3.4.24.18 (7-methoxycoumarin-4-yl)acetyl-YVADAPK-(K-epsilon-DNP)-NH2 + H2O - Homo sapiens ? - ? 433013 3.4.24.18 2-aminobenzoic acid-RPPGFSPFRK(2,4-dinitrophenyl)G-OH + H2O - Rattus norvegicus ? - ? 367223 3.4.24.18 2-aminobenzoyl-Arg-Gly-Pro-Phe-Ser-Pro-(4-nitro)Phe-Arg + H2O fluorogenic bradykinin analog substrate, cleavage site: Phe-Ser Mus musculus 2-aminobenzoyl-Arg-Gly-Pro-Phe + Ser-Pro-(4-nitro)Phe-Arg - ? 16641 3.4.24.18 2-aminobenzoyl-Arg-Hyp-Gly-Phe-Ser-Pro-(4-nitro)Phe-Arg + H2O fluorogenic bradykinin analog substrate, cleavage site: Phe-Ser Mus musculus 2-aminobenzoyl-Arg-Hyp-Gly-Phe + Ser-Pro-(4-nitro)Phe-Arg - ? 16640 3.4.24.18 2-aminobenzoyl-Arg-Pro-Gly-Ala-Ser-Pro-(4-nitro)Phe-Arg + H2O fluorogenic bradykinin analog substrate, cleavage site: Ala-Ser Mus musculus 2-aminobenzoyl-Arg-Pro-Gly-Ala + Ser-Pro-(4-nitro)Phe-Arg - ? 16642 3.4.24.18 2-aminobenzoyl-Arg-Pro-Gly-Glu-Ser-Pro-(4-nitro)Phe-Arg + H2O fluorogenic bradykinin analog substrate, cleavage site: Glu-Ser Mus musculus 2-aminobenzoyl-Arg-Pro-Gly-Glu + Ser-Pro-(4-nitro)Phe-Arg - ? 16643 3.4.24.18 2-aminobenzoyl-Arg-Pro-Gly-Leu-Ser-Pro-(4-nitro)Phe-Arg + H2O fluorogenic bradykinin analog substrate, cleavage sites: Leu-Ser (major site) and Gly-Leu Mus musculus 2-aminobenzoyl-Arg-Pro-Gly-Leu + Ser-Pro-(4-nitro)Phe-Arg major products ? 16645 3.4.24.18 2-aminobenzoyl-Arg-Pro-Gly-Lys-Ser-Pro-(4-nitro)Phe-Arg + H2O fluorogenic bradykinin analog substrate, cleavage sites: Gly-Lys (major site) and Lys-Ser Mus musculus 2-aminobenzoyl-Arg-Pro-Gly + Lys-Ser-Pro-(4-nitro)Phe-Arg major products ? 16644 3.4.24.18 2-aminobenzoyl-Arg-Pro-Ile-Phe-Ser-Pro-(4-nitro)Phe-Arg + H2O fluorogenic bradykinin analog substrates, cleavage site: Phe-Ser Mus musculus 2-aminobenzoyl-Arg-Pro-Ile-Phe + Ser-Pro-(4-nitro)Phe-Arg - ? 16639 3.4.24.18 2-aminobenzoyl-RPPGFSPFRK-(dinitrophenyl)-G + H2O fluorogenic bradykinin analog substrate Mus musculus ? - ? 367224 3.4.24.18 actin + H2O murine homomeric recombinant enzyme Mus musculus ? - ? 363163 3.4.24.18 Aldolase + H2O - Mus musculus ? - ? 16618 3.4.24.18 alpha-melanocyte stimulating hormone + H2O i.e. acetyl-Ser-Tyr-Ser-Met-Gly-His-Phe-Arg-Trp-Gly-Lys-Pro-Val, cleavage sites: Ser-Met, Gly-Lys, mouse Mus musculus ? - ? 16611 3.4.24.18 alpha-melanocyte stimulating hormone + H2O peptide of the gastrointestinal tract Mus musculus ? - ? 16611 3.4.24.18 alpha-melanocyte-stimulating hormone + H2O - Mus musculus ? - ? 393933 3.4.24.18 alpha-melanocyte-stimulating hormone + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 393933 3.4.24.18 alpha-melanocyte-stimulating hormone + H2O murine homomeric recombinant enzyme Mus musculus ? - ? 393933 3.4.24.18 alpha-MSH + H2O - Mus musculus ? - ? 367455 3.4.24.18 alpha-MSH + H2O - Homo sapiens ? - ? 367455 3.4.24.18 angiotensin I + H2O - Mus musculus ? - ? 16449 3.4.24.18 angiotensin I + H2O peptide of the gastrointestinal tract Mus musculus ? - ? 16449 3.4.24.18 angiotensin I + H2O in human small intestine Homo sapiens ? - ? 16449 3.4.24.18 angiotensin I + H2O 2 cleavage sites: Tyr-Ile and Phe-His Homo sapiens Asp-Arg-Val-Tyr + Ile-His-Pro-Phe + Ile-His-Pro-Phe-His-Leu - ? 16604 3.4.24.18 angiotensin I + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu, cleavage site: Tyr-Ile Mus musculus Asp-Arg-Val-Tyr + Ile-His-Pro-Phe + Ile-His-Pro-Phe-His-Leu - ? 16604 3.4.24.18 angiotensin I + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu, cleavage site: Tyr-Ile Homo sapiens Asp-Arg-Val-Tyr + Ile-His-Pro-Phe + Ile-His-Pro-Phe-His-Leu - ? 16604 3.4.24.18 angiotensin I + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu, cleavage site: Tyr-Ile Rattus norvegicus Asp-Arg-Val-Tyr + Ile-His-Pro-Phe + Ile-His-Pro-Phe-His-Leu - ? 16604 3.4.24.18 angiotensin II + H2O - Homo sapiens ? - ? 16269 3.4.24.18 angiotensin II + H2O in human small intestine Homo sapiens ? - ? 16269 3.4.24.18 angiotensin II + H2O in mouse kidney Mus musculus ? - ? 16269 3.4.24.18 angiotensin II + H2O poor substrate Mus musculus Asp-Arg-Val-Tyr + Ile-His-Pro-Phe - ? 16605 3.4.24.18 angiotensin II + H2O poor substrate Rattus norvegicus Asp-Arg-Val-Tyr + Ile-His-Pro-Phe - ? 16605 3.4.24.18 angiotensin II + H2O cleavage site: Tyr-Ile Mus musculus Asp-Arg-Val-Tyr + Ile-His-Pro-Phe - ? 16605 3.4.24.18 angiotensin II + H2O cleavage site: Tyr-Ile Homo sapiens Asp-Arg-Val-Tyr + Ile-His-Pro-Phe - ? 16605 3.4.24.18 angiotensin II + H2O cleavage site: Tyr-Ile Rattus norvegicus Asp-Arg-Val-Tyr + Ile-His-Pro-Phe - ? 16605 3.4.24.18 angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Mus musculus Asp-Arg-Val-Tyr + Ile-His-Pro-Phe - ? 16605 3.4.24.18 angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Homo sapiens Asp-Arg-Val-Tyr + Ile-His-Pro-Phe - ? 16605 3.4.24.18 angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus Asp-Arg-Val-Tyr + Ile-His-Pro-Phe - ? 16605 3.4.24.18 angiotensin III + H2O poor substrate Rattus norvegicus Arg-Val-Tyr + Ile-His-Pro-Phe - ? 16606 3.4.24.18 angiotensin III + H2O i.e. Arg-Val-Tyr-Ile-His-Pro-Phe, cleavage site: Tyr-Ile Mus musculus Arg-Val-Tyr + Ile-His-Pro-Phe - ? 16606 3.4.24.18 angiotensin III + H2O i.e. Arg-Val-Tyr-Ile-His-Pro-Phe, cleavage site: Tyr-Ile Homo sapiens Arg-Val-Tyr + Ile-His-Pro-Phe - ? 