.2.1 ATP + H2O + betaine/out - Sinorhizobium meliloti ADP + phosphate + betaine/in - ? 141440 7.4.2.1 ATP + H2O + betaine/out the histidine transport system Hut is also involved in proline and betaine uptake Sinorhizobium meliloti ADP + phosphate + betaine/in - ? 141440 7.4.2.1 ATP + H2O + citrulline/out - Saccharomyces cerevisiae ADP + phosphate + citrulline/in - ? 404390 7.4.2.1 ATP + H2O + glycine/out - Saccharomyces cerevisiae ADP + phosphate + glycine/in - ? 394740 7.4.2.1 ATP + H2O + His/out - Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphate + His/in - ? 165499 7.4.2.1 ATP + H2O + His/out - Sinorhizobium meliloti ADP + phosphate + His/in - ? 165499 7.4.2.1 ATP + H2O + His/out - Escherichia coli ADP + phosphate + His/in - ? 165499 7.4.2.1 ATP + H2O + His/out the histidine transport system Hut is also involved in proline and betaine uptake Sinorhizobium meliloti ADP + phosphate + His/in - ? 165499 7.4.2.1 ATP + H2O + histidine/out - Homo sapiens ADP + phosphate + histidine/in - ? 370872 7.4.2.1 ATP + H2O + L-alanine/out - Saccharomyces cerevisiae ADP + phosphate + L-alanine/in - ? 372459 7.4.2.1 ATP + H2O + L-alanine/out - Arabidopsis thaliana ADP + phosphate + L-alanine/in - ? 372459 7.4.2.1 ATP + H2O + L-alanine/out - Rhizobium leguminosarum ADP + phosphate + L-alanine/in - ? 372459 7.4.2.1 ATP + H2O + L-alanine/out - Uromyces viciae-fabae ADP + phosphate + L-alanine/in - ? 372459 7.4.2.1 ATP + H2O + L-alanine/out - Arabidopsis thaliana Col-0 ADP + phosphate + L-alanine/in - ? 372459 7.4.2.1 ATP + H2O + L-Arg/out - Anabaena sp. ADP + phosphate + L-Arg/in - ? 165507 7.4.2.1 ATP + H2O + L-Arg/out the histidine-binding protein HisJ binds L-His and L-Arg tightly and L-Lys and L-Orn less tightly Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphate + L-Arg/in - ? 165507 7.4.2.1 ATP + H2O + L-arginine-[L-arginine -binding protein][side 1] - Aedes aegypti ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1] - ? 444230 7.4.2.1 ATP + H2O + L-arginine-[L-arginine-binding protein][side 1] - Leishmania mexicana ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1] - ? 444231 7.4.2.1 ATP + H2O + L-arginine-[L-arginine-binding protein][side 1] - Leishmania amazonensis ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1] - ? 444231 7.4.2.1 ATP + H2O + L-arginine-[L-arginine-binding protein][side 1] - Leishmania major ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1] - ? 444231 7.4.2.1 ATP + H2O + L-arginine-[L-arginine-binding protein][side 1] - Leishmania braziliensis ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1] - ? 444231 7.4.2.1 ATP + H2O + L-arginine-[L-arginine-binding protein][side 1] - Leishmania tropica ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1] - ? 444231 7.4.2.1 ATP + H2O + L-arginine-[L-arginine-binding protein][side 1] - Leishmania donovani ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1] - ? 444231 7.4.2.1 ATP + H2O + L-arginine-[L-arginine-binding protein][side 1] - Leishmania infantum ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1] - ? 444231 7.4.2.1 ATP + H2O + L-arginine-[L-arginine-binding protein][side 1] - Leishmania guyanensis ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1] - ? 444231 7.4.2.1 ATP + H2O + L-arginine-[L-arginine-binding protein][side 1] - Leishmania lainsoni ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1] - ? 444231 7.4.2.1 ATP + H2O + L-arginine-[L-arginine-binding protein][side 1] - Leishmania naiffi ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1] - ? 444231 7.4.2.1 ATP + H2O + L-arginine-[L-arginine-binding protein][side 1] - Leishmania shawi ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1] - ? 