3.4.23.16 2-aminobenzoyl-Thr-Ile-Nle-4-nitro-Phe-Gln-Arg-NH2 + H2O - Human immunodeficiency virus 1 2-aminobenzoyl-Thr-Ile-Nle + 4-nitro-Phe-Gln-Arg-NH2 - ? 453124 3.4.23.16 2-aminobenzoyl-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2 + H2O - Human immunodeficiency virus 1 2-aminobenzoyl-Thr-Ile-Nle + p-nitro-Phe-Gln-Arg-NH2 - ? 411622 3.4.23.16 2-aminobenzoyl-TI-Nle-Phe(NO2)-ER + H2O - Human immunodeficiency virus 1 2-aminobenzoyl-Thr-Ile-Nle + Phe(NO2)-Glu-Arg - ? 363141 3.4.23.16 2-aminobenzoyl-TI-Nle-Phe(NO2)-QR + H2O - Human immunodeficiency virus 1 2-aminobenzoyl-Thr-Ile-Nle + Phe(NO2)-Gln-Arg - ? 363140 3.4.23.16 2-aminobenzoyl-TI-Nle-Phe(NO2)-QR-NH2 + H2O the enzyme reacts with the substrate to give an initial enzyme-substrate complex that isomerizes to a kinetically competent intermediate EX Human immunodeficiency virus 1 2-aminobenzoyl-Thr-Ile-Nle + Phe(NO2)-Gln-Arg-NH2 - ? 363139 3.4.23.16 4-(4-(dimethylamino)phenylazo)benzoyl-SQNYPIVQ-5-((2-aminoethyl)amino)naphthalene-1-sulfonic acid + H2O - Human immunodeficiency virus 1 ? - ? 363138 3.4.23.16 Abz-Ala-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2 + H2O - Human immunodeficiency virus 1 Abz-Ala-Arg-Val-Nle + (p-nitro)Phe-Phe-Glu-Ala-Nle-NH2 - ? 404131 3.4.23.16 Abz-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2 + H2O - Human immunodeficiency virus 1 Abz-Arg-Val-Nle + (p-nitro)Phe-Phe-Glu-Ala-Nle-NH2 - ? 404133 3.4.23.16 Abz-KARV-Nle-Phe(NO2)-EA-Nle-NH2 + H2O - Human immunodeficiency virus 1 Abz-KARV-Nle + Phe(NO2)-EA-Nle-NH2 - ? 363137 3.4.23.16 Abz-Lys-Ala-Arg-Val-Nle-(p-nitro)Phe-Phe-Glu-Ala-Nle-NH2 + H2O - Human immunodeficiency virus 1 Abz-Lys-Ala-Arg-Val-Nle + (p-nitro)Phe-Phe-Glu-Ala-Nle-NH2 - ? 404139 3.4.23.16 Abz-Thr-Ile-Nle-(p-nitro)Phe-Gln-Arg-NH2 + H2O - Human immunodeficiency virus 1 Abz-Thr-Ile-Nle + (p-nitro)Phe-Gln-Arg-NH2 - ? 404155 3.4.23.16 Abz-Thr-Ile-Nle-4-nitro-Phe-Gln-Arg-NH2 + H2O the fluorogenic peptide substrate Human immunodeficiency virus 1 Abz-Thr-Ile-Nle + 4-nitro-Phe-Gln-Arg-NH2 - ? 381296 3.4.23.16 Abz-Thr-Ile-Nle-Phe(NO2)-Gln-Arg + H2O - Human immunodeficiency virus 1 Abz-Thr-Ile-Nle + Phe(NO2)-Gln-Arg - ? 411511 3.4.23.16 Abz-Thr-Nle-Phe(NO2)-QR-NH2 + H2O - Human immunodeficiency virus 1 Abz-Thr-Ile-Nle + Phe(NO2)-Gln-Arg-NH2 - ? 363142 3.4.23.16 Ac-ARALAE-NH2 + H2O - Human immunodeficiency virus 1 Ac-ARAL + AE-NH2 - ? 362965 3.4.23.16 Ac-ATIMMQR-NH2 + H2O - Human immunodeficiency virus 1 Ac-ATIM + MQR-NH2 - ? 362966 3.4.23.16 Ac-HGWILAEHGD-NH2 + H2O - Human immunodeficiency virus 1 Ac-HGWIL + AEHGD-NH2 - ? 362973 3.4.23.16 Ac-KASQ(p-nitrophenylalanine)PPV-NH2 + H2O - Human immunodeficiency virus 1 Ac-KASQ + (4-nitro)FPPV-NH2 - ? 362967 3.4.23.16 Ac-RASQNYPVV-NH2 + H2O - Human immunodeficiency virus 1 Ac-RASQNY + PVV-NH2 - ? 362970 3.4.23.16 Ac-RKILFLDG-NH2 + H2O - Human immunodeficiency virus 1 Ac-RKIL + FLDG-NH2 - ? 362972 3.4.23.16 Ac-SQNYFLDG-NH2 + H2O - Human immunodeficiency virus 1 Ac-SQNY + FLDG-NH2 - ? 362974 3.4.23.16 Ac-SQNYPIV-NH2 + H2O - Human immunodeficiency virus 1 Ac-SQNY + PIV-NH2 - ? 363124 3.4.23.16 Ac-SQNYPVV-NH2 + H2O - Human immunodeficiency virus 1 Ac-SQNY + PVV-NH2 - ? 362969 3.4.23.16 Ac-SQNYPVVR + H2O - Human immunodeficiency virus 1 Ac-SQNY + PVVR - ? 362961 3.4.23.16 Ac-SQSYPVV-NH2 + H2O - Human immunodeficiency virus 1 Ac-SQSY + PVV-NH2 - ? 362971 3.4.23.16 Ac-TIMMQR-NH2 + H2O - Human immunodeficiency virus 1 Ac-TIM + MQR-NH2 - ? 362960 3.4.23.16 Ac-VSQNYPIV-NH2 + H2O - Human immunodeficiency virus 1 Ac-VSQNY + PIV-NH2 - ? 362962 3.4.23.16 Ac-YRARVFFVRAAK-biotin + H2O - Human immunodeficiency virus 1 ? - ? 362964 3.4.23.16 acetyl-KDKTK-Abz-VLF-NO2-VQPKK-NH2 + H2O - Human immunodeficiency virus 1 acetyl-KDKTK-Abz-VL + F-NO2-VQPKK-NH2 - ? 449510 3.4.23.16 AETFYVDG + H2O - Human immunodeficiency virus 1 ? - ? 362981 3.4.23.16 AETFYVDG + H2O - Human immunodeficiency virus 1 AETF + YVDG - ? 449528 3.4.23.16 AETFYVDGAA + H2O - Human immunodeficiency virus 1 AETF + YVDGAA - ? 391195 3.4.23.16 Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln Lys-(DABCYL)-Arg + H2O - Human immunodeficiency virus 1 ? - ? 418462 3.4.23.16 Arg-Glu(EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys(DABCYL)-Arg + H2O - Human immunodeficiency virus 1 ? - ? 