16606 3.4.24.18 angiotensin III + H2O i.e. Arg-Val-Tyr-Ile-His-Pro-Phe, cleavage site: Tyr-Ile Rattus norvegicus Arg-Val-Tyr + Ile-His-Pro-Phe - ? 16606 3.4.24.18 annexin A1 + H2O substrate identified by 2D IEF/SDS-PAGE-based image analysis Canis lupus familiaris ? - ? 391291 3.4.24.18 Arg-Pro-Pro-Gly-(4-nitro)Phe-Ala-Pro-Phe-Arg + H2O chromogenic bradykinin analog Mus musculus Arg-Pro-Pro-Gly-(4-nitro)Phe + Ala-Pro-Phe-Arg - ? 16647 3.4.24.18 Arg-Pro-Pro-Gly-(4-nitro)Phe-Arg-Pro-Phe-Arg + H2O chromogenic bradykinin analog Mus musculus Arg-Pro-Pro-Gly-(4-nitro)Phe + Arg-Pro-Phe-Arg - ? 16648 3.4.24.18 Arg-Pro-Pro-Gly-(4-nitro)Phe-Lys-Pro-Phe-Arg + H2O chromogenic bradykinin analog Mus musculus Arg-Pro-Pro-Gly-(4-nitro)Phe + Lys-Pro-Phe-Arg - ? 16650 3.4.24.18 Arg-Pro-Pro-Gly-(4-nitro)Phe-Phe-Pro-Phe-Arg + H2O chromogenic bradykinin analog Mus musculus Arg-Pro-Pro-Gly-(4-nitro)Phe + Phe-Pro-Phe-Arg - ? 16649 3.4.24.18 Arg-Pro-Pro-Gly-(4-nitro)Phe-Ser-Pro-Phe-Arg + H2O i.e. nitrobradykinin, chromogenic bradykinin analog Mus musculus Arg-Pro-Pro-Gly-(4-nitro)Phe + Ser-Pro-Phe-Arg - ? 16646 3.4.24.18 azocasein + H2O - Mus musculus ? - ? 15347 3.4.24.18 azocasein + H2O - Homo sapiens ? - ? 15347 3.4.24.18 azocasein + H2O - Rattus norvegicus ? - ? 15347 3.4.24.18 azocasein + H2O - Mus musculus C57BL/6N ? - ? 15347 3.4.24.18 azocasein + H2O - Mus musculus fragments of azocasein - ? 15660 3.4.24.18 azocasein + H2O - Homo sapiens fragments of azocasein - ? 15660 3.4.24.18 azocasein + H2O excellent substrate for mouse, poorer substrate for rat and human enzymes Mus musculus fragments of azocasein - ? 15660 3.4.24.18 azocasein + H2O excellent substrate for mouse, poorer substrate for rat and human enzymes Homo sapiens fragments of azocasein - ? 15660 3.4.24.18 azocasein + H2O excellent substrate for mouse, poorer substrate for rat and human enzymes Rattus norvegicus fragments of azocasein - ? 15660 3.4.24.18 azocasein + H2O better substrate for mouse enzyme than for rat enzyme Mus musculus fragments of azocasein - ? 15660 3.4.24.18 azocasein + H2O better substrate for mouse enzyme than for rat enzyme Rattus norvegicus fragments of azocasein - ? 15660 3.4.24.18 azocasein + H2O - Mus musculus male ICR fragments of azocasein - ? 15660 3.4.24.18 azocasein + H2O - Homo sapiens PPH fragments of azocasein - ? 15660 3.4.24.18 azocasein + H2O excellent substrate for mouse, poorer substrate for rat and human enzymes Homo sapiens PPH fragments of azocasein - ? 15660 3.4.24.18 Azocoll + H2O poor substrate Mus musculus ? - ? 15352 3.4.24.18 B-type natriuretic peptide + H2O - Homo sapiens ? - ? 417896 3.4.24.18 B-type natriuretic peptide + H2O meprin A degrades rat BNP but not human BNP Homo sapiens ? - ? 417896 3.4.24.18 B-type natriuretic peptide 1-32 + H2O - Homo sapiens B-type natriuretic peptide 8-32 + Ser-Pro-Lys-Met-Val-Gln-Gly - ? 414333 3.4.24.18 benzoyl-Gly-His-Leu + H2O very poor substrate, t1/2 of more than 16 h Homo sapiens ? - ? 14882 3.4.24.18 benzoyl-Gly-His-Leu + H2O very poor substrate, t1/2 of more than 16 h Homo sapiens PPH ? - ? 14882 3.4.24.18 benzoyl-L-tyrosyl-4-aminobenzoic acid + H2O - Mus musculus ? - ? 433497 3.4.24.18 benzoyl-L-tyrosyl-4-aminobenzoic acid + H2O - Homo sapiens ? - ? 433497 3.4.24.18 benzoyl-L-tyrosyl-4-aminobenzoic acid + H2O - Rattus norvegicus ? - ? 433497 3.4.24.18 Benzyloxycarbonyl-Arg-Arg 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 8.2% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ? - ? 16150 3.4.24.18 Benzyloxycarbonyl-Arg-Arg 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 8.2% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens PPH ? - ? 16150 3.4.24.18 Benzyloxycarbonyl-Glu-Lys-Lys 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 9.1% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ? - ? 16638 3.4.24.18 Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide + H2O - Mus musculus ? - ? 16044 3.4.24.18 Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 3.6% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ? - ? 16044 3.4.24.18 Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 3.6% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens PPH ? - ? 16044 3.4.24.18 Benzyloxycarbonyl-Val-Leu-Lys 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 10.4% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ? - ? 16637 3.4.24.18 Big endothelin I + H2O rat Rattus norvegicus ? - ? 16610 3.4.24.18 bombesin + H2O - Mus musculus ? - ? 366787 3.4.24.18 bombesin + H2O peptide of the gastrointestinal tract Mus musculus ? - ? 366787 3.4.24.18 bradykinin + H2O - Mus musculus Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg - ? 16602 3.4.24.18 bradykinin + H2O - Homo sapiens Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg - ? 16602 3.4.24.18 bradykinin + H2O - Rattus norvegicus Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg - ? 16602 3.4.24.18 bradykinin + H2O i.e. Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, bradykinin(1-7) and bradykinin(1-8) best substrates next to substance P Homo sapiens Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg - ? 