444231 7.4.2.1 ATP + H2O + L-arginine-[L-arginine-binding protein][side 1] preferred amino acid Aedes aegypti ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1] - ? 444231 7.4.2.1 ATP + H2O + L-arginine-[L-arginine-binding protein][side 1] - Leishmania amazonensis MHOM/BR/1973/2269 ADP + phosphate + L-arginine[side 2] + [L-arginine-binding protein][side 1] - ? 444231 7.4.2.1 ATP + H2O + L-arginine/out - Saccharomyces cerevisiae ADP + phosphate + L-arginine/in - ? 388054 7.4.2.1 ATP + H2O + L-Asp/out - Arabidopsis thaliana ADP + phosphate + L-Asp/in - ? 394742 7.4.2.1 ATP + H2O + L-Asp/out - Anabaena sp. ADP + phosphate + L-Asp/in - ? 394742 7.4.2.1 ATP + H2O + L-asparagine-[L-asparagine-binding protein][side 1] - Pisum sativum ADP + phosphate + L-asparagine[side 2] + [L-asparagine-binding protein][side 1] - ? 444232 7.4.2.1 ATP + H2O + L-asparagine-[L-asparagine-binding protein][side 1] - Lactococcus lactis ADP + phosphate + L-asparagine[side 2] + [L-asparagine-binding protein][side 1] - ? 444232 7.4.2.1 ATP + H2O + L-asparagine-[L-asparagine-binding protein][side 1] - Lactococcus lactis NZ9000 ADP + phosphate + L-asparagine[side 2] + [L-asparagine-binding protein][side 1] - ? 444232 7.4.2.1 ATP + H2O + L-asparagine/out - Uromyces viciae-fabae ADP + phosphate + L-asparagine - ? 388055 7.4.2.1 ATP + H2O + L-aspartate-[L-aspartate-binding protein][side 1] - Sus scrofa ADP + phosphate + L-aspartate[side 2] + [L-aspartate-binding protein][side 1] - ? 445052 7.4.2.1 ATP + H2O + L-aspartate/out - Arabidopsis thaliana ADP + phosphate + L-aspartate/in - ? 420331 7.4.2.1 ATP + H2O + L-aspartate/out - Arabidopsis thaliana Col-0 ADP + phosphate + L-aspartate/in - ? 420331 7.4.2.1 ATP + H2O + L-citrulline-[L-citrulline-binding protein][side 1] - Aedes aegypti ADP + phosphate + L-citrulline[side 2] + [L-citrulline-binding protein][side 1] - ? 445053 7.4.2.1 ATP + H2O + L-citrulline/out - Saccharomyces cerevisiae ADP + phosphate + L-citrulline/in - ? 396502 7.4.2.1 ATP + H2O + L-cysteine/out - Uromyces viciae-fabae ADP + phosphate + L-cysteine/in - ? 388056 7.4.2.1 ATP + H2O + L-Gln/out - Anabaena sp. ADP + phosphate + L-Gln/in - ? 394743 7.4.2.1 ATP + H2O + L-Glu/out - Arabidopsis thaliana ADP + phosphate + L-Glu/in - ? 394744 7.4.2.1 ATP + H2O + L-Glu/out - Anabaena sp. ADP + phosphate + L-Glu/in - ? 394744 7.4.2.1 ATP + H2O + L-glutamate-[L-glutamate-binding protein][side 1] - Fusarium fujikuroi ADP + phosphate + L-glutamate[side 2] + [L-glutamate-binding protein][side 1] - ? 444233 7.4.2.1 ATP + H2O + L-glutamate-[L-glutamate-binding protein][side 1] - Synechococcus elongatus ADP + phosphate + L-glutamate[side 2] + [L-glutamate-binding protein][side 1] - ? 444233 7.4.2.1 ATP + H2O + L-glutamate-[L-glutamate-binding protein][side 1] - Nostoc sp. PCC 7120 = FACHB-418 ADP + phosphate + L-glutamate[side 2] + [L-glutamate-binding protein][side 1] - ? 444233 7.4.2.1 ATP + H2O + L-glutamate-[L-glutamate-binding protein][side 1] - Sus scrofa ADP + phosphate + L-glutamate[side 2] + [L-glutamate-binding protein][side 1] - ? 444233 7.4.2.1 ATP + H2O + L-glutamate-[L-glutamate-binding protein][side 1] - Synechococcus elongatus PCC 7942 ADP + phosphate + L-glutamate[side 2] + [L-glutamate-binding protein][side 1] - ? 444233 7.4.2.1 ATP + H2O + L-glutamate-[L-glutamate-binding protein][side 1] - Fusarium fujikuroi IMI58289 ADP + phosphate + L-glutamate[side 2] + [L-glutamate-binding protein][side 1] - ? 444233 7.4.2.1 ATP + H2O + L-glutamate/out - Saccharomyces cerevisiae ADP + phosphate + L-glutamate/in - ? 