5.1.1.7 (2S,6S)-2,6-diaminoheptanedioate - Haemophilus influenzae meso-diaminoheptanedioate - ? 368612 5.1.1.7 DL-3-fluoro-2,6-diaminopimelic acid rapid elimination, enamine product is formed which spontaneously cyclizes to tetrahydrodipicolinic acid Haemophilus influenzae tetrahydrodipicolinic acid + HF - ? 368613 5.1.1.7 LL-2,6-Diaminoheptanedioate - Bacteria meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Chlamydia trachomatis meso-Diaminoheptanedioate - r 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Haemophilus influenzae meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Bacillus subtilis meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Escherichia coli meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Escherichia coli meso-Diaminoheptanedioate - r 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Geobacillus stearothermophilus meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Zea mays meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Nicotiana tabacum meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Glycine max meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Priestia megaterium meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Corynebacterium glutamicum meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Mycobacterium tuberculosis meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Niallia circulans meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Brevibacillus laterosporus meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Paenibacillus macerans meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Virgibacillus pantothenticus meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Paenibacillus polymyxa meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - unclassified Bacteria meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Chlamydomonas sp. meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Acinetobacter baumannii meso-Diaminoheptanedioate - r 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Kitasatospora setae meso-Diaminoheptanedioate - r 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Corynebacterium glutamicum meso-Diaminoheptanedioate - r 880 5.1.1.7 LL-2,6-Diaminoheptanedioate r, between 25°C and 45°C at pH 7.0, the equilibrium mixture contains 65% meso-isomer and 35% LL-isomer Priestia megaterium meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Corynebacterium glutamicum ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025 meso-Diaminoheptanedioate - r 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Mycobacterium tuberculosis H37Rv meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Kitasatospora setae KM-6054 meso-Diaminoheptanedioate - r 880 5.1.1.7 LL-2,6-Diaminoheptanedioate - Priestia megaterium CII 19 meso-Diaminoheptanedioate - ? 880 5.1.1.7 LL-2,6-Diaminoheptanedioate enzyme active in two of three possible pathways for synthesis of L-Lys, acetyltransferase pathway and succinyltransferase pathway. Not active in D-diaminopimelate dehydrogenase variant Corynebacterium glutamicum ? - ? 369248 5.1.1.7 LL-2,6-Diaminoheptanedioate enzyme of Lys biosynthesis Priestia megaterium ? - ? 369248 5.1.1.7 LL-2,6-Diaminoheptanedioate enzyme of the diaminopimelic acid pathway for biosynthesis of Lys Zea mays ? - ? 369248 5.1.1.7 LL-2,6-Diaminoheptanedioate enzyme of Lys biosynthesis Priestia megaterium CII 19 ? - ? 369248 5.1.1.7 LL-2,6-diaminoheptanedioate stereo-conversion, the product complex (Enzyme/meso-diaminopimelate) is less stable than the reactant complex (Enzyme/LL-diaminopimelate) Haemophilus influenzae meso-diaminopimelate - r 407268 5.1.1.7 LL-2,6-diaminoheptanedioate stereo-inversion Escherichia coli meso-diaminopimelate - ? 407268 5.1.1.7 LL-2,6-diaminoheptanedioate stereo-inversion Mycobacterium tuberculosis meso-diaminopimelate the meso-isomer of diaminopimelic acid, a precursor of L-lysine, is a key component of the pentapeptide linker in bacterial peptidoglycan ? 407268 5.1.1.7 LL-2,6-diaminoheptanedioate stereo-inversion Mycobacterium tuberculosis H37Rv meso-diaminopimelate the meso-isomer of diaminopimelic acid, a precursor of L-lysine, is a key component of the pentapeptide linker in bacterial peptidoglycan ? 407268 5.1.1.7 LL-3-fluoro-2,6-diaminopimelic acid slow elimination of HF Haemophilus influenzae tetrahydrodipicolinic acid + HF - ? 368614 5.1.1.7 LL-oxa-diaminopimelic acid - Haemophilus influenzae meso-oxa-diaminopimelic acid - ? 389102 5.1.1.7 meso-diaminoheptanedioate - Mycobacterium tuberculosis LL-2,6-diaminoheptanedioate - r 401370 5.1.1.7 meso-diaminoheptanedioate - Mycobacterium tuberculosis H37Rv LL-2,6-diaminoheptanedioate - r 401370 5.1.1.7 additional information ligand binding to a cleft between the two domains of the enzyme is accompanied by domain closure with strictly conserved cysteine residues, Cys99 and Cys254, positioned to perform acid/base catalysis via a carbanion stabilization mechanism on the stereogenic alpha-carbon atom of the amino acid. Stereochemical control in catalysis is achieved by means of a highly symmetric catalytic site that can accommodate both the L and D stereogenic centers of DAP at the proximal site, whereas specific interactions at the distal site require only the L configuration Arabidopsis thaliana ? - ? 89 5.1.1.7 additional information no activity with DD-2,6-diaminoheptanedioate. Development of a simple method using thin-layer chromatography, in methanol/water (64:36) and with ninhydrin detection, and chiral column chromatography to allow preparation of pure diaminopimelate isomers and detect products, respectively, overview Kitasatospora setae ? - ? 89 5.1.1.7 additional information Chlamydia trachomatis dapF encodes a bifunctional enzyme capable of both D-glutamate racemase, EC 5.1.1.3, and diaminopimelate epimerase activities. DAP and glutamate appear to be competitive substrates, indicating that they share an active site despite the racemase reaction requiring the pyridoxal 5'-phosphate cofactor Chlamydia trachomatis ? - ? 89 5.1.1.7 additional information no activity with DD-2,6-diaminoheptanedioate. Development of a simple method using thin-layer chromatography, in methanol/water (64:36) and with ninhydrin detection, and chiral column chromatography to allow preparation of pure diaminopimelate isomers and detect products, respectively, overview Kitasatospora setae KM-6054 ? - ? 89