1.2.1.3 citral + NAD+ + H2O - Ipomoea batatas (2E)-3,7-dimethylocta-2,6-dienoic acid + NADH - ? 231512 1.2.1.3 (2E)-4-hydroxy-2-nonenal + NAD+ + H2O - Rattus norvegicus (2E)-4-hydroxy-2-nonenoic acid + NADH + H+ - ? 399143 1.2.1.3 (2E)-4-hydroxy-2-nonenal + NAD+ + H2O - Bos taurus (2E)-4-hydroxy-2-nonenoic acid + NADH + H+ - ? 399143 1.2.1.3 (R)-trans-4-hydroxy-2-nonenal + NAD+ + H2O - Rattus norvegicus (2E,4R)-4-hydroxynon-2-enoic acid + NADH + H+ - ? 399212 1.2.1.3 (R)-trans-4-hydroxy-2-nonenal + NAD+ + H2O ALDH5A enantioselectively oxidizes (R)-trans-4-hydroxy-2-nonenal Rattus norvegicus (2E,4R)-4-hydroxynon-2-enoic acid + NADH + H+ - ? 399212 1.2.1.3 (S)-trans-4-hydroxy-2-nonenal + NAD+ + H2O - Rattus norvegicus (2E,4S)-4-hydroxynon-2-enoic acid + NADH + H+ - ? 399238 1.2.1.3 trans-2-hexenal + NAD+ + H2O - Arabidopsis thaliana (E)-hex-2-enoate + NADH + H+ - ? 427128 1.2.1.3 (E)-2-nonenal + NAD+ + H2O - Arabidopsis thaliana (E)-non-2-enoate + NADH + H+ - ? 427130 1.2.1.3 2-nonenal + NAD+ + H2O - Homo sapiens (E)-non-2-enoate + NADH + H+ - ? 413968 1.2.1.3 trans-2-nonenal + NAD+ + H2O - Arabidopsis thaliana (E)-non-2-enoate + NADH + H+ - ? 439942 1.2.1.3 glyceryl trinitrate + NADH + H+ - Homo sapiens 1,2-glyceryl dinitrate + nitrite + NAD+ - ? 405314 1.2.1.3 nitroglycerin + NAD+ + H2O - Homo sapiens 1,2-glyceryl dinitrate + NO + NADH + H+ - ? 415054 1.2.1.3 glyceryl trinitrate + NADH + H+ - Homo sapiens 1,3-glyceryl dinitrate + nitrite + NAD+ - ? 405315 1.2.1.3 1-naphthaldehyde + NAD+ + H2O 46.9% activity compared to p-tolualdehyde Sphingomonas sp. 1-naphthoic acid + NADH - ? 387018 1.2.1.3 1-naphthaldehyde + NAD+ + H2O - Homo sapiens 1-naphthoic acid + NADH + H+ - ? 403259 1.2.1.3 2,4-dinitrobenzaldehyde + NAD+ + H2O - Homo sapiens 2,4-dinitrobenzoate + NADH - ? 231548 1.2.1.3 2-chlorobenzaldehyde + NAD+ + H2O 28.35% activity compared to formaldehyde Geobacillus thermodenitrificans 2-chlorobenzoate + NADH + H+ - ? 231670 1.2.1.3 2-furaldehyde + NAD+ + H2O - Escherichia coli 2-furanoic acid + NADH + H+ - ? 399429 1.2.1.3 2-furaldehyde + NAD+ + H2O the activity on 2-furaldehyde is 22% of that on 3-hydroxypropionaldehyde Klebsiella pneumoniae 2-furanoic acid + NADH + H+ - ? 399429 1.2.1.3 2-hydroxy-3-nitrobenzaldehyde + NAD+ + H2O - Homo sapiens 2-hydroxy-3-nitrobenzoic acid + NADH + H+ - ? 399435 1.2.1.3 2-naphthaldehyde + NAD+ + H2O - Homo sapiens 2-naphthalene carboxylate + NADH + H+ - ? 403592 1.2.1.3 2-naphthaldehyde + NAD+ + H2O - Homo sapiens 2-naphthoate + NADH - ? 231562 1.2.1.3 2-naphthaldehyde + NAD+ + H2O 48.8% activity compared to p-tolualdehyde Sphingomonas sp. 2-naphthoic acid + NADH - ? 387192 1.2.1.3 2-naphthaldehyde + NAD+ + H2O - Homo sapiens 2-naphthoic acid + NADH + H+ - ? 403593 1.2.1.3 2-quinolinone-4-carboxaldehyde + NAD+ + H2O - Homo sapiens 2-quinolinone-4-carboxylate + NADH - ? 231572 1.2.1.3 3,4,5-trimethoxybenzaldehyde + NAD+ + H2O - Phanerodontia chrysosporium 3,4,5-trimethoxybenzoic acid + NADH + H+ - ? 414000 1.2.1.3 3,4-dihydroxybenzaldehyde + NAD+ + H2O - Phanerodontia chrysosporium 3,4-dihydroxybenzoic acid + NADH + H+ - ? 414006 1.2.1.3 3,4-dihydroxymandelic aldehyde + NAD+ + H2O - Rattus norvegicus 3,4-dihydroxymandelate + NADH - ? 231590 1.2.1.3 3,4-dihydroxyphenyl acetaldehyde + NAD+ + H2O - Rattus norvegicus 3,4-dihydroxyphenylacetate + NADH - ? 231591 1.2.1.3 3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O - Homo sapiens 3,4-dihydroxyphenylacetate + NADH + H+ - ? 231527 1.2.1.3 3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O - Rattus norvegicus 3,4-dihydroxyphenylacetate + NADH + H+ - ? 231527 1.2.1.3 3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O - Ovis aries 3,4-dihydroxyphenylacetate + NADH + H+ - ? 231527 1.2.1.3 3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O - Rattus norvegicus 3,4-dihydroxyphenylacetic acid + NADH + H+ - ? 438102 1.2.1.3 3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O - Homo sapiens 3,4-dihydroxyphenylglycolate + NADH + H+ - ? 395687 1.2.1.3 3,4-dimethoxy-5-hydroxybenzaldehyde + NAD+ + H2O - Phanerodontia chrysosporium 3,4-dimethoxy-5-hydroxybenzoic acid + NADH + H+ - ? 414008 1.2.1.3 3,4-dimethoxybenzaldehyde + NAD+ + H2O - Homo sapiens 3,4-dimethoxybenzoate + NADH - ? 231558 1.2.1.3 3,4-dimethoxybenzaldehyde + NAD+ + H2O - Phanerodontia chrysosporium 3,4-dimethoxybenzoic acid + NADH + H+ - ? 414009 1.2.1.3 3-hydroxy-4-methoxybenzaldehyde + NAD+ + H2O - Cavia porcellus 3-hydroxy-4-methoxybenzoate + NADH + H+ - ? 387363 1.2.1.3 3-hydroxypropionaldehyde + NAD+ + H2O - Escherichia coli 3-hydroxypropanoate + NADH + 2 H+ - r 399543 1.2.1.3 3-hydroxypropionaldehyde + NAD+ + H2O the activity on 3-hydroxypropionaldehyde is about 70% of that on valeraldehyde Klebsiella pneumoniae 3-hydroxypropanoate + NADH + 2 H+ - ? 399543 1.2.1.3 3-hydroxypropanoate + NADH + 2 H+ - Escherichia coli 3-hydroxypropionaldehyde + NAD+ + H2O - r 399544 1.2.1.3 3-hydroxypropaldehyde + NAD+ + H2O - Klebsiella pneumoniae 3-hydroxypropionate + NADH + H+ - ? 425556 1.2.1.3 3-hydroxypropanal + NAD+ + H2O - Klebsiella pneumoniae 3-hydroxypropionate + NADH + H+ - ? 444705 1.2.1.3 3-hydroxypropanal + NAD+ + H2O - Klebsiella pneumoniae DSM 2026 3-hydroxypropionate + NADH + H+ - ? 444705 1.2.1.3 3-hydroxypropionaldehyde + NAD+ + H2O - Escherichia coli 3-hydroxypropionic acid + NADH + H+ - ? 438787 1.2.1.3 3-hydroxypropionaldehyde + NAD+ + H2O - Klebsiella pneumoniae 3-hydroxypropionic acid + NADH + H+ - ? 438787 1.2.1.3 3-hydroxypropionaldehyde + NAD+ + H2O - Klebsiella pneumoniae subsp. pneumoniae 3-hydroxypropionic acid + NADH + H+ - ? 438787 1.2.1.3 3-hydroxypropionaldehyde + NAD+ + H2O specific substrate Klebsiella pneumoniae 3-hydroxypropionic acid + NADH + H+ - ? 438787 1.2.1.3 3-hydroxypropionaldehyde + NAD+ + H2O - Klebsiella pneumoniae subsp. pneumoniae ATCC 700721 3-hydroxypropionic acid + NADH + H+ - ? 438787 1.2.1.3 3-hydroxypropionaldehyde + NAD+ + H2O specific substrate Klebsiella pneumoniae MCG 78578 3-hydroxypropionic acid + NADH + H+ - ? 438787 1.2.1.3 3-methoxy-4-hydroxyphenylacetaldehyde + NAD+ + H2O - Ovis aries 3-methoxy-4-hydroxyphenylacetate + NADH + H+ - ? 231583 1.2.1.3 3-nitrobenzaldehyde + NAD+ + H2O 32.98% activity compared to acetaldehyde Sulfurisphaera tokodaii 3-nitrobenzoate + NADH + H+ - ? 403760 1.2.1.3 3-pyridinecarboxaldehyde + NAD+ + H2O - Homo sapiens 3-pyridinecarboxylate + NADH - ? 231580 1.2.1.3 4-aminobutyraldehyde + NAD+ + H2O - Homo sapiens 4-aminobutyrate + NADH - ? 231537 1.2.1.3 4-carboxybenzaldehyde + NAD+ + H2O - Rattus norvegicus 4-carboxybenzoate + NADH - ? 231564 1.2.1.3 4-chlorobenzaldehyde + NAD+ + H2O - Rattus norvegicus 4-chlorobenzoate + NADH - ? 231520 1.2.1.3 4-chlorophenylacetaldehyde + NAD+ + H2O - Escherichia coli 4-chlorophenylacetate + NADH + H+ - ? 438834 1.2.1.3 4-cyanobenzaldehyde + NAD+ + H2O - Rattus norvegicus 4-cyanobenzoate + NADH - ? 231509 1.2.1.3 4-dimethylamino-1-naphthaldehyde + NAD+ + H2O - Homo sapiens 4-dimethylamino-1-naphthoic acid + NADH + H+ - ? 403823 1.2.1.3 4-dimethylaminobenzaldehyde + NAD+ + H2O - Homo sapiens 4-dimethylaminobenzoate + NADH + H+ - ? 403824 1.2.1.3 4-fluorophenylacetaldehyde + NAD+ + H2O - Escherichia coli 4-fluorophenylacetate + NADH + H+ - ? 