1.2.1.50 a long-chain acyl-CoA + NADPH + H+ - Cryptosporidium parvum a long-chain aldehyde + CoA + NADP+ - ? 425858 1.2.1.50 a long-chain fatty acyl-CoA + NADPH + H+ AmFAR1 converts saturated fatty acids ranging from 16 to 22 carbon chains to their corresponding alcohols with the highest conversion efficiency shown on 18:0, AmFAR1 also shows some activities on ricinoleic acid, 16:1n-7 and 18:1n-9 Apis mellifera a long-chain aldehyde + CoA + NADP+ aldehyde intermediate is immediately reduced to the corresponding alcohol ? 425859 1.2.1.50 arachidonoyl-CoA + NADPH + H+ - Marinobacter nauticus (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenal + CoA + NADP+ further reduction of (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenal into the corresponding (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-ol ? 425934 1.2.1.50 arachidoyl-CoA + NADP+ 29% of the activity with NADPH Acinetobacter sp. eicosanal + CoA + NADPH - ? 372425 1.2.1.50 arachidoyl-CoA + NADP+ 29% of the activity with NADPH Acinetobacter sp. M-1 eicosanal + CoA + NADPH - ? 372425 1.2.1.50 erucoyl-CoA + NADPH + H+ erucoyl-CoA i.e. (13Z)-docos-13-enoyl-CoA Marinobacter nauticus (13Z)-docos-13-enal + CoA + NADP+ further direct reduction of (13Z)-docos-13-enal into the corresponding (13Z)-docos-13-en-1-ol ? 426367 1.2.1.50 fatty acyl-CoA + NADPH + H+ - Marinobacter nauticus fatty aldehyde + CoA + NADP+ reaction intermediate, enzyme converts fatty acyl-CoA directly into the corresponding fatty alcohol by four-electron reduction, free fatty aldehyde intermediate is not accessible ? 426398 1.2.1.50 hexadecanoyl-CoA + NADPH + H+ - Pisum sativum hexadecanal + CoA + NADP+ - ? 189212 1.2.1.50 icosanoyl-CoA + NADPH + H+ - Marinobacter nauticus icosanal + CoA + NADP+ further direct reduction of icosanal into the corresponding icosan-1-ol ? 426505 1.2.1.50 lauroyl-CoA + NADP+ 33% of the activity with myristoyl-CoA Acinetobacter sp. dodecanal + CoA + NADPH - ? 373691 1.2.1.50 lauroyl-CoA + NADP+ 33% of the activity with myristoyl-CoA Acinetobacter sp. M-1 dodecanal + CoA + NADPH - ? 373691 1.2.1.50 lauroyl-CoA + NADPH + H+ - Marinobacter nauticus dodecanal + CoA + NADP+ further reduction of dodecanal into the corresponding dodecan-1-ol ? 426619 1.2.1.50 additional information substrates with carbon chain lengths shorter thah 8 do not show any activity Acinetobacter sp. ? - ? 89 1.2.1.50 additional information catalyses the formation of a fatty alcohol from an acyl-CoA Arabidopsis thaliana ? - ? 89 1.2.1.50 additional information enzyme only utilizes very long chain fatty acyl-CoAs as substrates, with activity on C26 > C24 > C22 > C20, but no activity on C18 and C16, enzyme is capable of using NADPH and NADH as electron donors, but prefers NADPH to NADH Cryptosporidium parvum ? - ? 89 1.2.1.50 additional information in contrast to other prokaryotes, the enzyme performs the two reduction steps from acyl-CoA to fatty alcohol in a single step which is typical for eukaryotes Marinobacter nauticus ? - ? 89 1.2.1.50 additional information no activity observed on 18:2n-6 and 18:3n-3 Apis mellifera ? - ? 89 1.2.1.50 additional information no reaction product detected with NADH or free fatty acids Marinobacter nauticus ? - ? 89 1.2.1.50 additional information shorter acyl chains than 16 carbon are less effectively utilized and with these substrates substantial amounts of both free fatty acids and fatty aldehyde are formed Marinobacter nauticus ? - ? 89 1.2.1.50 additional information substrates with carbon chain lengths shorter thah 8 do not show any activity Acinetobacter sp. M-1 ? - ? 