411648 3.4.23.16 Arg-Glu-[5-[(2'-aminoethyl)-amino]naphthalenesulfonyl]-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys-[4-[[4'-(dimethylamino)phenyl]azo]-benzoyl]-Arg + H2O - Human immunodeficiency virus 1 ? - ? 363145 3.4.23.16 Arg-Pro-Gly-Asn-Phe-Leu-Gln-Ser-Arg-Pro + H2O decameric p1-p6 peptide Human immunodeficiency virus 1 ? - ? 404356 3.4.23.16 ARVLAEAM + H2O - Human immunodeficiency virus 1 ARVL + AEAM - ? 362976 3.4.23.16 ATHDVY-Phe(NO2)-VRKA + H2O - Human immunodeficiency virus 1 ATHDVY + Phe(NO2)-VRKA - ? 363066 3.4.23.16 ATHNVY-Phe(NO2)-VRKA + H2O - Human immunodeficiency virus 1 ATHNVY + Phe(NO2)-VRKA - ? 363067 3.4.23.16 ATHQVY-Phe(NO2)-VRKA + H2O - Human immunodeficiency virus 1 ATHQVY + Phe(NO2)-VRKA - ? 363064 3.4.23.16 ATHRVY-Phe(NO2)-VRKA + H2O - Human immunodeficiency virus 1 ATHRVY + Phe(NO2)-VRKA - ? 363065 3.4.23.16 ATHVVY-Phe(NO2)-VRKA + H2O - Human immunodeficiency virus 1 ATHVVY + Phe(NO2)-VRKA - ? 363068 3.4.23.16 ATHYVY-Phe(NO2)-VRKA + H2O - Human immunodeficiency virus 1 ATHYVY + Phe(NO2)-VRKA - ? 363063 3.4.23.16 ATIMMQRG + H2O - Human immunodeficiency virus 1 ATIM + MQRG - ? 362977 3.4.23.16 B-chain of oxidized insulin + H2O - Human immunodeficiency virus 1 ? - ? 362984 3.4.23.16 beta-secretase + H2O expression of beta-secretase in mammalian host cells leads to full-length pro-form and the processed enzyme missing the first 24 amino acids and beginning with residue E25. Protease treatment of the mixture results in complete cleavage of the F39-V40 bond Human immunodeficiency virus 1 truncated beta-secretase protein + peptide E25-F39 - ? 404525 3.4.23.16 beta-secretase precursor protein + H2O expression of beta-secretase in mammalian host cells leads to full-length pro-form and the processed enzyme missing the first 24 amino acids and beginning with residue E25. Protease treatment of the mixture results in complete cleavage of the F39-V40 bond Human immunodeficiency virus 1 truncated beta-secretase protein + peptide T1-F39 - ? 404526 3.4.23.16 capsid-p2 protein + H2O - Human immunodeficiency virus 1 ? - ? 418533 3.4.23.16 CTLNFPISP + H2O - Human immunodeficiency virus 1 CTLNF + PISP - ? 363132 3.4.23.16 DABCYL-(gamma-Abu)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS + H2O - Human immunodeficiency virus 1 ? - ? 411959 3.4.23.16 DCAWLEAQ + H2O - Human immunodeficiency virus 1 DCAW + LEAQ - ? 449850 3.4.23.16 DTVIEEMS + H2O - Human immunodeficiency virus 1 DTVI + EEMS - ? 362992 3.4.23.16 DTVLEEMS + H2O - Human immunodeficiency virus 1 DTVL + EEMS - ? 362990 3.4.23.16 DTVVEEMS + H2O - Human immunodeficiency virus 1 DTVV + EEMS - ? 362991 3.4.23.16 DTVVEKMS + H2O - Human immunodeficiency virus 1 DTVV + EKMS - ? 362993 3.4.23.16 eIF4GI + H2O perhaps cleavage of eIF4G is an event that contributes to a more efficient translation of the genomic HIV-1 mRNA, proteolysis of eIF4GI inhibits protein synthesis directed by capped mRNAs but allows internal ribosome entry site-driven translation, purified enzyme cleaves at positions 678-679, 681-682 and 1086-1087, separating the three domains of the initiation factor Human immunodeficiency virus 1 ? - ? 370623 3.4.23.16 elF4GI + H2O purified enzyme cleaves at positions 678-679, 681-682 and 1086-1087, separating the three domains of the initiation factor Human immunodeficiency virus 1 additional information - ? 363146 3.4.23.16 GAETFYVDGAA + H2O - Human immunodeficiency virus 1 GAETF + YVDGAA - ? 363133 3.4.23.16 Gag polyprotein + H2O - Human immunodeficiency virus 1 ? - ? 380606 3.4.23.16 Gag polyprotein + H2O substrate sites, overview Human immunodeficiency virus 1 ? - ? 380606 3.4.23.16 Gag polyprotein + H2O CA/p2 cleavage site is KARVL*AEAMS Human immunodeficiency virus 1 ? - ? 380606 3.4.23.16 Gag polyprotein + H2O Gag polyprotein with cleavage-site P12-P5/P5'-P12' residues Human immunodeficiency virus 1 matrix-capsid polyprotein + ? - ? 448594 3.4.23.16 Gag precursor polyprotein + H2O - Human immunodeficiency virus 1 mature Gag polyprotein + ? - ? 448595 3.4.23.16 Gag precursor protein + H2O five different cleavage sites, the p2-NC-site is the first, the CA/p2 the last one in sequential processing of the precursor Human immunodeficiency virus 1 ? - ? 381905 3.4.23.16 Gag protein + H2O proteolytic cleavage in the host cell cytoplasm Human immunodeficiency virus 1 ? - ? 380607 3.4.23.16 Gag protein + H2O site-specific proteolytic cleavage of the protein precursor Human immunodeficiency virus 1 ? - ? 