372460 7.4.2.1 ATP + H2O + L-glutamate/out - Arabidopsis thaliana ADP + phosphate + L-glutamate/in - ? 372460 7.4.2.1 ATP + H2O + L-glutamate/out - Rhizobium leguminosarum ADP + phosphate + L-glutamate/in - ? 372460 7.4.2.1 ATP + H2O + L-glutamate/out - Uromyces viciae-fabae ADP + phosphate + L-glutamate/in - ? 372460 7.4.2.1 ATP + H2O + L-glutamate/out - Arabidopsis thaliana Col-0 ADP + phosphate + L-glutamate/in - ? 372460 7.4.2.1 ATP + H2O + L-glutamic acid-[L-glutamic acid-binding protein][side 1] - Lactococcus lactis ADP + phosphate + L-glutamic acid[side 2] + [L-glutamic acid-binding protein][side 1] - ? 445054 7.4.2.1 ATP + H2O + L-glutamic acid-[L-glutamic acid-binding protein][side 1] - Lactococcus lactis NZ9000 ADP + phosphate + L-glutamic acid[side 2] + [L-glutamic acid-binding protein][side 1] - ? 445054 7.4.2.1 ATP + H2O + L-glutamine-[L-glutamine-binding protein][side 1] - Arabidopsis thaliana ADP + phosphate + L-glutamine[side 2] + [L-glutamine-binding protein][side 1] - ? 444234 7.4.2.1 ATP + H2O + L-glutamine-[L-glutamine-binding protein][side 1] - Fusarium fujikuroi ADP + phosphate + L-glutamine[side 2] + [L-glutamine-binding protein][side 1] - ? 444234 7.4.2.1 ATP + H2O + L-glutamine-[L-glutamine-binding protein][side 1] the enzyme is specific for glutamine Acyrthosiphon pisum ADP + phosphate + L-glutamine[side 2] + [L-glutamine-binding protein][side 1] - ? 444234 7.4.2.1 ATP + H2O + L-glutamine-[L-glutamine-binding protein][side 1] the enzyme is the only transport system for L-glutamine but not for L-glutamic acid and L-asparagine Lactococcus lactis ADP + phosphate + L-glutamine[side 2] + [L-glutamine-binding protein][side 1] - ? 444234 7.4.2.1 ATP + H2O + L-glutamine-[L-glutamine-binding protein][side 1] the enzyme is the only transport system for L-glutamine but not for L-glutamic acid and L-asparagine Lactococcus lactis NZ9000 ADP + phosphate + L-glutamine[side 2] + [L-glutamine-binding protein][side 1] - ? 444234 7.4.2.1 ATP + H2O + L-glutamine-[L-glutamine-binding protein][side 1] - Fusarium fujikuroi IMI58289 ADP + phosphate + L-glutamine[side 2] + [L-glutamine-binding protein][side 1] - ? 444234 7.4.2.1 ATP + H2O + L-glutamine/out - Uromyces viciae-fabae ADP + phosphate + L-glutamine/in - ? 388057 7.4.2.1 ATP + H2O + L-glutamine/out - Arabidopsis thaliana ADP + phosphate + glutamine/in - ? 420332 7.4.2.1 ATP + H2O + L-histidine-[L-histidine-binding protein][side 1] - Saccharomyces cerevisiae ADP + phosphate + L-histidine[side 2] + [L-histidine-binding protein][side 1] - ? 444235 7.4.2.1 ATP + H2O + L-histidine-[L-histidine-binding protein][side 1] - Aedes aegypti ADP + phosphate + L-histidine[side 2] + [L-histidine-binding protein][side 1] - ? 444235 7.4.2.1 ATP + H2O + L-histidine-[L-histidine-binding protein][side 1] - Saccharomyces cerevisiae BY4741 ADP + phosphate + L-histidine[side 2] + [L-histidine-binding protein][side 1] - ? 444235 7.4.2.1 ATP + H2O + L-histidine/out - Arabidopsis thaliana ADP + phosphate + L-histidine/in - ? 372461 7.4.2.1 ATP + H2O + L-histidine/out - Rhizobium leguminosarum ADP + phosphate + L-histidine/in - ? 372461 7.4.2.1 ATP + H2O + L-histidine/out - Arabidopsis thaliana Col-0 ADP + phosphate + L-histidine/in - ? 372461 7.4.2.1 ATP + H2O + L-Leu/out - Saccharomyces cerevisiae ADP + phosphate + L-Leu/in - ? 396503 7.4.2.1 ATP + H2O + L-leucine/out - Saccharomyces cerevisiae ADP + phosphate + L-leucine/in - ? 372462 7.4.2.1 ATP + H2O + L-leucine/out - Rhizobium leguminosarum ADP + phosphate + L-leucine/in - ? 372462 7.4.2.1 ATP + H2O + L-leucine/out - Uromyces viciae-fabae ADP + phosphate + L-leucine/in - ? 