89 1.2.1.50 myristoyl-CoA + NADP+ - Acinetobacter sp. ? + CoA + NADPH - ? 373859 1.2.1.50 myristoyl-CoA + NADP+ - Acinetobacter sp. M-1 ? + CoA + NADPH - ? 373859 1.2.1.50 myristoyl-CoA + NADPH - Photobacterium phosphoreum ? - ? 189261 1.2.1.50 myristoyl-CoA + NADPH + H+ - Marinobacter nauticus tetradecanal + CoA + NADP+ further reduction of tetradecanal into the corresponding tetradecan-1-ol ? 426705 1.2.1.50 octanoyl-CoA + NADPH + H+ - Marinobacter nauticus octanal + NADP+ further reduction of octanal into the corresponding octan-1-ol ? 426870 1.2.1.50 oleoyl-CoA + NADPH + H+ - Marinobacter nauticus (9Z)-octadec-9-enal + CoA + NADP+ further direct reduction of (9Z)-octadec-9-enal into the corresponding (9Z)-octadec-9-en-1-ol ? 426875 1.2.1.50 oleoyl-CoA + NADPH + H+ - Marinobacter nauticus (9Z)-octadec-9-enal + CoA + NADP+ further reduction of (9Z)-octadec-9-enal into the corresponding (9Z)-octadec-9-en-1-ol ? 426875 1.2.1.50 palmitoleoyl-CoA + NADPH + H+ - Marinobacter nauticus (9Z)-hexadec-9-enal + CoA + NADP+ further reduction of (9Z)-hexadec-9-enal into the corresponding (9Z)-hexadec-9-en-1-ol ? 426896 1.2.1.50 palmitoyl-ACP + NADPH the recombinant acyl-CoA reductase from Simmondsia chinensis exhibits a specificty to palmitoyl-ACP and not palmitoyl-CoA when expressed in Escherichia coli Simmondsia chinensis 1-hexadecanol + acyl-carrier protein + NADP+ - ? 389498 1.2.1.50 palmitoyl-CoA + NADP+ 90% of the activity with myristoyl-CoA Acinetobacter sp. hexadecanal + CoA + NADPH - ? 374268 1.2.1.50 palmitoyl-CoA + NADP+ 90% of the activity with myristoyl-CoA Acinetobacter sp. M-1 hexadecanal + CoA + NADPH - ? 374268 1.2.1.50 palmitoyl-CoA + NADPH + H+ - Anas platyrhynchos hexadecanal + CoA + NADP+ - r 426897 1.2.1.50 palmitoyl-CoA + NADPH + H+ - Marinobacter nauticus hexadecanal + CoA + NADP+ further direct reduction of hexadecanal into the corresponding hexadecan-1-ol ? 426897 1.2.1.50 palmitoyl-CoA + NADPH + H+ - Marinobacter nauticus hexadecanal + CoA + NADP+ further reduction of hexadecanal into the corresponding hexadecan-1-ol ? 426897 1.2.1.50 palmitoyl-[acyl-carrier protein] + NADPH + H+ - Marinobacter nauticus hexadecanal + [acyl-carrier protein] + NADP+ further direct reduction of hexadecanal into the corresponding hexadecan-1-ol ? 426898 1.2.1.50 ricinoleoyl-CoA + NADPH + H+ ricinoleoyl-CoA i.e. (9Z,12R)-12-hydroxyoctadec-9-enoyl-CoA Marinobacter nauticus (9Z,12R)-12-hydroxyoctadec-9-enal + CoA + NADP+ further direct reduction of (9Z,12R)-12-hydroxyoctadec-9-enal into the corresponding (9Z,12R)-octadec-9-ene-1,12-diol ? 427006 1.2.1.50 stearoyl-CoA + NADP+ 44% of the activity with myristoyl-CoA Acinetobacter sp. octadecanal + CoA + NADPH - ? 374655 1.2.1.50 stearoyl-CoA + NADPH + H+ - Marinobacter nauticus octadecanal + CoA + NADP+ further direct reduction of octadecanal into the corresponding octadecan-1-ol ? 427066 1.2.1.50 stearoyl-CoA + NADPH + H+ - Marinobacter nauticus octadecanal + CoA + NADP+ further reduction of octadecanal into the corresponding octadecan-1-ol ? 427066 1.2.1.50 tetradecanoyl-CoA + NADPH + H+ - Photobacterium phosphoreum tetradecanal + CoA + NADP+ - ? 189213 1.2.1.50 tetradecanoyl-CoA + NADPH + H+ - Photobacterium leiognathi tetradecanal + CoA + NADP+ - ? 189213 1.2.1.50 tetradecanoyl-CoA + NADPH + H+ - Acinetobacter sp. tetradecanal + CoA + NADP+ - ? 189213 1.2.1.50 tetraeicos-cis-15-enoyl-CoA + NADPH - Simmondsia chinensis tetraeicos-cis-15-en-1-ol + CoA + NADP+ - ? 189263