380607 3.4.23.16 Gag-Pol polyprotein + H2O - Human immunodeficiency virus 1 ? - ? 380608 3.4.23.16 Gag-Pol polyprotein + H2O proteolytic cleavage in the host cell cytoplasm Human immunodeficiency virus 1 ? - ? 380608 3.4.23.16 Gag-Pol polyprotein + H2O NC/p1 cleavage site is ERQAN*FLGKI Human immunodeficiency virus 1 ? - ? 380608 3.4.23.16 Gag-Pol polyprotein + H2O site-specific proteolytic cleavage of the protein precursor Human immunodeficiency virus 1 ? - ? 380608 3.4.23.16 Gag-Pol precursor polyprotein + H2O - Human immunodeficiency virus 1 mature Gag-Pol polyprotein + ? - ? 448596 3.4.23.16 Gag-pro-pol polyprotein + H2O - Human immunodeficiency virus 1 ? - ? 448597 3.4.23.16 GagPol polyprotein + H2O - Human immunodeficiency virus 1 ? - ? 380609 3.4.23.16 H-Lys-Ala-Arg-Val-Tyr-Phe(4-NO2)-Glu-Ala-Nle-NH2 + H2O - Human immunodeficiency virus 1 Lys-Ala-Arg-Val-Tyr + Phe(4-NO2)-Glu-Ala-Nle-NH2 - ? 392178 3.4.23.16 His-Lys-Ala-Arg-Val-Leu-(4-nitro)Phe-Glu-Ala-Nle-Ser-amide + H2O - Human immunodeficiency virus 1 His-Lys-Ala-Arg-Val-Leu + (4-nitro)Phe-Glu-Ala-Nle-Ser-amide - ? 362986 3.4.23.16 His-Lys-Ala-Arg-Val-Leu-(p-NO2-Phe)-Glu-Ala-Nle-Ser-NH2 + H2O - Human immunodeficiency virus 1 His-Lys-Ala-Arg-Val-Leu + (p-NO2-Phe)-Glu-Ala-Nle-Ser-NH2 - ? 412159 3.4.23.16 His-Lys-Ala-Arg-Val-Leu-(pNO2-Phe)-Glu-Ala-Ile-Ser-NH2 + H2O - Human immunodeficiency virus 1 His-Lys-Ala-Arg-Val-Leu + (pNO2-Phe)-Glu-Ala-Ile-Ser-NH2 - ? 412160 3.4.23.16 His-Lys-Ala-Arg-Val-Leu-(pNO2-Phe)-Glu-Ala-Nle-Ser-NH2 + H2O - Human immunodeficiency virus 1 ? - ? 392216 3.4.23.16 HIV-1 Gag-Pol polyprotein + H2O site-specific proteolytic cleavage, protein precursors and peptides derived thereof Human immunodeficiency virus 1 ? - ? 382030 3.4.23.16 HIV-2 Gag-Pol poylprotein + H2O site-specific proteolytic cleavage, protein precursors and peptides derived thereof Human immunodeficiency virus 1 ? - ? 382032 3.4.23.16 HKARVLAEAMS + H2O - Human immunodeficiency virus 1 HKARVL + AEAMS - ? 363126 3.4.23.16 IPFAAAQQRK + H2O the protein contains a HIV-2 cleavage site Human immunodeficiency virus 1 IPFAA + AQQRK - ? 359023 3.4.23.16 IRKILFLDG + H2O - Human immunodeficiency virus 1 IRKIL + FLDG - ? 359020 3.4.23.16 KAQNYPIA-Nle + H2O - Human immunodeficiency virus 1 KAQNY + PIA-Nle - ? 363056 3.4.23.16 KAQNYPIV-Nle + H2O - Human immunodeficiency virus 1 KAQNY + PIV-Nle - ? 363055 3.4.23.16 KARA-Nle-Phe(NO2)-EA-Nle + H2O - Human immunodeficiency virus 1 KARA-Nle + Phe(NO2)-EA-Nle - ? 363084 3.4.23.16 KARI-Nle-Phe(NO2)-EA-Nle + H2O - Human immunodeficiency virus 1 KARI-Nle + Phe(NO2)-EA-Nle - ? 363082 3.4.23.16 KARL-Nle-Phe(NO2)-EA-Nle + H2O - Human immunodeficiency virus 1 KARL-Nle + Phe(NO2)-EA-Nle - ? 363083 3.4.23.16 KARLMAEALK + H2O the protein contains a HIV-2 cleavage site Human immunodeficiency virus 1 KARLM + AEALK - ? 359022 3.4.23.16 KARN-Nle-Phe(NO2)-EA-Nle + H2O - Human immunodeficiency virus 1 KARN-Nle + Phe(NO2)-EA-Nle - ? 363085 3.4.23.16 KARNYPA-Nle + H2O - Human immunodeficiency virus 1 KARNY + PA-Nle - ? 363052 3.4.23.16 KARNYPE-Nle + H2O - Human immunodeficiency virus 1 KARNY + PE-Nle - ? 363048 3.4.23.16 KARNYPI-Nle + H2O - Human immunodeficiency virus 1 KARNY + PI-Nle - ? 363049 3.4.23.16 KARNYPN-Nle + H2O - Human immunodeficiency virus 1 KARNY + PN-Nle - ? 363051 3.4.23.16 KARNYPQ-Nle + H2O - Human immunodeficiency virus 1 KARNY + PQ-Nle - ? 363050 3.4.23.16 KARNYPV-Nle + H2O - Human immunodeficiency virus 1 KARNY + PV-Nle - ? 363053 3.4.23.16 KARV-Nle-Phe(NO2)-AA-Nle + H2O - Human immunodeficiency virus 1 KARV-Nle + Phe(NO2)-AA-Nle - ? 363111 3.4.23.16 KARV-Nle-Phe(NO2)-EA-Nle + H2O - Human immunodeficiency virus 1 KARV-Nle + Phe(NO2)-EA-Nle - ? 363081 3.4.23.16 KARV-Nle-Phe(NO2)-EA-Nle-NH2 + H2O - Human immunodeficiency virus 1 KARV-Nle + Phe(NO2)-EA-Nle-NH2 - ? 363123 3.4.23.16 KARV-Nle-Phe(NO2)-IA-Nle + H2O - Human immunodeficiency virus 1 KARV-Nle + Phe(NO2)-IA-Nle - ? 363110 3.4.23.16 KARV-Nle-Phe(NO2)-NA-Nle + H2O - Human immunodeficiency virus 1 KARV-Nle + Phe(NO2)-NA-Nle - ? 363115 3.4.23.16 KARV-Nle-Phe(NO2)-QA-Nle + H2O - Human immunodeficiency virus 1 KARV-Nle + Phe(NO2)-QA-Nle - ? 363113 3.4.23.16 KARV-Nle-Phe(NO2)-TA-Nle + H2O - Human immunodeficiency virus 1 KARV-Nle + Phe(NO2)-TA-Nle - ? 363114 3.4.23.16 KARV-Nle-Phe(NO2)-VA-Nle + H2O - Human immunodeficiency virus 1 KARV-Nle + Phe(NO2)-VA-Nle - ? 