372462 7.4.2.1 ATP + H2O + L-Lys/out - Anabaena sp. ADP + phosphate + L-Lys/in - ? 165508 7.4.2.1 ATP + H2O + L-Lys/out the histidine-binding protein HisJ binds L-His and L-Arg tightly and L-Lys and L-Orn less tightly Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphate + L-Lys/in - ? 165508 7.4.2.1 ATP + H2O + L-lysine-[L-lysine-binding protein][side 1] - Aedes aegypti ADP + phosphate + L-lysine[side 2] + [L-lysine-binding protein][side 1] - ? 445056 7.4.2.1 ATP + H2O + L-lysine/out - Escherichia coli ADP + phosphate + L-lysine/in - ? 419359 7.4.2.1 ATP + H2O + L-lysine/out - Saccharomyces cerevisiae ADP + phosphate + L-lysine/in - ? 419359 7.4.2.1 ATP + H2O + L-lysine/out - Leishmania donovani ADP + phosphate + L-lysine/in - ? 419359 7.4.2.1 ATP + H2O + L-lysine/out - Trypanosoma cruzi ADP + phosphate + L-lysine/in - ? 419359 7.4.2.1 ATP + H2O + L-methionine/out - Uromyces viciae-fabae ADP + phosphate + L-methionine/in - ? 388058 7.4.2.1 ATP + H2O + L-methionine/out transported to a lesser extent than branched-chain amino acids Lactococcus lactis ADP + phosphate + L-methionine/in - ? 388058 7.4.2.1 ATP + H2O + L-methionine/out transported to a lesser extent than branched-chain amino acids Lactococcus lactis MG1361 derivates ADP + phosphate + L-methionine/in - ? 388058 7.4.2.1 ATP + H2O + L-Orn/out the histidine-binding protein HisJ binds L-His and L-Arg tightly and L-Lys and L-Orn less tightly Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphate + L-Orn/in - ? 165509 7.4.2.1 ATP + H2O + L-ornithine-[L-ornithine-binding protein][side 1] - Aedes aegypti ADP + phosphate + L-ornithine[side 2] + [L-ornithine-binding protein][side 1] - ? 445057 7.4.2.1 ATP + H2O + L-phenylalanine/out - Saccharomyces cerevisiae ADP + phosphate + L-phenylalanine/in - ? 420334 7.4.2.1 ATP + H2O + L-threonine/out - Saccharomyces cerevisiae ADP + phosphate + L-threonine/in - ? 420335 7.4.2.1 ATP + H2O + neutral amino acid/out - Arabidopsis thaliana ADP + phosphate + neutral amino acid/in - ? 420339 7.4.2.1 ATP + H2O + polar amino acid-[polar amino acid-binding protein][side 1] - Arabidopsis thaliana ADP + phosphate + polar amino acid[side 2] + [polar amino acid-binding protein][side 1] - ? 444252 7.4.2.1 ATP + H2O + polar amino acid/out - Saccharomyces cerevisiae ADP + phosphate + polar amino acid/in - ? 402484 7.4.2.1 ATP + H2O + polar amino acid/out - Leishmania donovani ADP + phosphate + polar amino acid/in - ? 402484 7.4.2.1 ATP + H2O + polar amino acid/out - Trypanosoma cruzi ADP + phosphate + polar amino acid/in - ? 402484 7.4.2.1 ATP + H2O + polar amino acid/out Ser388 and Val389 are exposed into the amino acid binding site for transport, also used by agonist action for signaling Saccharomyces cerevisiae ADP + phosphate + polar amino acid/in - ? 402484 7.4.2.1 ATP + H2O + Pro/out - Sinorhizobium meliloti ADP + phosphate + Pro/in - ? 165500 7.4.2.1 ATP + H2O + Pro/out the histidine transport system Hut is also involved in proline and betaine uptake Sinorhizobium meliloti ADP + phosphate + Pro/in - ? 165500 7.4.2.1 CTP + H2O + His/out dimeric HisP protein with a carboxy-terminal extension of 8 amino acids, 50% of the ATPase activity with ATP Salmonella enterica subsp. enterica serovar Typhimurium CDP + phosphate + His/in - ? 165503 7.4.2.1 GTP + H2O + His/out dimeric HisP protein with a carboxy-terminal extension of 8 amino acids, 53% of the ATPase activity with ATP Salmonella enterica subsp. enterica serovar Typhimurium GDP + phosphate + His/in - ? 165502 7.4.2.1 additional information broad specificity for polar amino acids Sinorhizobium meliloti ? - ? 