1.14.11.31	(R,S)-canadine + 2-oxoglutarate + O2	a protoberberine, 32% of activity with oripavine	Papaver somniferum	?	-	?	425175	
1.14.11.31	(R,S)-tetrahydropalmatine + 2-oxoglutarate + O2	a protoberberine, O-demethylation, below 1% of activity with oripavine	Papaver somniferum	?	-	?	425176	
1.14.11.31	(R,S)-tetrahydropapaverine + 2-oxoglutarate + O2	a 1-benzylisoquinoline, O-demethylation, 2.1% of activity with oripavine	Papaver somniferum	?	-	?	425177	
1.14.11.31	allocryptopine + 2-oxoglutarate + O2	a protopine, O-demethylation, 9.5% of activity with oripavine	Papaver somniferum	?	-	?	425903	
1.14.11.31	cryptopine + 2-oxoglutarate + O2	a protopine, O-demethylation, below 1% of activity with oripavine	Papaver somniferum	?	-	?	426154	
1.14.11.31	additional information	no activity with (S)-reticuline, (S)-scoulerine, papaverine, (S)-corytuberine, pavine, salutaridine, noscapine, codeine	Papaver somniferum	?	-	?	89	
1.14.11.31	additional information	when assayed with a wide range of benzylisoquinoline alkaloids, the enzyme shows efficient dealkylation activities, including regio- and substrate-specific O-demethylation and O,O-demethylenation, substrate specificity, overview. No or poor activity with (S)-reticuline, (S)-isocorydine, (S)-scoulerine, (R,S)-stylopine, berberine, O-demethylcryptopine, protopine, and codeine	Papaver somniferum	?	-	?	89	
1.14.11.31	oripavine + 2-oxoglutarate + O2	-	Papaver somniferum	morphinone + formaldehyde + succinate + CO2	-	?	402808	
1.14.11.31	oripavine + 2-oxoglutarate + O2	a step of morphine biosynthesis	Papaver somniferum	morphinone + formaldehyde + succinate + CO2	-	?	402808	
1.14.11.31	oripavine + 2-oxoglutarate + O2	alkyl hydroxylation proceeds through a radical mechanism involving an iron-oxo intermediate, followed by the elimination of formaldehyde	Papaver somniferum	morphinone + formaldehyde + succinate + CO2	-	?	402808	
1.14.11.31	oripavine + 2-oxoglutarate + O2	a morphinan, best substrate	Papaver somniferum	?	-	?	426885	
1.14.11.31	oripavine + 2-oxoglutarate + O2	-	Papaver orientale	morphinane + formaldehyde + succinate + CO2	-	?	440366	
1.14.11.31	papaverine + 2-oxoglutarate + O2	a 1-benzylisoquinoline,O-demethylation, below 1% of activity with oripavine	Papaver somniferum	?	-	?	426899	
1.14.11.31	thebaine + 2-oxoglutarate + O2	-	Papaver somniferum	neopinone + formaldehyde + succinate + CO2	-	?	402942	
1.14.11.31	thebaine + 2-oxoglutarate + O2	a step of morphine biosynthesis	Papaver somniferum	neopinone + formaldehyde + succinate + CO2	spontaneous conversion to codeinone	?	402942	
1.14.11.31	thebaine + 2-oxoglutarate + O2	85% of the activity with oripavine. Alkyl hydroxylation proceeds through a radical mechanism involving an iron-oxo intermediate, followed by the elimination of formaldehyde	Papaver somniferum	neopinone + formaldehyde + succinate + CO2	spontaneous conversion to codeinone	?	402942	
1.14.11.31	thebaine + 2-oxoglutarate + O2	a morphinan, 97.2% of activity with oripavine	Papaver somniferum	neopinone + formaldehyde + succinate + CO2	-	?	402942	
1.14.11.31	thebaine + 2-oxoglutarate + O2	-	Papaver orientale	codeinone + formaldehyde + succinate + CO2	-	?	440409