363112 3.4.23.16 KARVL-Phe(NO2)-EAM + H2O - Human immunodeficiency virus 1 KARVL + Phe(NO2)-EAM - ? 363125 3.4.23.16 KARVLAEAMS + H2O - Human immunodeficiency virus 1 KARVL + AEAMS - ? 359014 3.4.23.16 KARVMPhe(NO2)-EA-Nle + H2O - Human immunodeficiency virus 1 KARVM + Phe(NO2)-EA-Nle - ? 363087 3.4.23.16 KARVYPhe(NO2)-EA-Nle + H2O - Human immunodeficiency virus 1 KARVY + Phe(NO2)-EA-Nle - ? 363086 3.4.23.16 KGRPGNFLQSRP + H2O - Human immunodeficiency virus 1 KGRPGNF + LQSRP - ? 363136 3.4.23.16 KLRPGNFLQSRP + H2O - Human immunodeficiency virus 1 KLRPGNF + LQSRP - ? 363129 3.4.23.16 Lys-Ala-Arg-Val-Leu-4-nitro-Phe-Glu-Ala-Nle-Gly + H2O i.e. substrate L6525, the peptide substrate contains the CA-p2 cleavage site Human immunodeficiency virus 1 Lys-Ala-Arg-Val-Leu + 4-nitro-Phe-Glu-Ala-Nle-Gly - ? 382222 3.4.23.16 Lys-Ala-Arg-Val-Leu-4-nitro-Phe-Glu-Ala-Nle-Gly + H2O the peptide substrate mimicks the CA-p2 cleavage site Human immunodeficiency virus 1 Lys-Ala-Arg-Val-Leu + 4-nitro-Phe-Glu-Ala-Nle-Gly - ? 382222 3.4.23.16 Lys-Ala-Arg-Val-Leu-Ala-Glu-Ala-Met + H2O in the protease-substrate complex the highest fluctuations correspond to the 17- and 39-turns and the substrate motion is anticorrelated with the 39-turn. The active site residues and the flap tips move in phase with the peptide Human immunodeficiency virus 1 ? - ? 392501 3.4.23.16 Lys-Ala-Arg-Val-Leu-Phe(NO2)-Glu-Ala-Met + H2O - Human immunodeficiency virus 1 Lys-Ala-Arg-Val-Leu + Phe(NO2)-Glu-Ala-Met - ? 418809 3.4.23.16 Lys-Ala-Arg-Val-Nle-(4-nitrophenylalanine)-Glu-Ala-Nle-NH2 + H2O - Human immunodeficiency virus 1 Lys-Ala-Arg-Val-Nle + (4-nitrophenylalanine)-Glu-Ala-Nle-NH2 - ? 392502 3.4.23.16 Lys-Ala-Arg-Val-Nle-(p-nitro-Phe)-Glu-Ala-Nle-amide + H2O - Human immunodeficiency virus 1 Lys-Ala-Arg-Val-Nle + (p-nitro-Phe)-Glu-Ala-Nle-amide - ? 412393 3.4.23.16 Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amide + H2O the peptide substrate mimicks the CA-p2 cleavage site Human immunodeficiency virus 1 Lys-Ala-Arg-Val-Nle + 4-nitro-Phe-Glu-Ala-Nle-amide - ? 382223 3.4.23.16 Lys-Ala-Arg-Val-Nle-4-nitro-Phe-Glu-Ala-Nle-amide + H2O the peptide substrate mimicks the HIV-1 CA/p2 cleavage site Human immunodeficiency virus 1 Lys-Ala-Arg-Val-Nle + 4-nitro-Phe-Glu-Ala-Nle-amide - ? 382223 3.4.23.16 Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-Gly + H2O - Human immunodeficiency virus 1 Lys-Ala-Arg-Val-Nle + Phe(4-NO2)-Glu-Ala-Nle-Gly - ? 392504 3.4.23.16 Lys-Ala-Arg-Val-Nle-Phe(4-NO2)-Glu-Ala-Nle-NH2 + H2O - Human immunodeficiency virus 1 Lys-Ala-Arg-Val-Nle + Phe(4-NO2)-Glu-Ala-Nle-NH2 - ? 392505 3.4.23.16 Lys-Ala-Arg-Val-Tyr-p-nitro-Phe-Glu-Ala-Ile-NH2 + H2O - Human immunodeficiency virus 1 ? - ? 362985 3.4.23.16 matrix-capsid polyprotein + H2O i.e. DTGNNSQVSQNYPIVQNLQGQMVH Human immunodeficiency virus 1 DTGNNSQVSQNY + PIVQNLQGQMVH - ? 448759 3.4.23.16 matrix-capsid protein + H2O - Human immunodeficiency virus 1 ? - ? 418822 3.4.23.16 Moloney murine sarcoma virus-derived gag protein + H2O - Human immunodeficiency virus 1 ? - ? 362983 3.4.23.16 additional information insertion of human immunodeficiency virus type 1 protease substrate sequences into the permissive sites converts thymidylate synthase to an HIV-1 protease substrate Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information autocatalytic maturation, two temporally regulated N-terminal cleavages, first at the native TFP/p6pol followed by cleavage at the p6pol/PR, are crucial for protease maturation and enzymatic activity Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information the enzyme exhibits autoprocessing Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information artificial neural network method for predicting HIV protease cleavage sites in protein Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information sequences surrounding HIV-1 protease cleavage sites in several viral and nonviral protein substrates. No amino acid is required at any of the eight positions of the substrate. The highest preference is seen for glutamate at P2' followed by Phe at P1 Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information the cleavage site involves a Phe or Tyr as the N-terminal P1 side and a Pro as the C-terminal P1' side of the scissile bond Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information the minimum length of effective HIV-1 protease