89 7.4.2.1 additional information broad specificity for polar amino acids Escherichia coli ? - ? 89 7.4.2.1 additional information broad specificity for polar amino acids Pseudomonas fluorescens ? - ? 89 7.4.2.1 additional information broad specificity for polar amino acids Rhodobacter capsulatus ? - ? 89 7.4.2.1 additional information broad specificity for polar amino acids Pectobacterium carotovorum ? - ? 89 7.4.2.1 additional information broad specificity for polar amino acids Citrobacter freundii ? - ? 89 7.4.2.1 additional information broad specificity for polar amino acids Rhizobium leguminosarum ? - ? 89 7.4.2.1 additional information contributes to the alpha-aminoadipic acid flux Penicillium chrysogenum ? - ? 89 7.4.2.1 additional information specifically transports branched-chain amino acids Lactococcus lactis ? - ? 89 7.4.2.1 additional information Gap1 is a transporting amino acid transceptor that triggers the activation of the protein kinase A pathway Saccharomyces cerevisiae ? - ? 89 7.4.2.1 additional information Gap1p transports all naturally occurring amino acids Saccharomyces cerevisiae ? - ? 89 7.4.2.1 additional information 1H, 13C, and 15N backbone resonance assignments for apo HisJ and holo HisJ from Escherichia coli. Structural information about the interactions between HisJ and HisQM and to clarify the mechanism of the histidine transfer from the periplasm to the cytoplasm Escherichia coli ? - ? 89 7.4.2.1 additional information LHT1 displays high affinity for neutral amino acids, L-His, and acidic amino acids. Amino acid permease 1 mediates uptake of several neutral amino acids as well as L-Glu and L-His but, similar to LHT1, activity for L-Arg and L-Lys is not detected Arabidopsis thaliana ? - ? 89 7.4.2.1 additional information specificity of L-lysine transport in wild-type cells and in recombinantly parasite AAP7 expressing yeast 22DELTA7AA cells, overview Leishmania donovani ? - ? 89 7.4.2.1 additional information specificity of L-lysine transport in wild-type cells, overview Trypanosoma cruzi ? - ? 89 7.4.2.1 additional information the GTG motif of Gap1p is involved in amino acid binding Saccharomyces cerevisiae ? - ? 89 7.4.2.1 additional information no activity with betaine, gamma-aminobutyric acid, and taurine Aedes aegypti ? - ? 89 7.4.2.1 additional information the enzyme also generates significant inward currents for neutral aliphatic (Ile, Leu, Met), aromatic (Phe, Trp, Tyr) and even acidic amino acids Aedes aegypti ? - ? 89 7.4.2.1 additional information the enzyme catalyzes the transmembrane transport of single amino acid, multiple amino acids, auxin (indole-3-acetic acid) or gamma-aminobutyric acid Bemisia tabaci ? - ? 89 7.4.2.1 additional information the enzyme transports essential cationic and neutral amino acids with preference for L-arginine Aedes aegypti ? - ? 89 7.4.2.1 additional information LHT1 displays high affinity for neutral amino acids, L-His, and acidic amino acids. Amino acid permease 1 mediates uptake of several neutral amino acids as well as L-Glu and L-His but, similar to LHT1, activity for L-Arg and L-Lys is not detected Arabidopsis thaliana Col-0 ? - ? 89 7.4.2.1 additional information specifically transports branched-chain amino acids Lactococcus lactis MG1361 derivates ? - ? 89 7.4.2.1 additional information contributes to the alpha-aminoadipic acid flux Penicillium chrysogenum Wisconsin 54-1255 ? - ? 89 7.4.2.1 UTP + H2O + His/out dimeric HisP protein with a carboxy-terminal extension of 8 amino acids, 37% of the ATPase activity with ATP Salmonella enterica subsp. enterica serovar Typhimurium UDP + phosphate + His/in - ? 165504