16602 3.4.24.18 bradykinin + H2O one cleavage site: Phe-Ser (major cleavage site) Rattus norvegicus Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg - ? 16602 3.4.24.18 bradykinin + H2O one cleavage site: Phe-Ser Mus musculus Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg - ? 16602 3.4.24.18 bradykinin + H2O one cleavage site: Phe-Ser Homo sapiens Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg - ? 16602 3.4.24.18 bradykinin + H2O one cleavage site: Phe-Ser Rattus norvegicus Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg - ? 16602 3.4.24.18 bradykinin + H2O minor cleavage site: Gly-Phe Rattus norvegicus Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg - ? 16602 3.4.24.18 bradykinin + H2O - Mus musculus ? - ? 16889 3.4.24.18 bradykinin + H2O - Homo sapiens ? - ? 16889 3.4.24.18 bradykinin + H2O - Rattus norvegicus ? - ? 16889 3.4.24.18 bradykinin + H2O peptide of the gastrointestinal tract Mus musculus ? - ? 16889 3.4.24.18 bradykinin + H2O in human small intestine Homo sapiens ? - ? 16889 3.4.24.18 bradykinin + H2O in mouse kidney Mus musculus ? - ? 16889 3.4.24.18 bradykinin + H2O in rat kidney Rattus norvegicus ? - ? 16889 3.4.24.18 bradykinin + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 16889 3.4.24.18 bradykinin + H2O murine homomeric recombinant enzyme Mus musculus ? - ? 16889 3.4.24.18 casein + H2O - Mus musculus ? - ? 15445 3.4.24.18 catalytic subunit of protein kinase A + H2O in rat kidney Rattus norvegicus ? - ? 432727 3.4.24.18 CCK8 nonsulfated + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 433548 3.4.24.18 CCK8 nonsulfated + H2O murine homomeric recombinant enzyme Mus musculus ? - ? 433548 3.4.24.18 CCK8NH2 + H2O - Mus musculus L-Asp-L-Tyr-L-Met-Gly-L-Trp-L-Met + L-Asp-L-Phe - ? 367445 3.4.24.18 cerulein + H2O - Mus musculus ? - ? 367218 3.4.24.18 cerulein + H2O peptide of the gastrointestinal tract Mus musculus ? - ? 367218 3.4.24.18 cholecystokinin 8-sulfate + H2O - Mus musculus ? - ? 367225 3.4.24.18 collagen I + H2O - Mus musculus ? - ? 36832 3.4.24.18 Collagen IV + H2O - Mus musculus ? - ? 17094 3.4.24.18 Collagen IV + H2O - Homo sapiens ? - ? 17094 3.4.24.18 Collagen IV + H2O in rat kidney Rattus norvegicus ? - ? 17094 3.4.24.18 Collagen type IV + H2O - Rattus norvegicus Hydrolyzed collagen type IV - ? 15658 3.4.24.18 collagen type IV + H2O meprin alpha can degrade collagen type IV Homo sapiens ? - ? 65137 3.4.24.18 collagen type IV + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 65137 3.4.24.18 collagen type V + H2O substrate identified by 2D IEF/SDS-PAGE-based image analysis Canis lupus familiaris ? - ? 384460 3.4.24.18 E-cadherin + H2O an extracellular matrix-related substrate Mus musculus ? - ? 367535 3.4.24.18 E-cadherin + H2O an extracellular matrix-related substrate Homo sapiens ? - ? 367535 3.4.24.18 Endothelin I + H2O rat Rattus norvegicus ? - ? 16609 3.4.24.18 fibrillar procollagen type I + H2O the enzyme is capable of cleaving off the globular C- and N-terminal prodomains of fibrillar collagen type I and type III. Cleavage sites are at positions YYRA1218-/-1219DDAN and VRDR1227/-1228DLEV for the alpha1(I) chain, and additionally GGGY1108-/-1109DFGY for alpha2(I). For the N-terminal propeptide SYGY166-/-167DEKS (alpha1(I)) and AAQY81-/-82DGKG (alpha2(I)) are identified as meprin cleavage sites Mus musculus fibrillar collagen type I + fibrillar collagen type I propeptide - ? 432800 3.4.24.18 fibrillar procollagen type I + H2O the enzyme is capable of cleaving off the globular C- and N-terminal prodomains of fibrillar collagen type I and type III. Cleavage sites are at positions YYRA1218-/-1219DDAN and VRDR1227/-1228DLEV for the alpha1(I) chain, and additionally GGGY1108-/-1109DFGY for alpha2(I). For the N-terminal propeptide SYGY166-/-167DEKS (alpha1(I)) and AAQY81-/-82DGKG (alpha2(I)) are identified as meprin cleavage sites Homo sapiens fibrillar collagen type I + fibrillar collagen type I propeptide - ? 432800 3.4.24.18 fibrillar procollagen type III + H2O the enzyme is capable of cleaving off the globular C- and N-terminal prodomains of fibrillar collagen type I and type III Mus musculus fibrillar collagen type III + fibrillar collagen type I propeptide - ? 432801 3.4.24.18 fibrillar procollagen type III + H2O the enzyme is capable of cleaving off the globular C- and N-terminal prodomains of fibrillar collagen type I and type III Homo sapiens fibrillar collagen type III + fibrillar collagen type I propeptide - ? 432801 3.4.24.18 Fibronectin + H2O - Mus musculus ? - ? 15394 3.4.24.18 Fibronectin + H2O - Homo sapiens ? - ? 15394 3.4.24.18 Fibronectin + H2O cleavage at positions Y294-Q295, N709-T210 and in the linker regions between fibronectin type I repeats 5 and 6 and fibronectin type II repeats 1 and 2 Homo sapiens ? - ? 15394 3.4.24.18 Fibronectin + H2O an extracellular matrix-related substrate Mus musculus ? - ? 15394 3.4.24.18 Fibronectin + H2O an extracellular matrix-related substrate Homo sapiens ? - ? 15394 3.4.24.18 Fibronectin + H2O in rat kidney Rattus norvegicus ? - ? 15394 3.4.24.18 Fibronectin + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 15394 3.4.24.18 Fibronectin + H2O - Rattus norvegicus Hydrolyzed fibronectin - ? 