438840 1.2.1.3 4-hydroxy-2-nonenal + NAD+ + H2O - Mus musculus 4-hydroxy-2-nonenoate + NADH + H+ - ? 399653 1.2.1.3 4-hydroxy-2-nonenal + NAD+ + H2O low affinity for substrate binding and poor catalytic efficiency Homo sapiens 4-hydroxy-2-nonenoate + NADH + H+ - ? 399653 1.2.1.3 4-hydroxy-3,5-dimethoxybenzaldehyde + NAD+ + H2O - Phanerodontia chrysosporium 4-hydroxy-3,5-dimethoxybenzoic acid + NADH + H+ - ? 414108 1.2.1.3 4-hydroxy-3-methoxybenzaldehyde + NAD+ + H2O - Homo sapiens 4-hydroxy-3-methoxybenzoate + NADH + H+ - ? 139573 1.2.1.3 4-hydroxy-3-methoxybenzaldehyde + NAD+ + H2O - Phanerodontia chrysosporium 4-hydroxy-3-methoxybenzoic acid + NADH + H+ - ? 414109 1.2.1.3 4-hydroxybenzaldehyde + NAD+ + H2O - Phanerodontia chrysosporium 4-hydroxybenzoic acid + NADH + H+ - ? 414110 1.2.1.3 4-hydroxy-2-nonenal + NAD+ + H2O - Oryctolagus cuniculus 4-hydroxynon-2-enoate + NADH + H+ - ? 413220 1.2.1.3 4-hydroxy-2-nonenal + NAD+ + H2O - Mus musculus 4-hydroxynon-2-enoic acid + NADH - ? 413221 1.2.1.3 4-hydroxy-2-nonenal + NAD+ + H2O poor substrate of isoform ALDH3A1 Mus musculus 4-hydroxynon-2-enoic acid + NADH - ? 413221 1.2.1.3 4-hydroxynon-2-enal + NAD+ - Homo sapiens 4-hydroxynon-2-enoic acid + NADH - ? 387475 1.2.1.3 4-hydroxynonenal + NAD+ + H2O - Oryctolagus cuniculus 4-hydroxynonanoate + NADH - ? 371960 1.2.1.3 4-hydroxynonenal + NAD+ + H2O - Homo sapiens 4-hydroxynonanoate + NADH + H+ - ? 371961 1.2.1.3 4-hydroxyphenyl-3-methoxyglycolaldehyde + NAD+ + H2O - Sus scrofa 4-hydroxyphenyl-3-methoxyglycolate + NADH - ? 231531 1.2.1.3 4-hydroxyphenylglycolaldehyde + NAD+ + H2O - Sus scrofa 4-hydroxyphenylglycolate + NADH - ? 231530 1.2.1.3 4-methoxy-1-naphthaldehyde + NAD+ + H2O - Homo sapiens 4-methoxy-1-naphthoate + NADH - ? 231563 1.2.1.3 4-methoxy-1-naphthaldehyde + NAD+ + H2O - Homo sapiens 4-methoxy-1-naphthoic acid + NADH + H+ - ? 403870 1.2.1.3 4-methoxybenzaldehyde + NAD+ + H2O - Homo sapiens 4-methoxybenzoate + NADH + H+ - ? 258061 1.2.1.3 4-nitro-1-naphthaldehyde + NAD+ + H2O - Homo sapiens 4-nitro-1-naphthoate + NADH - ? 231560 1.2.1.3 4-nitrophenyl acetate + H2O - Bos taurus 4-nitrophenol + acetate - r 12514 1.2.1.3 4-oxonon-2-enal + NAD+ + H2O - Homo sapiens 4-oxonon-2-enoic acid + NADH - ? 387540 1.2.1.3 5-(dimethylamino)-2-naphthaldehyde + NAD+ + H2O - Homo sapiens 5-(dimethylamino)-2-naphthoate + NADH + H+ - r 451444 1.2.1.3 5-bromo-1-naphthaldehyde + NAD+ + H2O - Homo sapiens 5-bromo-1-naphthoate + NADH - ? 231559 1.2.1.3 5-hydroxyindol acetaldehyde + NAD+ + H2O - Rattus norvegicus 5-hydroxyindol acetate + NADH + H+ - ? 231592 1.2.1.3 5-methoxyindole-3-carboxaldehyde + NAD+ + H2O - Homo sapiens 5-methoxyindole-3-carboxylate + NADH - ? 231579 1.2.1.3 5-nitro-1-naphthaldehyde + NAD+ + H2O - Homo sapiens 5-nitro-1-naphthoate + NADH + H+ - r 451445 1.2.1.3 6,7-dimethoxycoumarin-3-carboxaldehyde + NAD+ + H2O - Homo sapiens 6,7-dimethoxycoumarin-3-carboxylate + NADH + H+ - r 451446 1.2.1.3 6,7-dimethoxycoumarin-4-carboxaldehyde + NAD+ + H2O - Homo sapiens 6,7-dimethoxycoumarin-4-carboxylate + NADH - ? 231568 1.2.1.3 6-(dimethylamino)-2-naphthaldehyde + NAD+ + H2O - Homo sapiens 6-(dimethylamino)-2-naphthoate + NADH - ? 231561 1.2.1.3 6-dimethylamino-2-naphthaldehyde + NAD+ + H2O activity assay Homo sapiens 6-dimethylamino-2-naphthalene carboxylate + NADH + H+ - ? 404063 1.2.1.3 6-dimethylamino-2-naphthaldehyde + NAD+ + H2O - Homo sapiens 6-dimethylamino-2-naphthoic acid + NADH + H+ - ? 404064 1.2.1.3 6-methoxy-2-naphthaldehyde + NAD+ + H2O activity assay Homo sapiens 6-methoxy-2-naphthalene carboxylate + NADH + H+ - ? 404068 1.2.1.3 6-methoxy-2-naphthaldehyde + NAD+ + H2O - Homo sapiens 6-methoxy-2-naphthoate + NADH + H+ - ? 399763 1.2.1.3 6-methoxy-2-naphthaldehyde + NAD+ + H2O activity assay Homo sapiens 6-methoxy-2-naphthoate + NADH + H+ - ? 399763 1.2.1.3 6-methoxy-2-naphthaldehyde + NAD+ + H2O - Homo sapiens 6-methoxy-2-naphthoic acid + NADH + H+ - ? 404069 1.2.1.3 6-methoxy-2-quinolinone-4-carboxaldehyde + NAD+ + H2O - Homo sapiens 6-methoxy-2-quinolinone-4-carboxylate + NADH - ? 231574 1.2.1.3 1-formyl-6-methylpyrene + NAD+ - Homo sapiens 6-methylpyrene 1-carboxylate + NADH + H+ - ? 395244 1.2.1.3 1-formyl-6-methylpyrene + NAD+ + H2O - Homo sapiens 6-methylpyrene-1-carboxylic acid + NADH + H+ - ? 399268 1.2.1.3 7-(dimethylamino)-2-quinolinone-4-carboxaldehyde + NAD+ + H2O - Homo sapiens 7-(dimethylamino)-2-quinolinone-4-carboxylate + NADH - ? 231573 1.2.1.3 7-(dimethylamino)-coumarin-3-carboxaldehyde + NAD+ + H2O - Homo sapiens 7-(dimethylamino)-coumarin-3-carboxylate + NADH + H+ - r 451447 1.2.1.3 7-(dimethylamino)coumarin-4-carboxaldehyde + NAD+ + H2O - Homo sapiens 7-(dimethylamino)coumarin-4-carboxylate + NADH - ? 231566 1.2.1.3 7-acetoxycoumarin-3-carboxaldehyde + NAD+ + H2O - Homo sapiens 7-acetoxycoumarin-3-carboxylate + NADH + H+ - r 451448 1.2.1.3 7-acetoxycoumarin-4-carboxaldehyde + NAD+ + H2O - Homo sapiens 7-acetoxycoumarin-4-carboxylate + NADH - ? 231565 1.2.1.3 7-hydroxycoumarin-3-carboxaldehyde + NAD+ + H2O - Homo sapiens 7-hydroxycoumarin-3-carboxylate + NADH + H+ - r 451449 1.2.1.3 7-hydroxycoumarin-4-carboxaldehyde + NAD+ + H2O - Homo sapiens 7-hydroxycoumarin-4-carboxylate + NADH - ? 231569 1.2.1.3 7-methoxy-1-naphthaldehyde + NAD+ + H2O - Homo sapiens 7-methoxy-1-naphthoic acid + NADH + H+ - ? 399777 1.2.1.3 7-methoxy-1-naphthaldehyde + NAD+ + H2O - Rattus norvegicus 7-methoxy-1-naphthoic acid + NADH + H+ - ? 399777 1.2.1.3 7-methoxy-1-naphthaldehyde + NAD+ + H2O - Bos taurus 7-methoxy-1-naphthoic acid + NADH + H+ - ? 399777 1.2.1.3 7-methoxy-2-quinolinone-4-carboxaldehyde + NAD+ + H2O - Homo sapiens 7-methoxy-2-quinolinone-4-carboxylate + NADH - ? 231575 1.2.1.3 7-methoxycoumarin-3-carboxaldehyde + NAD+ + H2O - Homo sapiens 7-methoxycoumarin-3-carboxylate + NADH + H+ - r 451450 1.2.1.3 7-methoxycoumarin-4-carboxaldehyde + NAD+ + H2O - Homo sapiens 7-methoxycoumarin-4-carboxylate + NADH - ? 231567 1.2.1.3 1-formyl-8-methylpyrene + NADP+ - Homo sapiens 8-methylpyrene 1-carboxylate + NADPH + H+ - ? 395247 1.2.1.3 1-formyl-8-methylpyrene + NAD+ + H2O - Homo sapiens 8-methylpyrene-1-carboxylic acid + NADH + H+ - ? 399269 1.2.1.3 9-cis retinal + NAD+ + H2O - Homo sapiens 9-cis retinoic acid + NADH - ? 399795 1.2.1.3 9-cis-retinal + NAD+ + H2O - Homo sapiens 9-cis-retinoic acid + NADH + H+ - ? 399796 1.2.1.3 (R)-N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b] thiophene-2-carboxamide + H2O + O2 i.e. GDC-0834, a Bruton's tyrosine kinase inhibitor, a potential treatment of rheumatoid arthritis. GDC-0834 Homo sapiens ? compound is extensively metabolized by amide hydrolysis by both aldehyde oxidase and carboxylesterase ? 438562 1.2.1.3 3-oxopropyl phosphonate + NAD+ + H2O - Sinorhizobium meliloti ? - ? 440806 1.2.1.3 3-oxopropylphosphonate + NAD+ + H2O - Sinorhizobium meliloti ? - ? 429730 1.2.1.3 glyceraldehyde 3-phosphate + NAD+ + H2O - Sinorhizobium meliloti ? - ? 441422 1.2.1.3 glyceraldehyde-3-phosphate + NAD+ + H2O - Sinorhizobium meliloti ? - ? 430230 1.2.1.3 malondialdehyde + NAD+ + H2O - Mus musculus ? - ? 413456 1.2.1.3 malondialdehyde + NAD+ + H2O - Oryza sativa ? - ? 413456 1.2.1.3 malondialdehyde + NAD+ + H2O poor substrate of isoform ALDH3A1 Oryctolagus cuniculus ? - ? 