substrate is seven amino acid residues Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information autoprocessing of the mature protease from the precursor can either occur in two steps at pH values of 4 to 6 or in a single step above pH 6 Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information the enzyme plays an essential role in the late-stage maturation step of the virus replication cycle. HIV-1 proteinase autocatalyzes its own cleavage from the Pr165 polyprotein precursor and then cleaves both polyproteins at other specific sites to produce mature proteins Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information regulation of the protease in the viral life cycle: transframe region flanking the N-terminus of the protease may function as a negative regulator for protein folding and dimerization. The low dimer stability of the protease precursor relative to that of the mature enzyme is an ideal way of preventing the emergence of enzymatic functions until assembly of the viral particle is complete Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information the enzyme is responsible for the processing of gag and gag-pol polyprotein precursors to produce structural proteins and enzymes for the mature virus Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information the enzyme facilitates viral maturation by cleaving ten asymmetric and nonhomologous sequences in the Gag and Pol polyproteins Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information the enzyme is essential for the replication of the virus Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information the enzyme is involved in regulation of the incorporation of reverse transcriptase in the viral early assembly complex comprising reverse transcriptase, genomic RNA, Gag, Gag-Pol, tRNALys, and lysyl tRNA synthetase, HIV-1 protease activity is negatively regulated by the lysyl tRNA synthetase Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information amino acid preferences for the critical P2' substrate binding subsite in type 1 cleavage sites, molecular modeling and phylogenetic comparison, overview Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information molecular basis for substrate recognition and drug resistance Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information substrate and cleavage site sequence specificity, overview, drug resistance occasionally confers a change in substrate specificity, prediction of substrate specificity by three-dimensional structure analysis, detailed overview Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information substrate specificity and kinetics of wild-type and mutant enzymes, overview Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information comparison of protease specificities for P1, P3, P4 cleaving positions of proteases of HIV-1, HIV-2, equine infectious anemia virus, avian myeloblastosis virus, Mason-Pfizer monkey virus, mouse mammary tumor virus, Moloney murine leukemia virus, human T-lymphotropic virus type 1, bovine leukemia virus, walleye dermal sarcoma virus, and human foamy virus. The retroviral proteases have similar preferences for Phe and Tyr for the P1 position in this sequence context. The sizes of the P3 and P4 residues appear to be a major contributor for specificity Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information Arg-Val-Leu-Ala-Glu-Ala-Met mimics the real substrate Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 additional information the enzyme prefers to have large hydrophobic amino acids flanking the scissile bond. When P1' is proline, the P2 side chain interacts with a polar region in the S2 subsite of the enzyme, while the P2' amino acid interacts with a hydrophobic region of the S2' subsite. When P1' is not proline, the orientations of the P2 and P2' side chains with respect to the scissile bond are reversed. P2 residues interact with a hydrophobic face of the S2 subsite, while the P2' amino acid usually engages hydrophilic amino acids in the S2' subsite Human immunodeficiency virus 1 ? - ? 89 3.4.23.16 N-dansyl-SQNYPIV + H2O - Human immunodeficiency virus 1 ? - ? 362963 3.4.23.16 NLAFPQGE + H2O - Human immunodeficiency virus 1 NLAF + PQG - ? 450411 3.4.23.16 nucleocapsid protein + H2O - Human immunodeficiency virus 1 ? - ? 