15655 3.4.24.18 gastri-releasing peptide-(14-27) + H2O peptide of the gastrointestinal tract Mus musculus ? - ? 367215 3.4.24.18 gastrin + H2O - Homo sapiens ? - ? 65359 3.4.24.18 gastrin 17 + H2O mutant Y199K Mus musculus ? - ? 367226 3.4.24.18 gastrin-releasing peptide + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 392027 3.4.24.18 gastrin-releasing peptide + H2O murine homomeric recombinant enzyme Mus musculus ? - ? 392027 3.4.24.18 gastrin-releasing peptide-(14-27) + H2O - Mus musculus ? - ? 432808 3.4.24.18 Gelatin + H2O - Rattus norvegicus Hydrolyzed gelatin - ? 15486 3.4.24.18 Gelatin + H2O - Mus musculus ? - ? 16570 3.4.24.18 Gelatin + H2O in rat kidney Rattus norvegicus ? - ? 16570 3.4.24.18 ghrelin + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 384770 3.4.24.18 ghrelin + H2O murine homomeric recombinant enzyme Mus musculus ? - ? 384770 3.4.24.18 Glucagon + H2O - Mus musculus ? - ? 15578 3.4.24.18 Glucagon + H2O peptide of the gastrointestinal tract Mus musculus ? - ? 15578 3.4.24.18 Glucagon + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 15578 3.4.24.18 Glucagon + H2O murine homomeric recombinant enzyme Mus musculus ? - ? 15578 3.4.24.18 Glutaryl-Phe 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 2.4% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ? - ? 16634 3.4.24.18 Gonadotropin + H2O mouse Mus musculus ? - ? 16613 3.4.24.18 GRP + H2O - Homo sapiens ? - ? 453229 3.4.24.18 Hemoglobin + H2O poor substrate Mus musculus ? - ? 15450 3.4.24.18 Human alpha-atrial natiuretic peptide + H2O - Rattus norvegicus ? - ? 16616 3.4.24.18 Human alpha-atrial natiuretic peptide + H2O rat Rattus norvegicus ? - ? 16616 3.4.24.18 Human transforming growth factor + H2O rat Rattus norvegicus ? - ? 16608 3.4.24.18 insulin + H2O in mouse kidney Mus musculus ? - ? 36836 3.4.24.18 insulin B chain + H2O in human small intestine Homo sapiens ? - ? 37184 3.4.24.18 Insulin B-chain + H2O - Mus musculus Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O I125-iodinated Rattus norvegicus Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O prevalent cleavage sites are Gly20-Glu21, Phe24-Phe25 and Phe25-Tyr26 Mus musculus Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O prevalent cleavage sites are Gly20-Glu21, Phe24-Phe25 and Phe25-Tyr26 Homo sapiens Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O prevalent cleavage sites are Gly20-Glu21, Phe24-Phe25 and Phe25-Tyr26 Rattus norvegicus Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O prevalent cleavage sites are Gly20-Glu21, Phe24-Phe25 and Phe25-Tyr26 Mus musculus Hydrolyzed insulin B-chain 15 different peptide fragments ? 15577 3.4.24.18 Insulin B-chain + H2O the others are Leu6-Cys(SO3-)7, Ala14-Leu15, Gly8-Ser9, His10-Leu11, Leu15-Tyr16, His5-Leu6 and Leu17-Val18 Mus musculus Hydrolyzed insulin B-chain 13 different peptide fragments ? 15577 3.4.24.18 Insulin B-chain + H2O 10 cleavage sites Mus musculus Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O 10 cleavage sites Homo sapiens Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O 10 cleavage sites Rattus norvegicus Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O 10 cleavage sites Mus musculus Hydrolyzed insulin B-chain 15 different peptide fragments ? 15577 3.4.24.18 Insulin B-chain + H2O 7 major and 3 minor sites Mus musculus Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O 7 major and 3 minor sites Homo sapiens Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O 7 major and 3 minor sites Rattus norvegicus Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O oxidized form Mus musculus Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O oxidized form Homo sapiens Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O oxidized form Rattus norvegicus Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O oxidized form Mus musculus Hydrolyzed insulin B-chain 15 different peptide fragments ? 15577 3.4.24.18 Insulin B-chain + H2O oxidized form Mus musculus Hydrolyzed insulin B-chain 13 different peptide fragments ? 15577 3.4.24.18 Insulin B-chain + H2O prevalent cleavage sites are Gly20-Glu21, Phe24-Phe25 and Phe25-Tyr26 Mus musculus male ICR Hydrolyzed insulin B-chain 15 different peptide fragments ? 15577 3.4.24.18 Insulin B-chain + H2O 10 cleavage sites Mus musculus male ICR Hydrolyzed insulin B-chain 15 different peptide fragments ? 15577 3.4.24.18 Insulin B-chain + H2O oxidized form Mus musculus male ICR Hydrolyzed insulin B-chain 15 different peptide fragments ? 15577 3.4.24.18 Insulin B-chain + H2O prevalent cleavage sites are Gly20-Glu21, Phe24-Phe25 and Phe25-Tyr26 Homo sapiens PPH Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O 10 cleavage sites Homo sapiens PPH Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O 7 major and 3 minor sites Homo sapiens PPH Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 Insulin B-chain + H2O oxidized form Homo sapiens PPH Hydrolyzed insulin B-chain - ? 15577 3.4.24.18 interleukin-1beta + H2O meprin beta activates interleukin 18 Homo sapiens ? - ? 362384 3.4.24.18 interleukin-6 + H2O recombinant human substrate expressed in an eukaryotic cell line, inactivation Mus musculus ? - ? 