413456 1.2.1.3 malondialdehyde + NAD+ + H2O low affinity for substrate binding and poor catalytic efficiency Homo sapiens ? - ? 413456 1.2.1.3 additional information - Ovis aries ? - ? 89 1.2.1.3 additional information no activity with NADP+ Arabidopsis thaliana ? - ? 89 1.2.1.3 additional information enzyme also posseses esterase activity Ctenopharyngodon idella ? - ? 89 1.2.1.3 additional information the enzyme also catalyzes esterase reaction with p-nitrophenylacetate + H2O Bos taurus ? - ? 89 1.2.1.3 additional information the enzyme also catalyzes esterase reaction with p-nitrophenylacetate + H2O Ovis aries ? - ? 89 1.2.1.3 additional information enzyme also catalyzes esterase reaction with p-nitrophenyl pivalate + H2O Ovis aries ? - ? 89 1.2.1.3 additional information constitutive enzyme Pseudomonas aeruginosa ? - ? 89 1.2.1.3 additional information enzyme ALD2 and ALD3 are stress-induced and glucose-repressed Saccharomyces cerevisiae ? - ? 89 1.2.1.3 additional information the microsomal membrane-bound enzyme is expected to catalyze the oxidation of such water-insoluble aldehydes produced on the surface of the microsomal membrane. The enzyme may also be involved in the conversion of fatty acids to alpha,omega-dicarboxylic acids Rattus norvegicus ? - ? 89 1.2.1.3 additional information the enzyme may play a role in insecticide resistance Culex quinquefasciatus ? - ? 89 1.2.1.3 additional information the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation Homo sapiens ? - ? 89 1.2.1.3 additional information the enzyme may contribute to corneal cellular defense against oxidative damage by metabolizing toxic aldehydes produced during UV-induced lipid peroxidation Oryctolagus cuniculus ? - ? 89 1.2.1.3 additional information the majority of the vascular ALDH2 is present in the cytoplasm, suggesting that mitochondrial biotransformation of glyceryl trinitrate by ALDH2 plays a minor role in the overall vascular biotransformation Rattus norvegicus ? - ? 89 1.2.1.3 additional information no activity with benzaldehyde Acanthopagrus schlegelii ? - ? 89 1.2.1.3 additional information the enzyme is only marginally active with acetaldehyde, while longer-chain aliphatic aldehydes are poor substrates Pseudomonas putida ? - ? 89 1.2.1.3 additional information no activity with formaldehyde Homo sapiens ? - ? 89 1.2.1.3 additional information no activity towards 3-hydroxypropionic acid in the presence of NADPH and formaldehyde Escherichia coli ? - ? 89 1.2.1.3 additional information Aldh3a1 metabolizes toxic aldehydes produced by light-induced lipid peroxidation Mus musculus ? - ? 89 1.2.1.3 additional information involved in detoxication of a variety of aldehydes of plant origin, as well as those formed during food processing, or applied as food additives Homo sapiens ? - ? 89 1.2.1.3 additional information ALDH2 is a direct downstream substrate of epsilon protein kinase C Homo sapiens ? - ? 89 1.2.1.3 additional information ALDH2 denitrates nitroglycerin to 1,2-glyceryl dinitrate and nitrite but also catalyzes reduction of nitroglycerin to NO. In addition to aldehyde oxidation, ALDH2 catalyzes ester hydrolysis. The esterase activity is stimulated by NAD+, but the cofactor is not essential for the reaction Homo sapiens ? - ? 89 1.2.1.3 additional information no activity is detected when NADP+ is used as the oxidant instead of NAD+ Sphingopyxis macrogoltabida ? - ? 89 1.2.1.3 additional information no activity towards NADP+, tetracosaldehyde, 2-hydroxylbenzaldehyde, ethanol, hexadecanol, acetate, and hexadecanoic acid Geobacillus thermodenitrificans ? - ? 89 1.2.1.3 additional information no activity with NADP+ and unsaturated aldehydes like trans-2-hexenal, trans-2-nonenal, and trans-2 dodecenal Homo sapiens ? - ? 89 1.2.1.3 additional information no appreciable activity is observed on formaldehyde Klebsiella pneumoniae ? - ? 89 1.2.1.3 additional information the ALDH has no reductive activity on acetate or hexadecanoic acid Geobacillus thermodenitrificans ? - ? 89 1.2.1.3 additional information the enzyme shows esterase activity with 4-nitrophenyl acetate Homo sapiens ? - ? 89 1.2.1.3 additional information no activity with aromatic aldehydes such as benzaldehyde, nitrobenzaldehyde, methoxybenzaldehyde, or phenylacetaldehyde Homo sapiens ? - ? 89 1.2.1.3 additional information no activity with methanol, ethanol and isopropanol Sulfurisphaera tokodaii ? - ? 89 1.2.1.3 additional information no activity with NADP+. Saturated aldehydes are preferred over unsaturated aldehydes, irrespective of chain length Arabidopsis thaliana ? - ? 89 1.2.1.3 additional information no activity with propionaldehyde, butyraldehyde, valeraldehyde, isovaleraldehyde, and furaldehyde Klebsiella pneumoniae ? - ? 89 1.2.1.3 additional information the enzyme shows 11% activity with NADP+ compared to NAD+. No activity with phenazine methosulfate Escherichia coli ? - ? 89 1.2.1.3 additional information enzyme LsALDH16 also exhibits esterase activity with 4-nitrophenylacetate (pNPA) as substrate in the absence of NAD+, kinetics, overview Loktanella sp. ? - - 89 1.2.1.3 additional information no activity with hexanal, propanal, nonanal, acetaldehyde and aminoadipate semialdehyde Homo sapiens ? - - 89 1.2.1.3 additional information to assess the degree of formaldehyde degradation, luminescence measurements in Vibrio fischeri for formaldehyde toxicity are conducted Saccharomyces cerevisiae ? - - 89 1.2.1.3 additional information no activity with propionaldehyde, butyraldehyde, valeraldehyde, isovaleraldehyde, and furaldehyde Klebsiella pneumoniae MCG 78578 ? - ? 89 1.2.1.3 additional information no appreciable activity is observed on formaldehyde Klebsiella pneumoniae DSM 2026 ? - ? 89 1.2.1.3 additional information no activity with methanol, ethanol and isopropanol Sulfurisphaera tokodaii 7 ? - ? 89 1.2.1.3 additional information to assess the degree of formaldehyde degradation, luminescence measurements in Vibrio fischeri for formaldehyde toxicity are conducted Saccharomyces cerevisiae ATCC 204508 ? - - 89 1.2.1.3 additional information no activity towards NADP+, tetracosaldehyde, 2-hydroxylbenzaldehyde, ethanol, hexadecanol, acetate, and hexadecanoic acid Geobacillus thermodenitrificans NG80-2 ? - ? 89 1.2.1.3 additional information the ALDH has no reductive activity on acetate or hexadecanoic acid Geobacillus thermodenitrificans NG80-2 ? - ? 89 1.2.1.3 additional information no activity is detected when NADP+ is used as the oxidant instead of NAD+ Sphingopyxis macrogoltabida TFA ? - ? 89 1.2.1.3 phosphonoacetaldehyde + NAD+ - Sinorhizobium meliloti ? - ? 429363 1.2.1.3 pimelic semialdehyde + NAD+ + H2O - Sphingopyxis macrogoltabida ? - ? 415133 1.2.1.3 pimelic semialdehyde + NAD+ + H2O - Sphingopyxis macrogoltabida TFA ? - ? 415133 1.2.1.3 anisaldehyde + NAD+ + H2O - Rattus norvegicus ? + NADH - ? 231514 1.2.1.3 malondialdehyde + NAD+ + H2O - Homo sapiens ? + NADH - ? 231535 1.2.1.3 malondialdehyde + NAD+ + H2O - Bos taurus ? + NADH - ? 231535 1.2.1.3 malondialdehyde + NAD+ + H2O - Oryctolagus cuniculus ? + NADH - ? 231535 1.2.1.3 1,3-dihydroxyacetone + NAD+ + H2O 53.93% activity compared to acetaldehyde Sulfurisphaera tokodaii ? + NADH + H+ - ? 