1.14.14.124 3alpha-hydroxy-3,5-dihydromonacolin L acid spontaneous Monascus ruber monacolin L acid + H2O (1b), spontaneous 428008 1.14.14.124 3alpha-hydroxy-3,5-dihydromonacolin L acid spontaneous Aspergillus terreus monacolin L acid + H2O (1b), spontaneous 428008 1.14.14.124 dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 - Aspergillus terreus 3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O product is unstable und under mildly acidic conditions and elevated temperature, it converts to monacolin L 427428 1.14.14.124 dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 dihydromonacolin L acid i.e. (3R,5R)-7-[(1S,2S,4aR,6R,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen1yl]-3,5-dihydroxyheptanoate. The enzyme also catalyses the reaction of EC 1.14.14.124, monacolin L hydroxylase. The enzyme is involved in the biosynthesis of lovastatin Aspergillus terreus 3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O - 427428 1.14.14.124 dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 dihydromonacolin L acid i.e. (3R,5R)-7-[(1S,2S,4aR,6R,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen1yl]-3,5-dihydroxyheptanoate Monascus ruber 3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O - 427428 1.14.14.124 dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 dihydromonacolin L acid i.e. (3R,5R)-7-[(1S,2S,4aR,6R,8aS)-2,6-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen1yl]-3,5-dihydroxyheptanoate. The enzyme also catalyses the reaction of EC 1.14.14.124, monacolin L hydroxylase Aspergillus terreus 3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O - 427428 1.14.14.124 dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 reaction of cell free extract in presence of air Monascus ruber 3alpha-hydroxy-3,5-dihydromonacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O - 427428 1.14.14.124 dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 monacolin L acid i.e. (3R,5R)-7-[(1S,2S,6R,8aR)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate Monascus ruber monacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O - 428574 1.14.14.124 dihydromonacolin L acid + [reduced NADPH-hemoprotein reductase] + O2 monacolin L acid i.e. (3R,5R)-7-[(1S,2S,6R,8aR)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate. The enzyme also catalyses the reaction of EC 1.14.13.198, monacolin L hydroxylase Aspergillus terreus monacolin L acid + [oxidized NADPH-hemoprotein reductase] + H2O - 428574