384924 3.4.24.18 interleukin-6 + H2O recombinant human substrate expressed in eukaryotic B9 cell line, inactivation. Human meprin A cleaves 20% of human interleukin-6 of about 22 kDa to a smaller product of about 21 kDa within 2 h. Meprin A cleaves human interleukin-6 at its C-terminus, fragmentation pattern, overview Homo sapiens ? - ? 384924 3.4.24.18 interleukin-6 + H2O recombinant murine substrate expressed in Escherichia coli, inactivation. The enzyme cleaves 90% of the substrate within 2 h, approximately 50 and 15% of the mIL-6 signal remain after 0.5 and 1 h of incubation with mouse meprin A, fragmentation pattern, overview Mus musculus ? - ? 384924 3.4.24.18 interleukin-6 + H2O recombinant human substrate expressed in an eukaryotic cell line, inactivation Mus musculus C57BL6 ? - ? 384924 3.4.24.18 interleukin-6 + H2O recombinant murine substrate expressed in Escherichia coli, inactivation. The enzyme cleaves 90% of the substrate within 2 h, approximately 50 and 15% of the mIL-6 signal remain after 0.5 and 1 h of incubation with mouse meprin A, fragmentation pattern, overview Mus musculus C57BL6 ? - ? 384924 3.4.24.18 KKGYVADAP-4-nitroanilide + H2O - Homo sapiens KKGYVA + DAP-4-nitroanilide - ? 450108 3.4.24.18 L-Leu 2-naphthylamide + H2O - Mus musculus ? - ? 16598 3.4.24.18 laminin + H2O - Rattus norvegicus fragments of laminin - ? 15656 3.4.24.18 Laminin + H2O - Mus musculus ? - ? 16571 3.4.24.18 Laminin + H2O in rat kidney Rattus norvegicus ? - ? 16571 3.4.24.18 laminin 1 + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 433895 3.4.24.18 laminin 5 + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 433896 3.4.24.18 laminin V + H2O - Homo sapiens ? - ? 448735 3.4.24.18 Leu-Val-Tyr 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 6.2% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ? - ? 16632 3.4.24.18 Luliberin + H2O i.e. luteinizing-hormone releasing hormone, preferred cleavage site: Trp3-Ser4, other sites are Ser4-Tyr5 and Tyr5-Gly6 Rattus norvegicus ? - ? 16614 3.4.24.18 luteinizing hormone releasing hormone LHRH + H2O - Mus musculus ? - ? 367219 3.4.24.18 luteinizing hormone releasing hormone LHRH + H2O - Homo sapiens ? - ? 367219 3.4.24.18 luteinizing hormone releasing hormone LHRH + H2O peptide of the gastrointestinal tract Mus musculus ? - ? 367219 3.4.24.18 luteinizing-hormone-releasing hormone + H2O - Mus musculus ? - ? 74107 3.4.24.18 luteinizing-hormone-releasing hormone + H2O in human small intestine Homo sapiens ? - ? 74107 3.4.24.18 luteinizing-hormone-releasing hormone + H2O in rat kidney Rattus norvegicus ? - ? 74107 3.4.24.18 luteinizing-hormone-releasing hormone + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 74107 3.4.24.18 luteinizing-hormone-releasing hormone + H2O murine homomeric recombinant enzyme Mus musculus ? - ? 74107 3.4.24.18 lysyl oxidase + H2O substrate identified by 2D IEF/SDS-PAGE-based image analysis Canis lupus familiaris ? - ? 405749 3.4.24.18 miniprocollagen alpha1(I) homotrimers + H2O - Mus musculus ? - ? 433932 3.4.24.18 MMP1 protein + H2O an extracellular matrix-related substrate Mus musculus ? - ? 432847 3.4.24.18 MMP1 protein + H2O an extracellular matrix-related substrate Homo sapiens ? - ? 432847 3.4.24.18 additional information hydrolysis occurs on carboxy side of aromatic residues Homo sapiens ? - ? 89 3.4.24.18 additional information hydrolysis occurs on carboxy side of aromatic residues Rattus norvegicus ? - ? 89 3.4.24.18 additional information poor substrates are compounds with 3 or less amino acids Homo sapiens ? - ? 89 3.4.24.18 additional information little or no activity towards benzoylarginine 2-naphthylamide, benzoylglycylarginine, benzyloxycarbonyl-Glu-Tyr, acetyl-Phe 2-naphthylester Mus musculus ? - ? 89 3.4.24.18 additional information no hydrolysis of Leu 4-nitroanilide, benzoyl-Arg-4-nitroanilide, succinyl-Ala 4-nitroanilide, Arg 4-methylcoumarinin 7-amide, benzoyl-Phe-Val-Arg 4-methylcoumarin 7-amide, Gly-Gly-Phe-Leu, Tyr-Gly-Gly-Phe-Leu, Tyr-Gly-Gly-Phe-Met, Leu-Arg-Arg-Ala-Ser-Leu-Gly, Ala-Phe-Pro-Leu-Gly-Phe, benzoyl-Phe-Val-Arg Mus musculus ? - ? 89 3.4.24.18 additional information dansyl-(D)-Ala-Gly-4-phenylalanylglycine, [Leu]-enkephalin, [Met]-enkephalin Homo sapiens ? - ? 89 3.4.24.18 additional information insulin, [Arg8]-vasopressin, cytochrome c, ovalbumin, serum albumin Rattus norvegicus ? - ? 89 3.4.24.18 additional information hydrolyzes peptides of at least 8 amino acids and prefers peptide bonds flanked by hydrophobic or neutral amino acid residues although hydrolysis is not limited to these bonds Mus musculus ? - ? 89 3.4.24.18 additional information orcokinin and gastrin 17 are no substrates Mus musculus ? - ? 89 3.4.24.18 additional information orcokinin, gastrin 17, peptide YY, kinetensin, [Lys8]-vasopressin, somatostatin, kassinin, oxytocin, and alpha-neurokinin are no substrates Mus musculus ? - ? 89 3.4.24.18 additional information cleaves growth factors, extracellular matrix proteins, and biological active peptides Mus musculus ? - ? 89 3.4.24.18 additional information no substrate: intact collagen I Homo sapiens ? - ? 