422249 1.2.1.3 4-hydroxynonenal + NAD+ + H2O - Arabidopsis thaliana ? + NADH + H+ - ? 425669 1.2.1.3 acrolein + NAD+ + H2O - Homo sapiens ? + NADH + H+ - ? 425892 1.2.1.3 aldophosphamide + NAD+ + H2O - Homo sapiens ? + NADH + H+ - ? 399895 1.2.1.3 malondialdehyde + NAD+ + H2O - Homo sapiens ? + NADH + H+ - ? 426629 1.2.1.3 acetate + NADH + H+ - Thermoanaerobacterium saccharolyticum acetaldehyde + NAD+ + H2O - ? 439005 1.2.1.3 acetate + NADH + H+ - Acetivibrio thermocellus acetaldehyde + NAD+ + H2O - ? 439005 1.2.1.3 acetate + NADH + H+ - Acetivibrio thermocellus DSM 1313 acetaldehyde + NAD+ + H2O - ? 439005 1.2.1.3 acetate + NADH + H+ - Thermoanaerobacterium saccharolyticum JW/SL-YS485 acetaldehyde + NAD+ + H2O - ? 439005 1.2.1.3 acetaldehyde + NAD+ + H2O - Mus musculus acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Escherichia coli acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Homo sapiens acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Homo sapiens acetate + NADH + H+ - ir 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Rattus norvegicus acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Sus scrofa acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Saccharomyces cerevisiae acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Bos taurus acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Euglena gracilis acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Ovis aries acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Ovis aries acetate + NADH + H+ - ir 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Arabidopsis thaliana acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Pseudomonas aeruginosa acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Bacillus cereus acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Nocardia sp. acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Equus caballus acetate + NADH + H+ - ir 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Thermoanaerobacterium saccharolyticum acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Oryzias latipes acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Ipomoea batatas acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Acanthopagrus schlegelii acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Danio rerio acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Acetivibrio thermocellus acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Culex quinquefasciatus acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Ctenopharyngodon idella acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Oryza sativa acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Natronomonas pharaonis acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Lachnoclostridium phytofermentans acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O preferred substrate Homo sapiens acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O activity with cytosolic enzyme, no activity with microsomal enzyme Oryctolagus cuniculus acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O mutations in Aldh2 strongly segregate with the phenotypes of low and high alcohol consumption and with kinetic differences in ALDH2, suggesting that pharmacogenetic differences affect voluntary alcohol consumption. Bases mutated in the coding region suggest that aldh2(2) in low drinkers is ancestral to the coding changes of either aldh2(1) or aldh2(3), which segregate with higher ethanol consumption Rattus norvegicus acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O activity assay Homo sapiens acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O activity assay Saccharomyces cerevisiae acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O rats with an mutated allele for aldehyde dehydrogenase (ALDH2-2) show a low alcohol consumption phenotype. Homozygous ALDH2-2 rats derived from high-drinker F0 females showed a remarkly higher ethanol consumption than homozygous animals derived from low-drinker females. Mitochondria of F2 rats derived from high alcohol-consuming females were more active in oxidizing substrates that generate NADH for complex I Rattus norvegicus acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O preferred substrate of isozyme ALDH2 Homo sapiens acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O 77.68% activity compared to formaldehyde Geobacillus thermodenitrificans acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O the activity on acetaldehyde is about 50% of that on valeraldehyde Klebsiella pneumoniae acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O 100% activity with acetaldehyde and NAD+ Sulfurisphaera tokodaii acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Nocardia sp. 239 acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O the activity on acetaldehyde is about 50% of that on valeraldehyde Klebsiella pneumoniae DSM 2026 acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Acetivibrio thermocellus DSM 1313 acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O 100% activity with acetaldehyde and NAD+ Sulfurisphaera tokodaii 7 acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Pseudomonas aeruginosa IH 35342 acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Bacillus cereus ATCC 10876 acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O - Thermoanaerobacterium saccharolyticum JW/SL-YS485 acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NAD+ + H2O 77.68% activity compared to formaldehyde Geobacillus thermodenitrificans NG80-2 acetate + NADH + H+ - ? 189125 1.2.1.3 acetaldehyde + NADP+ + H2O low activity with NADP+ Sulfurisphaera tokodaii acetate + NADPH + H+ - ? 231682 1.2.1.3 all-trans retinal + NAD+ + H2O - Homo sapiens all-trans retinoic acid + NADH - ? 399898 1.2.1.3 all-trans-retinal + NAD+ + H2O - Homo sapiens all-trans-retinoic acid + NADH + H+ - ? 399906 1.2.1.3 alpha-aminoadipate semialdehyde + NAD+ + H2O - Homo sapiens alpha-aminoadipate + NADH + H+ - ? 438184 1.2.1.3 alpha-aminoadipate semialdehyde + NAD+ + H2O - Homo sapiens alpha-aminoadipic acid + NADH + H+ - ? 414270 1.2.1.3 alpha-phenylpropanal + NAD+ + H2O - Homo sapiens alpha-phenylpropionate + NADH - ? 231547 1.2.1.3 an aldehyde + NAD+ + H2O - Homo sapiens an acid + NADH + H+ - ? 402424 1.2.1.3 benzaldehyde + NAD(P)+ + H2O - Pseudomonas putida benzoate + NAD(P)H + H+ - ? 