390273 3.4.23.16 nucleocapsid protein + H2O characterization of human immunodeficiency virus type 1 containing mutations in the nucleocapsid protein at a putative HIV-1 protease cleavage site Human immunodeficiency virus 1 ? - ? 390273 3.4.23.16 nucleocapsid-p1 protein + H2O - Human immunodeficiency virus 1 ? - ? 418975 3.4.23.16 p1-p6 protein + H2O - Human immunodeficiency virus 1 ? - ? 418987 3.4.23.16 p2-nucleocapsid protein + H2O - Human immunodeficiency virus 1 ? - ? 418988 3.4.23.16 PAFVLAEAMR + H2O - Human immunodeficiency virus 1 PAFVL + AEAMR - ? 363117 3.4.23.16 PAFVLMEAMR + H2O - Human immunodeficiency virus 1 ? - ? 454026 3.4.23.16 PARVLAEAMR + H2O - Human immunodeficiency virus 1 PARVL + AEAMR - ? 363116 3.4.23.16 PARVLFEAMR + H2O - Human immunodeficiency virus 1 PARVL + FEAMR - ? 363120 3.4.23.16 PARVLIEAMR + H2O - Human immunodeficiency virus 1 PARVL + IEAMR - ? 363122 3.4.23.16 PARVLLAEAMR + H2O - Human immunodeficiency virus 1 PARVL + LAEAMR - ? 453125 3.4.23.16 PARVLLEAMR + H2O - Human immunodeficiency virus 1 PARVL + LEAMR - ? 363119 3.4.23.16 PARVLMEAMR + H2O - Human immunodeficiency virus 1 PARVL + MEAMR - ? 363118 3.4.23.16 PARVLVEAMR + H2O - Human immunodeficiency virus 1 PARVL + VEAMR - ? 363121 3.4.23.16 PFAVSLAMTMRR + H2O - Human immunodeficiency virus 1 PFAVS + LAMTMRR - ? 363061 3.4.23.16 PGAVSLAMTMRR + H2O - Human immunodeficiency virus 1 PGAVS + LAMTMRR - ? 363059 3.4.23.16 PGNFLESR + H2O - Human immunodeficiency virus 1 PGNF + LESR - ? 362978 3.4.23.16 PGNFLQSR + H2O - Human immunodeficiency virus 1 PGNF + LQSR - ? 450453 3.4.23.16 PHAVSLAMTMRR + H2O - Human immunodeficiency virus 1 PHAVS + LAMTMRR - ? 362423 3.4.23.16 PLAVSLAMTMRR + H2O - Human immunodeficiency virus 1 PLAVS + LAMTMRR - ? 363062 3.4.23.16 PNAVSLAMTMRR + H2O - Human immunodeficiency virus 1 PNAVS + LAMTMRR - ? 363060 3.4.23.16 Pol polyprotein + H2O substrate sites, overview Human immunodeficiency virus 1 ? - ? 380728 3.4.23.16 Poly(A)-binding protein + H2O - Human immunodeficiency virus 1 ? - ? 385564 3.4.23.16 PPAGSLAMTMRR + H2O - Human immunodeficiency virus 1 PPAGS + LAMTMRR - ? 363077 3.4.23.16 PPAHSLAMTMRR + H2O - Human immunodeficiency virus 1 PPAHS + LAMTMRR - ? 363080 3.4.23.16 PPALSLAMTMRR + H2O - Human immunodeficiency virus 1 PPALS + LAMTMRR - ? 363076 3.4.23.16 PPASSLAMTMRR + H2O - Human immunodeficiency virus 1 PPASS + LAMTMRR - ? 363078 3.4.23.16 PPAVALAMTMRR + H2O - Human immunodeficiency virus 1 PPAVA + LAMTMRR - ? 362434 3.4.23.16 PPAVELAMTMRR + H2O - Human immunodeficiency virus 1 PPAVE + LAMTMRR - ? 362432 3.4.23.16 PPAVGLAMTMRR + H2O - Human immunodeficiency virus 1 PPAVG + LAMTMRR - ? 363095 3.4.23.16 PPAVHLAMTMRR + H2O - Human immunodeficiency virus 1 PPAVH + LAMTMRR - ? 362433 3.4.23.16 PPAVLLAMTMRR + H2O - Human immunodeficiency virus 1 PPAVL + LAMTMRR - ? 362430 3.4.23.16 PPAVRLAMTMRR + H2O - Human immunodeficiency virus 1 PPAVR + LAMTMRR - ? 362431 3.4.23.16 PPAVSEAMTMRR + H2O - Human immunodeficiency virus 1 PPAVS + EAMTMRR - ? 363101 3.4.23.16 PPAVSFAMTMRR + H2O - Human immunodeficiency virus 1 PPAVS + FAMTMRR - ? 363098 3.4.23.16 PPAVSGAMTMRR + H2O - Human immunodeficiency virus 1 PPAVS + GAMTMRR - ? 363102 3.4.23.16 PPAVSLALTMRR + H2O - Human immunodeficiency virus 1 PPAVS + LALTMRR - ? 363103 3.4.23.16 PPAVSLAMTMRR + H2O - Human immunodeficiency virus 1 PPAVS + LAMTMRR - ? 362422 3.4.23.16 PPAVSLANTMRR + H2O - Human immunodeficiency virus 1 PPAVS + LANTMRR - ? 363105 3.4.23.16 PPAVSLAYTMRR + H2O - Human immunodeficiency virus 1 PPAVS + LAYTMRR - ? 363104 3.4.23.16 PPAVSLGMTMRR + H2O - Human immunodeficiency virus 1 PPAVS + LGMTMRR - ? 363108 3.4.23.16 PPAVSLHMTMRR + H2O - Human immunodeficiency virus 1 PPAVS + LHMTMRR - ? 363109 3.4.23.16 PPAVSLLMTMRR + H2O - Human immunodeficiency virus 1 PPAVS + LLMTMRR - ? 363106 3.4.23.16 PPAVSLSMTMRR + H2O - Human immunodeficiency virus 1 PPAVS + LSMTMRR - ? 363107 3.4.23.16 PPAVSQAMTMRR + H2O - Human immunodeficiency virus 1 PPAVS + QAMTMRR - ? 363100 3.4.23.16 PPAVSRAMTMRR + H2O - Human immunodeficiency virus 1 PPAVS + RAMTMRR - ? 363099 3.4.23.16 PPAVWLAMTMRR + H2O - Human immunodeficiency virus 1 PPAVW + LAMTMRR - ? 362429 3.4.23.16 PPAWSLAMTMRR + H2O - Human immunodeficiency virus 1 PPAWS + LAMTMRR - ? 363079 3.4.23.16 PPDVSLAMTMRR + H2O - Human immunodeficiency virus 1 PPDVS + LAMTMRR - ? 362428 3.4.23.16 PPFVSLAMTMRR + H2O - Human immunodeficiency virus 1 PPFVS + LAMTMRR - ? 