89 3.4.24.18 additional information 2D IEF/SDS-PAGE-based image analysis procedure to analyse candidate substrates for meprin in a cell culture system-based approach and identification of meprin substrates with cleaved non-trypsin-generated N- and C-termini in peptide fragments upon LC-MS/MS analysis Canis lupus familiaris ? - ? 89 3.4.24.18 additional information meprin interacts with epithelial Na+ channel (ENaC) Homo sapiens ? - ? 89 3.4.24.18 additional information no activity with claudin-4 in MDCK cells Mus musculus ? - ? 89 3.4.24.18 additional information no activity with claudin-4 in MDCK cells Canis lupus familiaris ? - ? 89 3.4.24.18 additional information the enzyme is capable of hydrolyzing and processing a large number of substrates, including extracellular matrix proteins, cytokines, adherens junction proteins, hormones, bioactive peptides, and cell surface proteins Mus musculus ? - ? 89 3.4.24.18 additional information the enzyme is capable of hydrolyzing and processing a large number of substrates, including extracellular matrix proteins, cytokines, adherens junction proteins, hormones, bioactive peptides, and cell surface proteins Homo sapiens ? - ? 89 3.4.24.18 additional information the enzyme is capable of hydrolyzing and processing a large number of substrates, including extracellular matrix proteins, cytokines, adherens junction proteins, hormones, bioactive peptides, and cell surface proteins Rattus norvegicus ? - ? 89 3.4.24.18 additional information enzyme cleavage specificity, overview Homo sapiens ? - ? 89 3.4.24.18 additional information meprin beta preferentially cleaves substrates with acidic amino acids in P1'-position Homo sapiens ? - ? 89 3.4.24.18 additional information meprin alpha, but not meprin beta, cleaves Reelin in which Asp2689 is replaced with Lys (Reelin-DK mutant) Mus musculus ? - ? 89 3.4.24.18 additional information the cleavage of a meprin alpha substrate leads to generation of the prolyl tripeptidyl aminopeptidase (PtP, EC 3.4.14.12) substrate, and the activity of PtP results in release of a chromophore or fluorophore, coupled assay method evaluation, overview Homo sapiens ? - ? 89 3.4.24.18 additional information no activity with claudin-4 in MDCK cells Mus musculus C57BL/6 ? - ? 89 3.4.24.18 additional information the enzyme is capable of hydrolyzing and processing a large number of substrates, including extracellular matrix proteins, cytokines, adherens junction proteins, hormones, bioactive peptides, and cell surface proteins Mus musculus C57BL/6N ? - ? 89 3.4.24.18 additional information no activity with claudin-4 in MDCK cells Canis lupus familiaris Madin-Darby ? - ? 89 3.4.24.18 additional information hydrolysis occurs on carboxy side of aromatic residues Homo sapiens PPH ? - ? 89 3.4.24.18 additional information dansyl-(D)-Ala-Gly-4-phenylalanylglycine, [Leu]-enkephalin, [Met]-enkephalin Homo sapiens PPH ? - ? 89 3.4.24.18 additional information poor substrates are compounds with 3 or less amino acids Homo sapiens PPH ? - ? 89 3.4.24.18 Muc2 protein + H2O an extracellular matrix-related substrate Mus musculus ? - ? 432854 3.4.24.18 Muc2 protein + H2O an extracellular matrix-related substrate Homo sapiens ? - ? 432854 3.4.24.18 N-Benzoyl-L-tyrosyl-4-aminobenzoate + H2O - Rattus norvegicus N-Benzoyl-L-tyrosine + 4-aminobenzoate - ? 16596 3.4.24.18 N-Benzoyl-L-tyrosyl-4-aminobenzoate + H2O i.e. PABA-peptide, rat, human, arylamidolysis Homo sapiens N-Benzoyl-L-tyrosine + 4-aminobenzoate - ? 16596 3.4.24.18 N-Benzoyl-L-tyrosyl-4-aminobenzoate + H2O i.e. PABA-peptide, rat, human, arylamidolysis Rattus norvegicus N-Benzoyl-L-tyrosine + 4-aminobenzoate - ? 16596 3.4.24.18 N-Benzoyl-L-tyrosyl-4-aminobenzoate + H2O very poor substrate, t1/2 of more than 16 h Homo sapiens N-Benzoyl-L-tyrosine + 4-aminobenzoate - ? 16596 3.4.24.18 N-Benzoyl-L-tyrosyl-4-aminobenzoate + H2O very poor substrate, t1/2 of more than 16 h Homo sapiens PPH N-Benzoyl-L-tyrosine + 4-aminobenzoate - ? 16596 3.4.24.18 neuropeptide Y + H2O - Mus musculus ? - ? 367217 3.4.24.18 neuropeptide Y + H2O peptide of the gastrointestinal tract Mus musculus ? - ? 367217 3.4.24.18 neurotensin + H2O - Mus musculus ? - ? 15385 3.4.24.18 neurotensin + H2O i.e. pyro-Glu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu, mouse, rat, cleavage sites: Glu-Asn, Asn-Lys Mus musculus ? - ? 15385 3.4.24.18 neurotensin + H2O i.e. pyro-Glu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu, mouse, rat, cleavage sites: Glu-Asn, Asn-Lys Rattus norvegicus ? - ? 15385 3.4.24.18 neurotensin + H2O peptide of the gastrointestinal tract Mus musculus ? - ? 15385 3.4.24.18 neurotensin + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 15385 3.4.24.18 neurotensin + H2O murine homomeric recombinant enzyme Mus musculus ? - ? 15385 3.4.24.18 neurotensin + H2O - Mus musculus C57BL/6N ? - ? 15385 3.4.24.18 neurotensin + H2O murine homomeric recombinant enzyme Mus musculus C57BL/6N ? - ? 15385 3.4.24.18 Nidogen + H2O in rat kidney Rattus norvegicus ? - ? 17043 3.4.24.18 nidogen 1 + H2O - Homo sapiens ? - ? 432875 3.4.24.18 nidogen 1 + H2O an extracellular matrix-related substrate Mus musculus ? - ? 