391413 1.2.1.3 benzaldehyde + NAD+ + H2O - Homo sapiens benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O - Rattus norvegicus benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O - Euglena gracilis benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O - Ovis aries benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O - Klebsiella pneumoniae benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O - Nocardia sp. benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O - Ipomoea batatas benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O - Culex quinquefasciatus benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O - Ctenopharyngodon idella benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O promotion-associated enzyme, no activity with phenobarbital-inducible enzyme Rattus norvegicus benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O 73.9% activity compared to p-tolualdehyde Sphingomonas sp. benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O 72.38% activity compared to formaldehyde Geobacillus thermodenitrificans benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O best substrate, isoform ALDH1 shows 2fold greater catalytic activity against benzaldehyde than against other substrates, while isoform ALDH2 shows no substrate preferences Phanerodontia chrysosporium benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O low affinity for benzaldehyde Homo sapiens benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O the activity on benzaldehyde is 35% of that on 3-hydroxypropionaldehyde Klebsiella pneumoniae benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O 35.5% activity compared to acetaldehyde Sulfurisphaera tokodaii benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O - Nocardia sp. 239 benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O - Klebsiella pneumoniae DSM 2026 benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O the activity on benzaldehyde is 35% of that on 3-hydroxypropionaldehyde Klebsiella pneumoniae DSM 2026 benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O 35.5% activity compared to acetaldehyde Sulfurisphaera tokodaii 7 benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O 73.9% activity compared to p-tolualdehyde Sphingomonas sp. 14DN-61 benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NAD+ + H2O 72.38% activity compared to formaldehyde Geobacillus thermodenitrificans NG80-2 benzoate + NADH + H+ - ? 189127 1.2.1.3 benzaldehyde + NADP+ - Rattus norvegicus benzoate + NADPH - ? 231666 1.2.1.3 benzaldehyde + NADP+ + H2O - Escherichia coli benzoate + NADPH + H+ - ? 372516 1.2.1.3 betaine aldehyde + NAD+ + H2O - Homo sapiens betaine + NADH - ? 231536 1.2.1.3 betaine aldehyde + NAD+ + H2O - Homo sapiens betaine + NADH + H+ - ? 189128 1.2.1.3 butyraldehyde + NAD+ + H2O the activity on butyraldehyde is about 95% of that on valeraldehyde Klebsiella pneumoniae butanoate + NADH + H+ - ? 414400 1.2.1.3 butyraldehyde + NAD+ + H2O - Escherichia coli butanoic acid + NADH + H+ - ? 400586 1.2.1.3 butanal + NAD+ + H2O - Rattus norvegicus butyrate + NADH + H+ - ? 231493 1.2.1.3 butanal + NAD+ + H2O - Sus scrofa butyrate + NADH + H+ - ? 231493 1.2.1.3 butanal + NAD+ + H2O - Ovis aries butyrate + NADH + H+ - ? 231493 1.2.1.3 butanal + NAD+ + H2O - Pseudomonas aeruginosa butyrate + NADH + H+ - ? 231493 1.2.1.3 butanal + NAD+ + H2O - Rhodococcus erythropolis butyrate + NADH + H+ - ? 231493 1.2.1.3 butanal + NAD+ + H2O n-butanal Rattus norvegicus butyrate + NADH + H+ - ? 231493 1.2.1.3 butanal + NAD+ + H2O n-butanal Oryctolagus cuniculus butyrate + NADH + H+ - ? 231493 1.2.1.3 butanal + NAD+ + H2O - Rhodococcus erythropolis UPV-1 butyrate + NADH + H+ - ? 231493 1.2.1.3 butyraldehyde + NAD+ + H2O - Vitis quinquangularis butyrate + NADH + H+ - ? 189121 1.2.1.3 butyraldehyde + NAD+ + H2O - Vitis labrusca butyrate + NADH + H+ - ? 189121 1.2.1.3 butyraldehyde + NAD+ + H2O - Lachnoclostridium phytofermentans butyrate + NADH + H+ - ? 189121 1.2.1.3 butyraldehyde + NAD+ + H2O 71.65% activity compared to formaldehyde Geobacillus thermodenitrificans butyrate + NADH + H+ - ? 189121 1.2.1.3 butyraldehyde + NAD+ + H2O 48.15% activity compared to acetaldehyde Sulfurisphaera tokodaii butyrate + NADH + H+ - ? 189121 1.2.1.3 butyraldehyde + NAD+ + H2O 48.15% activity compared to acetaldehyde Sulfurisphaera tokodaii 7 butyrate + NADH + H+ - ? 189121 1.2.1.3 butyraldehyde + NAD+ + H2O 71.65% activity compared to formaldehyde Geobacillus thermodenitrificans NG80-2 butyrate + NADH + H+ - ? 189121 1.2.1.3 chloroacetaldehyde + NAD+ + H2O - Homo sapiens chloroacetate + NADH + H+ - ? 231525 1.2.1.3 chloroacetaldehyde + NAD+ + H2O activity is twice as fast as with acetaldehyde, native enzyme and mutant enzyme E487K Homo sapiens chloroacetate + NADH + H+ - ? 231525 1.2.1.3 chloroacetaldehyde + NAD+ + H2O activity is twice as fast as with acetaldehyde, native enzyme and mutant enzyme E487K Rattus norvegicus chloroacetate + NADH + H+ - ? 231525 1.2.1.3 cinnamaldehyde + NAD+ + H2O 15.5% activity compared to p-tolualdehyde Sphingomonas sp. cinnamate + NADH + H+ - ? 231664 1.2.1.3 cinnamaldehyde + NAD+ + H2O 15.5% activity compared to p-tolualdehyde Sphingomonas sp. 14DN-61 cinnamate + NADH + H+ - ? 231664 1.2.1.3 cinnamic aldehyde + NAD+ + H2O - Homo sapiens cinnamic acid + NADH + H+ - ? 404667 1.2.1.3 crotonaldehyde + NAD+ + H2O - Rattus norvegicus crotonate + NADH - ? 231506 1.2.1.3 cyclohexanaldehyde + NAD+ + H2O - Sus scrofa cyclohexanoate + NADH - ? 231528 1.2.1.3 D-glucose + NAD+ + H2O - Ovis aries D-glucuronic acid + NADH - ? 231540 1.2.1.3 D-glyceraldehyde + NAD+ + H2O - Rattus norvegicus D-glycerate + NADH + H+ - r 423256 1.2.1.3 D-glyceraldehyde + NAD+ + H2O 50.25% activity compared to acetaldehyde Sulfurisphaera tokodaii D-glycerate + NADH + H+ - ? 423256 1.2.1.3 dansyl-aminoacetaldehyde + ? the fluorescent substrate is used to monitor aldehyde dehydrogenase activity in fluorescence-activated cell sorting Homo sapiens dansylglycine + ? - ? 388485 1.2.1.3 decanal + NAD+ + H2O - Escherichia coli decanaote + NADH - ? 373021 1.2.1.3 decanal + NAD+ + H2O - Homo sapiens decanoate + NADH - ? 231500 1.2.1.3 decanal + NAD+ + H2O - Rattus norvegicus decanoate + NADH - ? 231500 1.2.1.3 decanal + NAD+ + H2O - Sus scrofa decanoate + NADH - ? 231500 1.2.1.3 decanal + NAD+ + H2O - Ovis aries decanoate + NADH - ? 231500 1.2.1.3 decanal + NAD+ + H2O - Pseudomonas aeruginosa decanoate + NADH - ? 231500 1.2.1.3 decanal + NAD+ + H2O n-decylaldehyde Oryctolagus cuniculus decanoate + NADH - ? 231500 1.2.1.3 decanal + NAD+ + H2O n-decylaldehyde Ipomoea batatas decanoate + NADH - ? 231500 1.2.1.3 decanaldehyde + NAD+ + H2O 50.3% activity compared to formaldehyde Geobacillus thermodenitrificans decanoate + NADH + H+ - ? 414528 1.2.1.3 DL-glyceraldehyde + NAD+ + H2O 77.27% activity compared to acetaldehyde Sulfurisphaera tokodaii DL-glycerate + NADH + H+ - ? 353380 1.2.1.3 DL-glyceraldehyde + NAD+ + H2O low activity with NADP+ Sulfurisphaera tokodaii DL-glycerate + NADH + H+ - ? 353380 1.2.1.3 DL-glyceraldehyde 3-phosphate + NAD+ + H2O 52.7% activity compared to acetaldehyde Sulfurisphaera tokodaii DL-glycerate 3-phosphate + NADH + H+ - ? 426341 1.2.1.3 dodecanal + NAD+ + H2O n-dodecylaldehyde Oryctolagus cuniculus dodecanoate + NADH - ? 231501 1.2.1.3 dodecanal + NAD+ + H2O - Arabidopsis thaliana dodecanoate + NADH + H+ - ? 426345 1.2.1.3 dodecanal + NAD+ + H2O best substrate Arabidopsis thaliana dodecanoate + NADH + H+ - ? 426345 1.2.1.3 dodecanaldehyde + NAD+ + H2O 42.02% activity compared to formaldehyde Geobacillus thermodenitrificans dodecanoate + NADH + H+ - ? 414580 1.2.1.3 eicosanoic aldehyde + NAD+ + H2O 8.79% activity compared to formaldehyde Geobacillus thermodenitrificans eicosanoate + NADH + H+ - ? 414585 1.2.1.3 fluorene-2-carboxaldehyde + NAD+ + H2O - Homo sapiens fluorene-2-carboxylate + NADH - ? 231581 1.2.1.3 formaldehyde + NAD+ + H2O - Rattus norvegicus formate + NADH - ? 189231 1.2.1.3 formaldehyde + NAD+ + H2O - Ovis aries formate + NADH - ? 