2.7.4.2	ADP + (R)-5-diphosphomevalonate	-	Homo sapiens	ATP + (R)-5-phosphomevalonate	-	r	399884	
2.7.4.2	ADPbetaS + 5-diphosphomevalonate	41fold slower kcat than with ADP	Streptococcus pneumoniae	ATPbetaS + 5-phosphomevalonate	-	r	359799	
2.7.4.2	ATP + (R)-5-phosphomevalonate	-	Saccharomyces cerevisiae	ADP + 5-diphosphomevalonate	-	?	370572	
2.7.4.2	ATP + (R)-5-phosphomevalonate	one of the enzymes in the biosynthetic pathway of the polyisoprenoid precursor isopentenyl diphosphate, enzyme has no regulatory function in cholesterol biosynthesis in liver	Sus scrofa	ADP + 5-diphosphomevalonate	-	r	370572	
2.7.4.2	ATP + (R)-5-phosphomevalonate	involved in isoprenoid biosynthesis pathway	Catharanthus roseus	ADP + 5-diphosphomevalonate	-	?	370572	
2.7.4.2	ATP + (R)-5-phosphomevalonate	enzyme of mevalonate pathway	Streptococcus pneumoniae	ADP + 5-diphosphomevalonate	-	r	370572	
2.7.4.2	ATP + (R)-5-phosphomevalonate	-	Homo sapiens	ADP + (R)-5-diphosphomevalonate	-	?	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	-	Homo sapiens	ADP + (R)-5-diphosphomevalonate	-	r	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	-	Sus scrofa	ADP + (R)-5-diphosphomevalonate	-	r	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	-	Streptococcus pneumoniae	ADP + (R)-5-diphosphomevalonate	-	?	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	-	Streptococcus pneumoniae	ADP + (R)-5-diphosphomevalonate	-	ir	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	-	Catharanthus roseus	ADP + (R)-5-diphosphomevalonate	-	?	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	-	Saccharolobus solfataricus	ADP + (R)-5-diphosphomevalonate	-	?	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	-	Saccharomyces cerevisiae	ADP + (R)-5-diphosphomevalonate	-	?	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	-	Cinnamomum camphora	ADP + (R)-5-diphosphomevalonate	-	r	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	-	Ginkgo biloba	ADP + (R)-5-diphosphomevalonate	-	?	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	mevalonate pathway of isopentenyl diphosphate biosynthesis	Homo sapiens	ADP + (R)-5-diphosphomevalonate	-	?	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	mevalonate pathway of isopentenyl diphosphate biosynthesis	Enterococcus faecalis	ADP + (R)-5-diphosphomevalonate	-	?	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	one of the initial steps in the biosynthesis of steroids and isoprenoids	Sus scrofa	ADP + (R)-5-diphosphomevalonate	-	r	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	active site structure and substrate binding coformation, detailed overview. Ligand binding reverses the side-chain orientations of two antiparallel lysines residues 100 and 101 with the result that Lys101 is switched into a position in which its ammonium ion is in direct contact with the beta,gamma-bridging atom of the nucleotide, where it is expected to stabilize both the ground and transition states of the reaction. The active site of PMK seems spacious enough to accommodate interconversion of the reactive and nonreactive conformers. A substantial fraction of the PMK active site is occupied by an active site water pentamer, which clusters near the charged regions of the substrate	Streptococcus pneumoniae	ADP + (R)-5-diphosphomevalonate	-	ir	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	PMK catalyzes the transfer of the gamma-phosphoryl group of ATP to (R)-5-phosphomevalonate, which results in the formation of ADP and (R)-5-diphosphomevalonate	Homo sapiens	ADP + (R)-5-diphosphomevalonate	-	?	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	the enzyme is involved in the classical mevalonate pathway	Saccharolobus solfataricus	ADP + (R)-5-diphosphomevalonate	-	?	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	-	Saccharolobus solfataricus P2	ADP + (R)-5-diphosphomevalonate	-	?	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	the enzyme is involved in the classical mevalonate pathway	Saccharolobus solfataricus P2	ADP + (R)-5-diphosphomevalonate	-	?	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	-	Saccharomyces cerevisiae ATCC 204508	ADP + (R)-5-diphosphomevalonate	-	?	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	mevalonate pathway of isopentenyl diphosphate biosynthesis	Enterococcus faecalis 41	ADP + (R)-5-diphosphomevalonate	-	?	378414	