362425 3.4.23.16 PPGVSLAMTMRR + H2O - Human immunodeficiency virus 1 PPGVS + LAMTMRR - ? 363072 3.4.23.16 PPHVSLAMTMRR + H2O - Human immunodeficiency virus 1 PPHVS + LAMTMRR - ? 362427 3.4.23.16 PPNVSLAMTMRR + H2O - Human immunodeficiency virus 1 PPNVS + LAMTMRR - ? 362426 3.4.23.16 PPPVSLAMTMRR + H2O - Human immunodeficiency virus 1 PPPVS + LAMTMRR - ? 363070 3.4.23.16 PPRVSLAMTMRR + H2O - Human immunodeficiency virus 1 PPRVS + LAMTMRR - ? 362424 3.4.23.16 PQITLWKRP + H2O - Human immunodeficiency virus 1 PQITL + WKRP - ? 362989 3.4.23.16 PQITLWQRP + H2O - Human immunodeficiency virus 1 PQITL + WQRP - ? 362988 3.4.23.16 reverse transcriptase-RNaseH protein + H2O - Human immunodeficiency virus 1 ? - ? 419035 3.4.23.16 REYDQIIIEVS + H2O - Human immunodeficiency virus 1 REYDQII + IEVS - ? 362996 3.4.23.16 REYDQILIEVS + H2O - Human immunodeficiency virus 1 REYDQIL + IEVS - ? 362994 3.4.23.16 REYDQILIKVS + H2O - Human immunodeficiency virus 1 REYDQIL + IKVS - ? 362995 3.4.23.16 RKILFLDG + H2O - Human immunodeficiency virus 1 RKIL + FLDG - ? 362982 3.4.23.16 RKVLFLDG + H2O - Human immunodeficiency virus 1 RKVL + FLDG - ? 450557 3.4.23.16 RNaseH-integrase protein + H2O - Human immunodeficiency virus 1 ? - ? 419038 3.4.23.16 RQANFLGK + H2O - Human immunodeficiency virus 1 RQAN + FLGK - ? 450559 3.4.23.16 RQANFLRE + H2O - Human immunodeficiency virus 1 RQAN + FLRE - ? 450560 3.4.23.16 RQGTVSFNFPQITL + H2O - Human immunodeficiency virus 1 RQGTVSFNF + PQITL - ? 363130 3.4.23.16 SANYPIV + H2O - Human immunodeficiency virus 1 SANY + PIV - ? 363021 3.4.23.16 SCNYPIV + H2O - Human immunodeficiency virus 1 SCNY + PIV - ? 363028 3.4.23.16 SDNYPIV + H2O - Human immunodeficiency virus 1 SDNY + PIV - ? 363025 3.4.23.16 SENYPIV + H2O - Human immunodeficiency virus 1 SENY + PIV - ? 363022 3.4.23.16 SFNFPQIT + H2O - Human immunodeficiency virus 1 SFNF + PQIT - ? 362979 3.4.23.16 SFNYPIV + H2O - Human immunodeficiency virus 1 SFNY + PIV - ? 363014 3.4.23.16 SGIFLETS + H2O - Human immunodeficiency virus 1 ? - ? 450623 3.4.23.16 SGNYPIV + H2O - Human immunodeficiency virus 1 SGNY + PIV - ? 363027 3.4.23.16 SHNYPIV + H2O - Human immunodeficiency virus 1 SHNY + PIV - ? 363020 3.4.23.16 SINYPIV + H2O - Human immunodeficiency virus 1 SINY + PIV - ? 363030 3.4.23.16 SKNYPIV + H2O - Human immunodeficiency virus 1 SKNY + PIV - ? 363026 3.4.23.16 SLNYPIV + H2O - Human immunodeficiency virus 1 SLNY + PIV - ? 363029 3.4.23.16 SMNYPIV + H2O - Human immunodeficiency virus 1 SMNY + PIV - ? 363012 3.4.23.16 SNNYPIV + H2O - Human immunodeficiency virus 1 SNNY + PIV - ? 363023 3.4.23.16 SQAYPIV + H2O - Human immunodeficiency virus 1 SQAY + PIV - ? 363033 3.4.23.16 SQCYPIV + H2O - Human immunodeficiency virus 1 SQCY + PIV - ? 363032 3.4.23.16 SQDYPIV + H2O - Human immunodeficiency virus 1 SQDY + PIV - ? 363031 3.4.23.16 SQEYPIV + H2O - Human immunodeficiency virus 1 SQEY + PIV - ? 363034 3.4.23.16 SQNFPIV + H2O - Human immunodeficiency virus 1 SQNF + PIV - ? 363036 3.4.23.16 SQNLPIV + H2O - Human immunodeficiency virus 1 SQNL + PIV - ? 363038 3.4.23.16 SQNMPIV + H2O - Human immunodeficiency virus 1 SQNM + PIV - ? 363039 3.4.23.16 SQNWPIV + H2O - Human immunodeficiency virus 1 SQNW + PIV - ? 363037 3.4.23.16 SQNYAIV + H2O - Human immunodeficiency virus 1 SQNY + AIV - ? 363045 3.4.23.16 SQNYFIV + H2O - Human immunodeficiency virus 1 SQNY + FIV - ? 363042 3.4.23.16 SQNYIIV + H2O - Human immunodeficiency virus 1 SQNY + IIV - ? 363047 3.4.23.16 SQNYLIV + H2O - Human immunodeficiency virus 1 SQNY + LIV - ? 363041 3.4.23.16 SQNYMIV + H2O - Human immunodeficiency virus 1 SQNY + MIV - ? 363043 3.4.23.16 SQNYPAV + H2O - Human immunodeficiency virus 1 SQNY + PAV - ? 363097 3.4.23.16 SQNYPIV + H2O - Human immunodeficiency virus 1 SQNY + PIV - ? 362588 3.4.23.16 SQNYPIVQ + H2O - Human immunodeficiency virus 1 SQNY + PIVQ - ? 362546 3.4.23.16 SQNYPLV + H2O - Human immunodeficiency virus 1 SQNY + PLV - ? 363096 3.4.23.16 SQNYVIV + H2O - Human immunodeficiency virus 1 SQNY + VIV - ? 363044 3.4.23.16 SQNYWIV + H2O - Human immunodeficiency virus 1 SQNY + WIV - ? 363046 3.4.23.16 SQNYYIV + H2O - Human immunodeficiency virus 1 SQNY + YIV - ? 363040 3.4.23.16 SQVYPIV + H2O - Human immunodeficiency virus 1 SQVY + PIV - ? 363035 3.4.23.16 SRNYPIV + H2O - Human immunodeficiency virus 1 SRNY + PIV - ? 363016 3.4.23.16 SSNYPIV + H2O - Human immunodeficiency virus 1 SSNY + PIV - ? 