189231 1.2.1.3 formaldehyde + NAD+ + H2O - Nocardia sp. formate + NADH - ir 189231 1.2.1.3 formaldehyde + NAD+ + H2O - Rhodococcus erythropolis formate + NADH - ? 189231 1.2.1.3 formaldehyde + NAD+ + H2O no activity Rattus norvegicus formate + NADH - ? 189231 1.2.1.3 formaldehyde + NAD+ + H2O activity with cytosolic enzyme, no activity with microsomal enzyme Oryctolagus cuniculus formate + NADH - ? 189231 1.2.1.3 formaldehyde + NAD+ + H2O activity with enzyme ALDH-2, no activity with enzyme ALDH-1 Homo sapiens formate + NADH - ? 189231 1.2.1.3 formaldehyde + NAD+ + H2O - Nocardia sp. 239 formate + NADH - ir 189231 1.2.1.3 formaldehyde + NAD+ + H2O - Rhodococcus erythropolis UPV-1 formate + NADH - ? 189231 1.2.1.3 formaldehyde + NAD+ - Homo sapiens formate + NADH + H+ - ? 397187 1.2.1.3 formaldehyde + NAD+ + H2O - Homo sapiens formate + NADH + H+ - ? 231679 1.2.1.3 formaldehyde + NAD+ + H2O - Saccharomyces cerevisiae formate + NADH + H+ - ? 231679 1.2.1.3 formaldehyde + NAD+ + H2O 100% activity Geobacillus thermodenitrificans formate + NADH + H+ - ? 231679 1.2.1.3 formaldehyde + NAD+ + H2O 7.77% activity compared to acetaldehyde Sulfurisphaera tokodaii formate + NADH + H+ - ? 231679 1.2.1.3 formaldehyde + NAD+ + H2O - Saccharomyces cerevisiae ATCC 204508 formate + NADH + H+ - ? 231679 1.2.1.3 glutaraldehyde + NAD+ + H2O - Rattus norvegicus glutarate + NADH - ? 231503 1.2.1.3 glutathione-4-oxonon-2-enal + NAD+ + H2O - Homo sapiens glutathione-4-oxonon-2-enoic acid + NADH - ? 388834 1.2.1.3 glyceraldehyde + NAD+ + H2O - Homo sapiens glycerate + NADH - ? 231510 1.2.1.3 glyceraldehyde + NAD+ + H2O - Rattus norvegicus glycerate + NADH - ? 231510 1.2.1.3 glyceraldehyde + NAD+ + H2O - Bos taurus glycerate + NADH - ? 231510 1.2.1.3 glyceraldehyde + NAD+ + H2O - Ovis aries glycerate + NADH - ? 231510 1.2.1.3 glyceraldehyde + NAD+ + H2O - Homo sapiens glycerate + NADH + H+ - ? 231697 1.2.1.3 glyceraldehyde + NAD+ + H2O - Oryza sativa glycerate + NADH + H+ - ? 231697 1.2.1.3 glyceraldehyde 3-phosphate + NAD+ + H2O - Bos taurus glycerate 3-phosphate + NADH - ? 231511 1.2.1.3 glycolaldehyde + NAD+ + H2O - Homo sapiens glycolate + NADH - ? 189162 1.2.1.3 glycolaldehyde + NAD+ + H2O - Rattus norvegicus glycolate + NADH - ? 189162 1.2.1.3 glycolaldehyde + NAD+ + H2O - Bos taurus glycolate + NADH - ? 189162 1.2.1.3 glycolaldehyde + NAD+ + H2O the aldehyde dehydrogenase is a halophilic enzyme with the highest activity at 1 M NaCl Halobacterium salinarum glycolate + NADH - ? 189162 1.2.1.3 glycolaldehyde + NAD+ + H2O 75.43% activity compared to acetaldehyde Sulfurisphaera tokodaii glycolate + NADH + H+ - ? 373334 1.2.1.3 heptanal + NAD+ + H2O - Homo sapiens heptanoate + NADH - ? 231497 1.2.1.3 heptanal + NAD+ + H2O - Rattus norvegicus heptanoate + NADH - ? 231497 1.2.1.3 heptanal + NAD+ + H2O n-heptanal Oryctolagus cuniculus heptanoate + NADH - ? 231497 1.2.1.3 hexadecanal + NAD+ + H2O 15.77% activity compared to formaldehyde Geobacillus thermodenitrificans hexadecanoate + NADH + H+ - ? 414693 1.2.1.3 hexaldehyde + NAD+ + H2O 76.21% activity compared to formaldehyde Geobacillus thermodenitrificans hexanoate + NADH + H+ - ? 414695 1.2.1.3 hexanal + NAD+ + H2O - Homo sapiens hexanoate + NADH + H+ - ? 189252 1.2.1.3 hexanal + NAD+ + H2O - Rattus norvegicus hexanoate + NADH + H+ - ? 189252 1.2.1.3 hexanal + NAD+ + H2O - Oryctolagus cuniculus hexanoate + NADH + H+ - ? 189252 1.2.1.3 hexanal + NAD+ + H2O - Arabidopsis thaliana hexanoate + NADH + H+ - ? 189252 1.2.1.3 hexanal + NAD+ + H2O - Pseudomonas aeruginosa hexanoate + NADH + H+ - ? 189252 1.2.1.3 hexanal + NAD+ + H2O - Rhodococcus erythropolis hexanoate + NADH + H+ - ? 189252 1.2.1.3 hexanal + NAD+ + H2O - Loktanella sp. hexanoate + NADH + H+ - ? 189252 1.2.1.3 hexanal + NAD+ + H2O - Thermus thermophilus hexanoate + NADH + H+ - ? 189252 1.2.1.3 hexanal + NAD+ + H2O high specificity Homo sapiens hexanoate + NADH + H+ - ? 189252 1.2.1.3 hexanal + NAD+ + H2O n-hexanal Oryctolagus cuniculus hexanoate + NADH + H+ - ? 189252 1.2.1.3 hexanal + NAD+ + H2O n-hexanal Ipomoea batatas hexanoate + NADH + H+ - ? 189252 1.2.1.3 hexanal + NAD+ + H2O - Thermus thermophilus DSM 7039 hexanoate + NADH + H+ - ? 189252 1.2.1.3 hexanal + NAD+ + H2O - Rhodococcus erythropolis UPV-1 hexanoate + NADH + H+ - ? 189252 1.2.1.3 hexanal + NAD+ + H2O - Thermus thermophilus ATCC BAA-163 hexanoate + NADH + H+ - ? 189252 1.2.1.3 hexanaldehyde + NAD+ + H2O - Lachnoclostridium phytofermentans hexanoate + NADH + H+ - ? 439608 1.2.1.3 hydrocinnamaldehyde + NAD+ + H2O - Homo sapiens hydrocinnamate + NADH - ? 231546 1.2.1.3 indole-3-acetaldehyde + NAD+ + H2O - Homo sapiens indole-3-acetate + NADH + H+ - ? 231578 1.2.1.3 indole-3-acetaldehyde + NAD+ + H2O - Ovis aries indole-3-acetate + NADH + H+ - ? 231578 1.2.1.3 indole-3-aldehyde + NAD+ + H2O - Homo sapiens indole-3-carboxylate + NADH - ? 231577 1.2.1.3 indole-3-aldehyde + NAD+ + H2O - Sus scrofa indole-3-carboxylate + NADH - ? 231577 1.2.1.3 isobutanal + NAD+ + H2O - Rattus norvegicus isobutyrate + NADH - ? 231494 1.2.1.3 isovaleraldehyde + NAD+ + H2O - Escherichia coli isovalerate + NADH + H+ - ? 373502 1.2.1.3 isovaleraldehyde + NAD+ + H2O the activity on isovaleraldehyde is about 80% of that on valeraldehyde Klebsiella pneumoniae isovalerate + NADH + H+ - ? 373502 1.2.1.3 m-chlorobenzaldehyde + NAD+ + H2O 44.7% activity compared to p-tolualdehyde Sphingomonas sp. m-chlorobenzoic acid + NADH + H+ - ? 389117 1.2.1.3 m-fluorobenzaldehyde + NAD+ + H2O 52.6% activity compared to p-tolualdehyde Sphingomonas sp. m-fluorobenzoic acid + NADH + H+ - ? 258147 1.2.1.3 m-fluorobenzaldehyde + NAD+ + H2O 52.6% activity compared to p-tolualdehyde Sphingomonas sp. 14DN-61 m-fluorobenzoic acid + NADH + H+ - ? 258147 1.2.1.3 m-hydroxybenzaldehyde + NAD+ + H2O - Homo sapiens m-hydroxybenzoate + NADH + H+ - ? 231555 1.2.1.3 m-hydroxybenzaldehyde + NAD+ + H2O 23.6% activity compared to p-tolualdehyde Sphingomonas sp. m-hydroxybenzoic acid + NADH + H+ - ? 389119 1.2.1.3 m-methoxybenzaldehyde + NAD+ + H2O - Homo sapiens m-methoxybenzoate + NADH + H+ - ? 231553 1.2.1.3 m-methoxybenzaldehyde + NAD+ + H2O - Rattus norvegicus m-methoxybenzoate + NADH + H+ - ? 231553 1.2.1.3 m-methoxybenzaldehyde + NAD+ + H2O 88.5% activity compared to p-tolualdehyde Sphingomonas sp. m-methoxybenzoic acid + NADH + H+ - ? 389120 1.2.1.3 m-methylbenzaldehyde + NAD+ + H2O - Homo sapiens m-methylbenzoate + NADH - ? 231550 1.2.1.3 m-tolualdehyde + NAD+ + H2O 70.8% activity compared to p-tolualdehyde Sphingomonas sp. m-methylbenzoic acid + NADH - ? 389124 1.2.1.3 m-nitrobenzaldehyde + NAD+ + H2O - Rattus norvegicus m-nitrobenzoate + NADH - ? 189175 1.2.1.3 m-nitrobenzaldehyde + NAD+ + H2O - Ovis aries m-nitrobenzoate + NADH - ? 189175 1.2.1.3 m-nitrobenzaldehyde + NAD+ + H2O 46.8% activity compared to p-tolualdehyde Sphingomonas sp. m-nitrobenzoic acid + NADH - ? 389121 1.2.1.3 methylglyoxal + NAD+ + H2O - Homo sapiens methylglyoxalate + NADH - ? 231533 1.2.1.3 monochloroacetaldehyde + NAD+ + H2O - Rattus norvegicus monochloroacetate + NADH - ? 231504 1.2.1.3 N-acetyl-4-aminobutyraldehyde + NAD+ + H2O - Homo sapiens N-acetyl-4-aminobutyrate + NADH - ? 231538 1.2.1.3 n-nonanal + NAD+ + H2O - Homo sapiens n-nonanoate + NADH + H+ - ? 