432875 3.4.24.18 nidogen 1 + H2O an extracellular matrix-related substrate Homo sapiens ? - ? 432875 3.4.24.18 nidogen-1 + H2O cleavage at D67-R68 and Q363-H364 Homo sapiens ? - ? 385410 3.4.24.18 nidogen-1 + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 385410 3.4.24.18 occludin + H2O in MDCK cells Mus musculus ? - ? 393042 3.4.24.18 occludin + H2O in MDCK cells and in micelles Canis lupus familiaris ? - ? 393042 3.4.24.18 occludin + H2O recombinant MBP-conjugated human substrate and recombinant enzyme, cleavage products of extracellular loop 1 and loop 2 are determined by mass spectrometry, overview. The cleavage site is between Gly100 and Ser101 is on the first extracellular loop of occludin Canis lupus familiaris ? - ? 393042 3.4.24.18 occludin + H2O recombinant substrate in micelles and recombinant enzyme, cleavage products of extracellular loop 1 and loop 2 are determined by mass spectrometry, overview. The cleavage site is between Gly100 and Ser101 is on the first extracellular loop of occludin Mus musculus ? - ? 393042 3.4.24.18 occludin + H2O in MDCK cells Mus musculus C57BL/6 ? - ? 393042 3.4.24.18 occludin + H2O recombinant substrate in micelles and recombinant enzyme, cleavage products of extracellular loop 1 and loop 2 are determined by mass spectrometry, overview. The cleavage site is between Gly100 and Ser101 is on the first extracellular loop of occludin Mus musculus C57BL/6 ? - ? 393042 3.4.24.18 occludin + H2O in MDCK cells and in micelles Canis lupus familiaris Madin-Darby ? - ? 393042 3.4.24.18 occludin + H2O recombinant MBP-conjugated human substrate and recombinant enzyme, cleavage products of extracellular loop 1 and loop 2 are determined by mass spectrometry, overview. The cleavage site is between Gly100 and Ser101 is on the first extracellular loop of occludin Canis lupus familiaris Madin-Darby ? - ? 393042 3.4.24.18 orcokinin + H2O - Homo sapiens ? - ? 367452 3.4.24.18 Oxytocin + H2O poor substrate Homo sapiens Hydrolyzed oxytocin - ? 16617 3.4.24.18 oxytocin + H2O in human small intestine Homo sapiens ? - ? 65396 3.4.24.18 Parathyroid hormone + H2O involved in PTH-degradation in human kidney Homo sapiens ? - ? 15314 3.4.24.18 Parathyroid hormone + H2O in rat kidney Rattus norvegicus ? - ? 15314 3.4.24.18 Parathyroid hormone + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 15314 3.4.24.18 Parathyroid hormone + H2O murine homomeric recombinant enzyme Mus musculus ? - ? 15314 3.4.24.18 Parathyroid hormone + H2O murine homomeric recombinant enzyme Mus musculus C57BL/6N ? - ? 15314 3.4.24.18 Parathyroid hormone + H2O involved in PTH-degradation in human kidney Homo sapiens PPH ? - ? 15314 3.4.24.18 Parathyroid hormone + H2O i.e. hPTH-(1-84), in vivo and in vitro Homo sapiens Hydrolyzed parathyroid hormone - ? 16621 3.4.24.18 parathyroid hormone fragment 13-34 + H2O - Mus musculus ? - ? 367222 3.4.24.18 parathyroid hormone fragment 13-34 + H2O peptide of the gastrointestinal tract Mus musculus ? - ? 367222 3.4.24.18 pro-interleukin 1beta + H2O cleavage at the H115-D116 bond, which is one amino acid N-terminal to the caspase-1 cleavage site and five amino acids C-terminal to the meprin beta site. Both oligomeric meprin A and recombinant meprin alpha are capable of cleaving Rattus norvegicus interleukin 1beta + H2O the biological activity of the pro-interleukin-1beta cleaved product produced by meprin A, is 3fold higher to that of the interleukin-1beta product produced by meprin b or caspase-1 ? 406448 3.4.24.18 Pro-interleukin-1beta + H2O - Rattus norvegicus ? - ? 432907 3.4.24.18 pro-KLK7 + H2O meprin beta cleaves pro-KLK7 between Gly17 and Asp18 Homo sapiens KLK7 + ? - ? 415148 3.4.24.18 procollagen I + H2O meprin alpha removes both the C- and N-propeptides of type I procollagen, subsequently releasing fibril-forming mature collagen molecules. The C-terminal cleavage sites in the proalpha1(I) chain generated by the enzyme is identified as Ala1218/Asp1219, identical to the BMP-1 cleavage site, and also Arg1227/Asp1228, nine residues C-terminal to the BMP-1 cleavage site Mus musculus collagen I + propeptide of collagen III - ? 432911 3.4.24.18 procollagen I + H2O recombinant human substrate, generation of mature collagen molecules that spontaneously assemble into collagen fibrils Mus musculus collagen I + propeptide of collagen III - ? 432911 3.4.24.18 procollagen III + H2O meprin alpha can process procollagen III Homo sapiens ? - ? 413544 3.4.24.18 procollagen type III + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 385608 3.4.24.18 protein GRP + H2O - Mus musculus ? - ? 398201 3.4.24.18 protein GRP + H2O - Homo sapiens ? - ? 398201 3.4.24.18 protein kinase A + H2O the enzyme cleaves at defined sites, isoform-specific interactions between the catalytic subunit of PKA (PKA C) and meprins, overview Mus musculus ? - ? 432914 3.4.24.18 protein kinase A catalytic subunit Cbeta1 + H2O the enzyme cleaves at defined sites, cytosolic-enriched kidney proteins from meprin alphabeta double knockout mice, and purified forms of recombinant mouse PKA Calpha, Cbeta1, and Cbeta2, are incubated with activated forms of either homomeric meprinA or meprin B, EC 3.4.24.63, product analysis by mass spectrometry, overview. Meprin A only cleaves PKA Cbeta1 Mus musculus ? - ? 