363024 3.4.23.16 STNYPIV + H2O - Human immunodeficiency virus 1 STNY + PIV - ? 363013 3.4.23.16 SWNYPIV + H2O - Human immunodeficiency virus 1 SWNY + PIV - ? 363017 3.4.23.16 SYNYPIV + H2O - Human immunodeficiency virus 1 SYNY + PIV - ? 363015 3.4.23.16 TATIMMQRGN + H2O - Human immunodeficiency virus 1 TATIM + MQRGN - ? 359015 3.4.23.16 TFQA(p-nitrophenylalanine)PLREA + H2O - Human immunodeficiency virus 1 ? - ? 362968 3.4.23.16 TLNFPISP + H2O - Human immunodeficiency virus 1 TLNF + PISP - ? 362980 3.4.23.16 TLNFPISPKK + H2O - Human immunodeficiency virus 1 TLNF + PISPKK - ? 362420 3.4.23.16 TLNFPQIT + H2O - Human immunodeficiency virus 1 TLNF + PQIT - ? 450769 3.4.23.16 TNIMMQKS + H2O - Human immunodeficiency virus 1 TNIM + MQKS - ? 450770 3.4.23.16 translation initiation factor eIF4GI + H2O - Human immunodeficiency virus 1 ? - ? 411039 3.4.23.16 Val-Ser-Gln-Ala-Tyr-Pro-Ile-Val-Gln + H2O - Human immunodeficiency virus 1 Val-Ser-Gln-Ala-Tyr + Pro-Ile-Val-Gln - ? 382942 3.4.23.16 Val-Ser-Gln-Asn-(2-naphthylalanine)-Pro-Ile-Val + H2O - Human immunodeficiency virus 1 ? - ? 419182 3.4.23.16 Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln + H2O - Human immunodeficiency virus 1 Val-Ser-Gln-Asn-Tyr + Pro-Ile-Val-Gln - ? 382943 3.4.23.16 Val-Ser-Gln-Cys-Tyr-Pro-Ile-Val-Gln + H2O - Human immunodeficiency virus 1 Val-Ser-Gln-Cys-Tyr + Pro-Ile-Val-Gln - ? 382944 3.4.23.16 Val-Ser-Gln-Gly-Tyr-Pro-Ile-Val-Gln + H2O - Human immunodeficiency virus 1 Val-Ser-Gln-Gly-Tyr + Pro-Ile-Val-Gln - ? 382945 3.4.23.16 Val-Ser-Gln-Ile-Tyr-Pro-Ile-Val-Gln + H2O - Human immunodeficiency virus 1 Val-Ser-Gln-Ile-Tyr + Pro-Ile-Val-Gln - ? 382946 3.4.23.16 Val-Ser-Gln-Leu-Tyr-Pro-Ile-Val-Gln + H2O - Human immunodeficiency virus 1 Val-Ser-Gln-Leu-Tyr + Pro-Ile-Val-Gln - ? 382947 3.4.23.16 Val-Ser-Gln-Phe-Tyr-Pro-Ile-Val-Gln + H2O - Human immunodeficiency virus 1 Val-Ser-Gln-Phe-Tyr + Pro-Ile-Val-Gln - ? 382948 3.4.23.16 Val-Ser-Gln-Thr-Tyr-Pro-Ile-Val-Gln + H2O - Human immunodeficiency virus 1 Val-Ser-Gln-Thr-Tyr + Pro-Ile-Val-Gln - ? 382949 3.4.23.16 Val-Ser-Gln-Val-Tyr-Pro-Ile-Val-Gln + H2O - Human immunodeficiency virus 1 Val-Ser-Gln-Val-Tyr + Pro-Ile-Val-Gln - ? 382950 3.4.23.16 VAQNYPIVQ + H2O - Human immunodeficiency virus 1 VAQNY + PIVQ - ? 363003 3.4.23.16 VDQNYPIVQ + H2O - Human immunodeficiency virus 1 VDQNY + PIVQ - ? 363002 3.4.23.16 VFQNYPIVQ + H2O - Human immunodeficiency virus 1 VFQNY + PIVQ - ? 363010 3.4.23.16 VGQNYPIVQ + H2O - Human immunodeficiency virus 1 VGQNY + PIVQ - ? 363000 3.4.23.16 VIQNYPIVQ + H2O - Human immunodeficiency virus 1 VIQNY + PIVQ - ? 362585 3.4.23.16 VKQNYPIVQ + H2O - Human immunodeficiency virus 1 VKQNY + PIVQ - ? 363007 3.4.23.16 VLQNYPIVQ + H2O - Human immunodeficiency virus 1 VLQNY + PIVQ - ? 359031 3.4.23.16 VLQNYPIVQ + H2O the protein contains a HIV-1 cleavage site Human immunodeficiency virus 1 VLQNY + PIVQ - ? 359031 3.4.23.16 VMQNYPIVQ + H2O - Human immunodeficiency virus 1 VMQNY + PIVQ - ? 363006 3.4.23.16 VNQNYPIVQ + H2O - Human immunodeficiency virus 1 VNQNY + PIVQ - ? 363001 3.4.23.16 VPQNYPIVQ + H2O - Human immunodeficiency virus 1 VPQNY + PIVQ - ? 362999 3.4.23.16 VRQNYPIVQ + H2O - Human immunodeficiency virus 1 VRQNY + PIVQ - ? 363004 3.4.23.16 VSFNFPQITKK + H2O - Human immunodeficiency virus 1 VSFNF + PQITKK - ? 362419 3.4.23.16 VSFNFPQITL + H2O - Human immunodeficiency virus 1 VSFNF + PQITL - ? 363131 3.4.23.16 VSQLYPIVQ + H2O the protein contains a HIV-1 cleavage site Human immunodeficiency virus 1 VSQLY + PIVQ - ? 359032 3.4.23.16 VSQNYPIDQ + H2O - Human immunodeficiency virus 1 VSQNY + PIDQ - ? 363054 3.4.23.16 VSQNYPIV + H2O - Human immunodeficiency virus 1 VSQNY + PIV - ? 362547 3.4.23.16 VSQNYPIVQ + H2O - Human immunodeficiency virus 1 VSQNY + PIVQ - ? 359030 3.4.23.16 VSQVYPIVQ + H2O the protein contains a HIV-1 cleavage site Human immunodeficiency virus 1 VSQVY + PIVQ - ? 362678 3.4.23.16 VTQNYPIVQ + H2O - Human immunodeficiency virus 1 VTQNY + PIVQ - ? 363005 3.4.23.16 VVQNYPIVQ + H2O - Human immunodeficiency virus 1 VVQNY + PIVQ - ? 363011 3.4.23.16 VVQNYPIVQ + H2O the protein contains a HIV-1 cleavage site Human immunodeficiency virus 1 VVQNY + PIVQ - ? 363011 3.4.23.16 YVSQNFPIVQNR + H2O synthetic peptide substrate based on the Ma/Ca cleavage site of HIV-1 Gag Human immunodeficiency virus 1 YVSQNF + PIVQNR - ? 382983