231499 1.2.1.3 n-nonanal + NAD+ + H2O - Oryctolagus cuniculus n-nonanoate + NADH + H+ - ? 231499 1.2.1.3 n-nonanal + NAD+ + H2O high specificity Homo sapiens n-nonanoate + NADH + H+ - ? 231499 1.2.1.3 nonanal + NAD+ + H2O - Arabidopsis thaliana nonanoate + NADH + H+ - ? 426850 1.2.1.3 o-chlorobenzaldehyde + NAD+ + H2O 3.4% activity compared to p-tolualdehyde Sphingomonas sp. o-chlorobenzoic acid + NADH + H+ - ? 389420 1.2.1.3 o-fluorobenzaldehyde + NAD+ + H2O 81.6% activity compared to p-tolualdehyde Sphingomonas sp. o-fluorobenzoic acid + NADH + H+ - ? 258146 1.2.1.3 o-fluorobenzaldehyde + NAD+ + H2O 81.6% activity compared to p-tolualdehyde Sphingomonas sp. 14DN-61 o-fluorobenzoic acid + NADH + H+ - ? 258146 1.2.1.3 o-hydroxybenzaldehyde + NAD+ + H2O - Homo sapiens o-hydroxybenzoate + NADH + H+ - ? 231556 1.2.1.3 o-hydroxybenzaldehyde + NAD+ + H2O 65.2% activity compared to p-tolualdehyde Sphingomonas sp. o-hydroxybenzoic acid + NADH + H+ - ? 389424 1.2.1.3 o-methoxybenzaldehyde + NAD+ + H2O - Homo sapiens o-methoxybenzoate + NADH + H+ - ? 231554 1.2.1.3 o-methoxybenzaldehyde + NAD+ + H2O 2.6% activity compared to p-tolualdehyde Sphingomonas sp. o-methoxybenzoic acid + NADH + H+ - ? 389425 1.2.1.3 o-methylbenzaldehyde + NAD+ + H2O - Homo sapiens o-methylbenzoate + NADH - ? 231551 1.2.1.3 o-tolualdehyde + NAD+ + H2O 3.7% activity compared to p-tolualdehyde Sphingomonas sp. o-methylbenzoic acid + NADH - ? 389430 1.2.1.3 o-nitrobenzaldehyde + NAD+ + H2O - Homo sapiens o-nitrobenzoate + NADH - ? 231515 1.2.1.3 o-nitrobenzaldehyde + NAD+ + H2O 17.8% activity compared to p-tolualdehyde Sphingomonas sp. o-nitrobenzoic acid + NADH - ? 389426 1.2.1.3 octadecanal + NAD+ + H2O 12% activity compared to formaldehyde Geobacillus thermodenitrificans octadecanoate + NADH + H+ - ? 415065 1.2.1.3 octanal + NAD+ + H2O - Homo sapiens octanoate + NADH - ? 231498 1.2.1.3 octanal + NAD+ + H2O - Pseudomonas aeruginosa octanoate + NADH - ? 231498 1.2.1.3 octanal + NAD+ + H2O - Acanthopagrus schlegelii octanoate + NADH - ? 231498 1.2.1.3 octanal + NAD+ + H2O - Rhodococcus erythropolis octanoate + NADH - ? 231498 1.2.1.3 octanal + NAD+ + H2O n-octylaldehyde Oryctolagus cuniculus octanoate + NADH - ? 231498 1.2.1.3 octanal + NAD+ + H2O - Rhodococcus erythropolis UPV-1 octanoate + NADH - ? 231498 1.2.1.3 octanal + NAD+ + H2O - Arabidopsis thaliana octanoate + NADH + H+ - ? 189254 1.2.1.3 octanal + NAD+ + H2O high specificity Homo sapiens octanoate + NADH + H+ - ? 189254 1.2.1.3 octyl aldehyde + NAD+ + H2O 72.27% activity compared to formaldehyde Geobacillus thermodenitrificans octanoate + NADH + H+ - ? 415071 1.2.1.3 glyoxal + NAD+ + H2O - Rattus norvegicus oxalate + NADH - ? 231505 1.2.1.3 p-(dimethylamino)-benzaldehyde + NAD+ + H2O - Homo sapiens p-(dimethylamino)benzoate + NADH - ? 231557 1.2.1.3 p-(dimethylamino)cinnamaldehyde + NAD+ + H2O - Homo sapiens p-(dimethylamino)cinnamate + NADH - ? 231544 1.2.1.3 p-(dimethylamino)cinnamaldehyde + NAD+ + H2O - Rattus norvegicus p-(dimethylamino)cinnamate + NADH - ? 231544 1.2.1.3 p-carboxybenzaldehyde + NAD+ + H2O - Rattus norvegicus p-carboxybenzoate + NADH - ? 231508 1.2.1.3 p-chlorobenzaldehyde + NAD+ + H2O 79.6% activity compared to p-tolualdehyde Sphingomonas sp. p-chlorobenzoic acid + NADH + H+ - ? 258149 1.2.1.3 p-fluorobenzaldehyde + NAD+ + H2O 65.5%activity compared to p-tolualdehyde Sphingomonas sp. p-fluorobenzoic acid + NADH + H+ - ? 258148 1.2.1.3 p-fluorobenzaldehyde + NAD+ + H2O 65.5%activity compared to p-tolualdehyde Sphingomonas sp. 14DN-61 p-fluorobenzoic acid + NADH + H+ - ? 258148 1.2.1.3 p-hydroxybenzaldehyde + NAD+ + H2O 4.2% activity compared to p-tolualdehyde Sphingomonas sp. p-hydroxybenzoic acid + NADH + H+ - ? 389472 1.2.1.3 p-hydroxyphenylacetaldehyde + NAD+ + H2O - Sus scrofa p-hydroxyphenylacetate + NADH - ? 231519 1.2.1.3 p-hydroxyphenylacetaldehyde + NAD+ + H2O - Ovis aries p-hydroxyphenylacetate + NADH - ? 231519 1.2.1.3 p-methoxybenzaldehyde + NAD+ + H2O - Homo sapiens p-methoxybenzoate + NADH + H+ - ? 231518 1.2.1.3 p-methoxybenzaldehyde + NAD+ + H2O - Rattus norvegicus p-methoxybenzoate + NADH + H+ - ? 231518 1.2.1.3 p-methoxybenzaldehyde + NAD+ + H2O - Ovis aries p-methoxybenzoate + NADH + H+ - ? 231518 1.2.1.3 p-methoxybenzaldehyde + NAD+ + H2O 6.2% activity compared to p-tolualdehyde Sphingomonas sp. p-methoxybenzoic acid + NADH + H+ - ? 389477 1.2.1.3 p-methylbenzaldehyde + NAD+ + H2O - Homo sapiens p-methylbenzoate + NADH - ? 231549 1.2.1.3 p-tolualdehyde + NAD+ + H2O highest activity Sphingomonas sp. p-methylbenzoic acid + NADH - ? 389490 1.2.1.3 p-nitrobenzaldehyde + NAD+ + H2O - Homo sapiens p-nitrobenzoate + NADH - ? 189174 1.2.1.3 p-nitrobenzaldehyde + NAD+ + H2O - Rattus norvegicus p-nitrobenzoate + NADH - ? 189174 1.2.1.3 p-nitrobenzaldehyde + NAD+ + H2O - Sus scrofa p-nitrobenzoate + NADH - ? 189174 1.2.1.3 p-nitrobenzaldehyde + NAD+ + H2O - Bos taurus p-nitrobenzoate + NADH - ? 189174 1.2.1.3 p-nitrobenzaldehyde + NAD+ + H2O - Ovis aries p-nitrobenzoate + NADH - ? 189174 1.2.1.3 p-nitrobenzaldehyde + NAD+ + H2O 69% activity compared to p-tolualdehyde Sphingomonas sp. p-nitrobenzoic acid + NADH - ? 389479 1.2.1.3 p-nitrocinnamaldehyde + NAD+ + H2O - Homo sapiens p-nitrocinnamate + NADH - ? 231543 1.2.1.3 p-nitrophenyl acetate + H2O esterase activity of the various isoenzymes is less than 7% of the activity with propanal and NAD+ Rattus norvegicus p-nitrophenol + acetate - ? 36053 1.2.1.3 pentanal + NAD+ + H2O - Homo sapiens pentanoate + NADH - ? 231495 1.2.1.3 pentanal + NAD+ + H2O - Rattus norvegicus pentanoate + NADH - ? 231495 1.2.1.3 pentanal + NAD+ + H2O n-pentanal Oryctolagus cuniculus pentanoate + NADH - ? 231495 1.2.1.3 pentanaldehyde + NAD+ + H2O - Lachnoclostridium phytofermentans pentanoate + NADH + H+ - ? 439814 1.2.1.3 phenanthrene-9-carboxaldehyde + NAD+ + H2O - Homo sapiens phenanthrene-9-carboxylate + NADH - ? 231576 1.2.1.3 phenylacetaldehyde + NAD+ + H2O - Homo sapiens phenylacetate + NADH + H+ - ? 231521 1.2.1.3 phenylacetaldehyde + NAD+ + H2O - Rattus norvegicus phenylacetate + NADH + H+ - ? 231521 1.2.1.3 phenylacetaldehyde + NAD+ + H2O - Bos taurus phenylacetate + NADH + H+ - ? 231521 1.2.1.3 phenylacetaldehyde + NAD+ + H2O best substrate Escherichia coli phenylacetate + NADH + H+ - ? 231521 1.2.1.3 phenylacetaldehyde + NAD+ + H2O 37.86% activity compared to formaldehyde Geobacillus thermodenitrificans phenylacetate + NADH + H+ - ? 231521 1.2.1.3 phenylacetaldehyde + NAD+ + H2O 4.21% activity compared to acetaldehyde Sulfurisphaera tokodaii phenylacetate + NADH + H+ - ? 231521 1.2.1.3 phosphonoacetaldehyde + NAD+ + H2O - Sinorhizobium meliloti phosphonoacetate + NADH + H+ - ? 429362 1.2.1.3 2-phthalaldehyde + NAD+ + H2O 10.81% activity compared to formaldehyde Geobacillus thermodenitrificans phthalate + NADH + H+ - ? 413989 1.2.1.3 pivaldehyde + NAD+ + H2O - Sus scrofa pivalate + NADH - ? 231529 1.2.1.3 propanal + [5-(3-acetylpyridino)pentyl]diphosphoadenosine + H2O - Equus caballus propanoate + ? - ? 231589 1.2.1.3 propanal + NAD+ + H2O - Homo sapiens propanoate + NADH + H+ - ? 258113 1.2.1.3 propanal + NAD+ + H2O - Saccharomyces cerevisiae propanoate + NADH + H+ - ? 