434162 3.4.24.18 protein LHRH + H2O - Mus musculus ? - ? 398204 3.4.24.18 protein LHRH + H2O - Homo sapiens ? - ? 398204 3.4.24.18 protein PTH12-34 + H2O - Mus musculus ? - ? 398205 3.4.24.18 protein PTH12-34 + H2O - Homo sapiens ? - ? 398205 3.4.24.18 Reelin + H2O Reelin is a secreted glycoprotein whose function is regulated by proteolysis Mus musculus ? - ? 448888 3.4.24.18 Reelin + H2O cleavage between Ala2688 and Asp2689, the specific cleavage site of Reelin called C-t is located approximately between the sixth and seventh Reelin repeat Mus musculus ? - ? 448888 3.4.24.18 sCCK8NH2 + H2O peptide of the gastrointestinal tract Mus musculus L-Asp-L-Tyr(SO3)-L-Met-Gly-L-Trp-L-Met + L-Asp-L-Phe - ? 367216 3.4.24.18 Secretin + H2O - Mus musculus ? - ? 17174 3.4.24.18 Secretin + H2O - Homo sapiens ? - ? 17174 3.4.24.18 Secretin + H2O peptide of the gastrointestinal tract Mus musculus ? - ? 17174 3.4.24.18 Secretin + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 17174 3.4.24.18 Secretin + H2O murine homomeric recombinant enzyme Mus musculus ? - ? 17174 3.4.24.18 Substance P + H2O - Homo sapiens Hydrolyzed substance P - ? 16615 3.4.24.18 Substance P + H2O best substrate Homo sapiens Hydrolyzed substance P - ? 16615 3.4.24.18 Substance P + H2O rat Rattus norvegicus Hydrolyzed substance P - ? 16615 3.4.24.18 Substance P + H2O cleavage sites: Glu6-Phe7, Phe7-Phe8, Phe8-Gly9 Rattus norvegicus Hydrolyzed substance P - ? 16615 3.4.24.18 Substance P + H2O - Mus musculus ? - ? 17205 3.4.24.18 Substance P + H2O - Homo sapiens ? - ? 17205 3.4.24.18 Substance P + H2O peptide of the gastrointestinal tract Mus musculus ? - ? 17205 3.4.24.18 Substance P + H2O in human small intestine Homo sapiens ? - ? 17205 3.4.24.18 Substance P + H2O in rat kidney Rattus norvegicus ? - ? 17205 3.4.24.18 Substance P + H2O human homomeric recombinant enzyme Homo sapiens ? - ? 17205 3.4.24.18 Substance P + H2O murine homomeric recombinant enzyme Mus musculus ? - ? 17205 3.4.24.18 Succinyl-Ala-Ala-Ala 4-nitroanilide + H2O arylamidolysis Mus musculus ? - ? 15439 3.4.24.18 Succinyl-Ala-Ala-Pro-Phe 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 9% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ? - ? 16628 3.4.24.18 Succinyl-Ala-Pro-Ala 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 2.8% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ? - ? 16629 3.4.24.18 Succinyl-Gly-Pro 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 10.7% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ? - ? 16630 3.4.24.18 Succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide + H2O - Homo sapiens ? - ? 15442 3.4.24.18 Succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide + H2O - Homo sapiens PPH ? - ? 15442 3.4.24.18 Succinyl-Leu-Tyr 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 5.6% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ? - ? 16631 3.4.24.18 tenascin-C + H2O an extracellular matrix-related substrate Mus musculus ? - ? 411029 3.4.24.18 tenascin-C + H2O an extracellular matrix-related substrate Homo sapiens ? - ? 411029 3.4.24.18 tissue growth factor-alpha + H2O meprin alpha can process tissue growth factor-alpha Homo sapiens ? - ? 413628 3.4.24.18 tumor necrosis factor alpha + H2O in rat kidney Rattus norvegicus ? - ? 389935 3.4.24.18 Tyr 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 3.3% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ? - ? 16633 3.4.24.18 Tyr-Leu-Val-Cys(SO3-)-Gly-Glu-Arg-Gly + H2O synthetic peptide derived from insulin B-chain Mus musculus ? - ? 16601 3.4.24.18 Tyr-Leu-Val-Cys(SO3-)-Gly-Glu-Arg-Gly + H2O synthetic peptide derived from insulin B-chain Mus musculus male ICR ? - ? 16601 3.4.24.18 valosin + H2O - Mus musculus ? - ? 367221 3.4.24.18 valosin + H2O peptide of the gastrointestinal tract Mus musculus ? - ? 367221 3.4.24.18 vascular endothelial growth factor A + H2O - Danio rerio ? - ? 432979 3.4.24.18 vascular endothelial growth factor-A + H2O - Danio rerio ? - ? 415436 3.4.24.18 vascular endothelial growth factor-A + H2O cleavage of the vascular endothelial growth factor-A monomer by meprin alpha yields in two distinct fragments of 19600 Da, the N-terminal cleavage site in human vascular endothelial growth factor-A165 is between Ala30 and Glu31 due to recombinant human meprin alpha activity Homo sapiens ? - ? 415436 3.4.24.18 Vasoactive intestinal peptide + H2O - Mus musculus ? - ? 15398 3.4.24.18 Vasoactive intestinal peptide + H2O peptide of the gastrointestinal tract Mus musculus ? - ? 15398 3.4.24.18 VEGF-A + H2O human meprin alpha cleaves VEGF-A in vitro, generating proteolytic fragments as found in wild-type zebrafish Homo sapiens ? - ? 434462 3.4.24.18 villin + H2O murine homomeric recombinant enzyme Mus musculus ? - ? 419185 3.4.24.18 vinculin + H2O substrate identified by 2D IEF/SDS-PAGE-based image analysis Canis lupus familiaris ? - ? 406874 3.4.24.18 [Met5]enkephalin-Arg6-Phe7 + H2O - Mus musculus ? - ? 16607 3.4.24.18 [Met5]enkephalin-Arg6-Phe7 + H2O - Homo sapiens ? - ? 16607 3.4.24.18 [Met5]enkephalin-Arg6-Phe7 + H2O - Rattus norvegicus ? - ? 16607