2.7.4.2	ATP + (R)-5-phosphomevalonate	-	Catharanthus roseus C20A	ADP + (R)-5-diphosphomevalonate	-	?	378414	
2.7.4.2	ATP + (R)-mevalonate 5-phosphate	-	Homo sapiens	ADP + (R)-mevalonate 5-diphosphate	-	?	386238	
2.7.4.2	ATP + (R)-mevalonate 5-phosphate	-	Homo sapiens	ADP + (R)-mevalonate 5-diphosphate	-	r	386238	
2.7.4.2	ATP + (R)-mevalonate 5-phosphate	the enzyme catalyzes a key step in isoprenoid/sterol biosynthesis	Homo sapiens	ADP + (R)-mevalonate 5-diphosphate	-	r	386238	
2.7.4.2	ATP + (R,S)-5-phosphomevalonate	-	Enterococcus faecalis	ADP + (R,S)-5-diphosphomevalonate	-	?	379185	
2.7.4.2	ATP + (R,S)-5-phosphomevalonate	-	Enterococcus faecalis 41	ADP + (R,S)-5-diphosphomevalonate	-	?	379185	
2.7.4.2	ATP + 5-phosphomevalonate	-	Staphylococcus aureus	ADP + 5-diphosphomevalonate	-	?	359796	
2.7.4.2	ATP + 5-phosphomevalonate	-	Rattus norvegicus	ADP + 5-diphosphomevalonate	-	?	359796	
2.7.4.2	ATP + 5-phosphomevalonate	-	Sus scrofa	ADP + 5-diphosphomevalonate	-	?	359796	
2.7.4.2	ATP + 5-phosphomevalonate	-	Streptococcus pneumoniae	ADP + 5-diphosphomevalonate	-	?	359796	
2.7.4.2	ATP + 5-phosphomevalonate	-	Streptococcus pneumoniae	ADP + 5-diphosphomevalonate	-	r	359796	
2.7.4.2	ATP + 5-phosphomevalonate	-	Catharanthus roseus	ADP + 5-diphosphomevalonate	-	?	359796	
2.7.4.2	ATP + 5-phosphomevalonate	-	Homo sapiens	ADP + 5-diphosphomevalonate	-	?	359796	
2.7.4.2	ATP + 5-phosphomevalonate	(3R)-phosphomevalonate	Sus scrofa	ADP + 5-diphosphomevalonate	(3R)-diphosphomevalonate	r	359796	
2.7.4.2	ATP + 5-phosphomevalonate	absolute specificity for ATP	Sus scrofa	ADP + 5-diphosphomevalonate	-	?	359796	
2.7.4.2	ATP + 5-phosphomevalonate	absolute specificity for ATP	Sus scrofa	ADP + 5-diphosphomevalonate	(3R)-diphosphomevalonate	r	359796	
2.7.4.2	ATP + 5-phosphomevalonate	the equilibrium constant is near unity at pH 7.5 and 30°C	Sus scrofa	ADP + 5-diphosphomevalonate	(3R)-diphosphomevalonate	r	359796	
2.7.4.2	ATP + 5-phosphomevalonate	no activity with CTP and GTP	Hevea brasiliensis	ADP + 5-diphosphomevalonate	-	?	359796	
2.7.4.2	ATP + 5-phosphomevalonate	maximal activity at 10 mM ATP	Saccharomyces cerevisiae	ADP + 5-diphosphomevalonate	-	?	359796	
2.7.4.2	CTP + (R,S)-5-phosphomevalonate	0.4% activity	Enterococcus faecalis	CDP + (R,S)-5-diphosphomevalonate	-	?	379613	
2.7.4.2	CTP + (R,S)-5-phosphomevalonate	0.4% activity	Enterococcus faecalis 41	CDP + (R,S)-5-diphosphomevalonate	-	?	379613	
2.7.4.2	GTP + (R,S)-5-phosphomevalonate	3.6% activity	Enterococcus faecalis	GDP + (R,S)-5-diphosphomevalonate	-	?	379815	
2.7.4.2	GTP + (R,S)-5-phosphomevalonate	3.6% activity	Enterococcus faecalis 41	GDP + (R,S)-5-diphosphomevalonate	-	?	379815	
2.7.4.2	ITP + 5-phosphomevalonate	6% of activity with ATP	Hevea brasiliensis	IDP + 5-diphosphomevalonate	-	?	359798	
2.7.4.2	additional information	binding structure of AMPPNP, that interactswith both stationary and mobile regions of the PMK scaffold. The stationary region includes Ile65 and Leu66 as well as the glycine/serine-rich region, F102GLGSSGLV110, of motif II	Streptococcus pneumoniae	?	-	?	89	
2.7.4.2	additional information	the recombinant enzyme phosphorylates racemic vinyl, ethyl, n-propyl, n-butyl, i-butyl, 2-propenyl, allyl, ethynyl, and 1-propynyl mevalonate lactone analogues, that are phosphorylated by mevalonate kinase, EC 2.7.1.36, in a first step, overview	Streptococcus pneumoniae	?	-	?	89	
2.7.4.2	additional information	ATP binding structue analysis	Streptococcus pneumoniae	?	-	-	89	
2.7.4.2	TTP + (R,S)-5-phosphomevalonate	1.6% activity	Enterococcus faecalis	TDP + (R,S)-5-diphosphomevalonate	-	?	380366	
2.7.4.2	TTP + (R,S)-5-phosphomevalonate	1.6% activity	Enterococcus faecalis 41	TDP + (R,S)-5-diphosphomevalonate	-	?	380366	
2.7.4.2	UTP + 5-phosphomevalonate	13% of activity with ATP	Hevea brasiliensis	UDP + 5-diphosphomevalonate	-	?	359797