258113 1.2.1.3 propanal + NAD+ + H2O - Acanthopagrus schlegelii propanoate + NADH + H+ - ? 258113 1.2.1.3 propanal + NAD+ + H2O - Rhodococcus erythropolis propanoate + NADH + H+ - ? 258113 1.2.1.3 propanal + NAD+ + H2O - Rhodococcus erythropolis UPV-1 propanoate + NADH + H+ - ? 258113 1.2.1.3 propionaldehyde + NAD+ + H2O - Arabidopsis thaliana propanoate + NADH + H+ - ? 421224 1.2.1.3 propionaldehyde + NAD+ + H2O - Vitis quinquangularis propanoate + NADH + H+ - ? 421224 1.2.1.3 propionaldehyde + NAD+ + H2O - Vitis labrusca propanoate + NADH + H+ - ? 421224 1.2.1.3 propionaldehyde + NAD+ + H2O - Lachnoclostridium phytofermentans propanoate + NADH + H+ - ? 421224 1.2.1.3 propanal + NAD+ + H2O activity assay Homo sapiens propanoic acid + NADH + H+ - ? 406475 1.2.1.3 propionaldehyde + NAD+ + H2O - Escherichia coli propanoic acid + NADH + H+ - ? 401808 1.2.1.3 propanal + 3-acetylpyridine-NAD+ + H2O - Rattus norvegicus propionate + 3-acetylpyridine-NADH - ? 231524 1.2.1.3 propanal + 1,N6-ethenoadenine dinucleotide + H2O isoenzyme E3 Homo sapiens propionate + ? - ? 231584 1.2.1.3 propanal + 3-acetylpyridine-adenine dinucleotide + H2O isoenzyme E3 Homo sapiens propionate + ? - ? 231587 1.2.1.3 propanal + 3-thionicotinamide-adenine dinucleotide + H2O isoenzyme E3 Homo sapiens propionate + ? - ? 231588 1.2.1.3 propanal + N-guanine dinucleotide + H2O isoenzyme E3 Homo sapiens propionate + ? - ? 231586 1.2.1.3 propanal + deamino-NAD+ + H2O - Rattus norvegicus propionate + deamino-NADH - ? 231523 1.2.1.3 propanal + NAD+ + H2O - Homo sapiens propionate + NADH - ? 231492 1.2.1.3 propanal + NAD+ + H2O - Rattus norvegicus propionate + NADH - ? 231492 1.2.1.3 propanal + NAD+ + H2O - Sus scrofa propionate + NADH - ? 231492 1.2.1.3 propanal + NAD+ + H2O - Bos taurus propionate + NADH - ? 231492 1.2.1.3 propanal + NAD+ + H2O - Oryctolagus cuniculus propionate + NADH - ? 231492 1.2.1.3 propanal + NAD+ + H2O - Euglena gracilis propionate + NADH - ? 231492 1.2.1.3 propanal + NAD+ + H2O - Ovis aries propionate + NADH - ? 231492 1.2.1.3 propanal + NAD+ + H2O - Pseudomonas aeruginosa propionate + NADH - ? 231492 1.2.1.3 propanal + NAD+ + H2O - Nocardia sp. propionate + NADH - ? 231492 1.2.1.3 propanal + NAD+ + H2O - Danio rerio propionate + NADH - ? 231492 1.2.1.3 propanal + NAD+ + H2O - Ctenopharyngodon idella propionate + NADH - ? 231492 1.2.1.3 propanal + NAD+ + H2O - Nocardia sp. 239 propionate + NADH - ? 231492 1.2.1.3 propionaldehyde + NAD+ + H2O - Homo sapiens propionate + NADH - ? 189178 1.2.1.3 propanal + NAD+ + H2O - Homo sapiens propionate + NADH + H+ - ? 231684 1.2.1.3 propanal + NAD+ + H2O - Rattus norvegicus propionate + NADH + H+ - ? 231684 1.2.1.3 propanal + NAD+ + H2O - Thermus thermophilus propionate + NADH + H+ - ? 231684 1.2.1.3 propanal + NAD+ + H2O - Thermus thermophilus DSM 7039 propionate + NADH + H+ - ? 231684 1.2.1.3 propanal + NAD+ + H2O - Thermus thermophilus ATCC BAA-163 propionate + NADH + H+ - ? 231684 1.2.1.3 propionaldehyde + NAD+ - Homo sapiens propionate + NADH + H+ - ? 398182 1.2.1.3 propionaldehyde + NAD+ + H2O - Homo sapiens propionate + NADH + H+ - ? 189122 1.2.1.3 propionaldehyde + NAD+ + H2O - Rattus norvegicus propionate + NADH + H+ - ? 189122 1.2.1.3 propionaldehyde + NAD+ + H2O - Saccharomyces cerevisiae propionate + NADH + H+ - ? 189122 1.2.1.3 propionaldehyde + NAD+ + H2O - Bos taurus propionate + NADH + H+ - ? 189122 1.2.1.3 propionaldehyde + NAD+ + H2O - Bacillus licheniformis propionate + NADH + H+ - ? 189122 1.2.1.3 propionaldehyde + NAD+ + H2O the activity on propionaldehyde is about 55% of that on valeraldehyde Klebsiella pneumoniae propionate + NADH + H+ - ? 189122 1.2.1.3 propionaldehyde + NAD+ + H2O 56.22% activity compared to acetaldehyde Sulfurisphaera tokodaii propionate + NADH + H+ - ? 189122 1.2.1.3 propionaldehyde + NAD+ + H2O the activity on propionaldehyde is about 55% of that on valeraldehyde Klebsiella pneumoniae DSM 2026 propionate + NADH + H+ - ? 189122 1.2.1.3 propionaldehyde + NAD+ + H2O 56.22% activity compared to acetaldehyde Sulfurisphaera tokodaii 7 propionate + NADH + H+ - ? 189122 1.2.1.3 propanal + oxidized nicotinamide hypoxanthine dinucleotide + H2O isoenzyme E3 Homo sapiens propionate + reduced nicotinamide hypoxanthine dinucleotide - ? 231585 1.2.1.3 protocatechaldehyde + NAD+ + H2O 4.5% activity compared to p-tolualdehyde Sphingomonas sp. protocatechuic acid + NADH - ? 389611 1.2.1.3 1-formylpyrene + NAD+ - Homo sapiens pyrene 1-carboxylate + NADH + H+ - ? 395248 1.2.1.3 2-formylpyrene + NAD+ - Homo sapiens pyrene 2-carboxylate + NADH + H+ - ? 395527 1.2.1.3 4-formylpyrene + NAD+ - Homo sapiens pyrene 4-carboxylate + NADH + H+ - ? 395860 1.2.1.3 1-formylpyrene + NAD+ + H2O - Homo sapiens pyrene-1-carboxylic acid + NADH + H+ - ? 399270 1.2.1.3 2-formylpyrene + NAD+ + H2O - Homo sapiens pyrene-2-carboxylic acid + NADH + H+ - ? 399428 1.2.1.3 4-formylpyrene + NAD+ + H2O - Homo sapiens pyrene-4-carboxylic acid + NADH + H+ - ? 399649 1.2.1.3 pyridine 3-aldehyde + NAD+ + H2O - Sus scrofa pyridine-3-carboxylate + NADH - ? 231542 1.2.1.3 pyridine-3-aldehyde adenine dinucleotide + NAD+ + H2O - Ovis aries pyridine-3-carboxylate adenine dinucleotide + NADH - ? 231541 1.2.1.3 pyruvic aldehyde + NAD+ + H2O - Rattus norvegicus pyruvate + NADH - ? 231507 1.2.1.3 quinoline-3-carboxaldehyde + NAD+ + H2O - Homo sapiens quinoline-3-carboxylate + NADH - ? 231570 1.2.1.3 quinoline-4-carboxaldehyde + NAD+ + H2O - Homo sapiens quinoline-4-carboxylate + NADH - ? 231571 1.2.1.3 retinal + NAD+ + H2O - Homo sapiens retinoic acid + NADH + H+ - ? 389649 1.2.1.3 retinol + NAD+ + H2O - Oryzias latipes retinoic acid + NADH + H+ - ? 413563 1.2.1.3 succinic semialdehyde + NAD+ + H2O - Bos taurus succinate + NADH - ? 231534 1.2.1.3 succinic semialdehyde + NAD+ + H2O - Escherichia coli succinate + NADH - ? 231534 1.2.1.3 syringaldehyde + NAD+ + H2O 65.1% activity compared to p-tolualdehyde Sphingomonas sp. syringic acid + NADH - ? 389844 1.2.1.3 tetradecanal + NAD+ + H2O high activity Geobacillus thermoleovorans tetradecanoate + NADH - ? 415360 1.2.1.3 tetradecanal + NAD+ + H2O high activity Geobacillus thermoleovorans B23 tetradecanoate + NADH - ? 415360 1.2.1.3 tetradecyl aldehyde + NAD+ + H2O 11.71% activity compared to formaldehyde Geobacillus thermodenitrificans tetradecanoate + NADH + H+ - ? 415362 1.2.1.3 trans-cinnamaldehyde + NAD+ + H2O - Homo sapiens trans-cinnamate + NADH - ? 231532 1.2.1.3 trans-cinnamaldehyde + NAD+ + H2O - Sus scrofa trans-cinnamate + NADH - ? 231532 1.2.1.3 chloral + NAD+ + H2O 2.67% activity compared to acetaldehyde Sulfurisphaera tokodaii trichloroacetate + NADH + H+ - ? 426097 1.2.1.3 valeraldehyde + NAD+ + H2O - Escherichia coli valerate + NADH + H+ - ? 189120 1.2.1.3 valeraldehyde + NAD+ + H2O most preferred substrate, 100% activity Klebsiella pneumoniae valerate + NADH + H+ - ? 189120 1.2.1.3 valeraldehyde + NAD+ + H2O most preferred substrate, 100% activity Klebsiella pneumoniae DSM 2026 valerate + NADH + H+ - ? 189120 1.2.1.3 vanillin + NAD+ + H2O - Phanerodontia chrysosporium vanillic acid + NADH + H+ - ? 390072 1.2.1.3 vanillin + NAD+ + H2O 62.3% activity compared to p-tolualdehyde Sphingomonas sp. vanillic acid + NADH + H+ - ? 390072