1.1.1.49 2-deoxy-D-glucose 6-phosphate + NAD(P)+ low activity Thermotoga maritima 2-deoxy-D-glucono-1,5-lactone 6-phosphate + NAD(P)H - ? 371665 1.1.1.49 2-deoxy-D-glucose 6-phosphate + NADP+ - Canis lupus familiaris 2-deoxy-D-glucono-1,5-lactone 6-phosphate + NADPH - ? 355813 1.1.1.49 2-deoxy-D-glucose 6-phosphate + NADP+ wild-type and mutant P409R, below 10% activity compared to D-glucose 6-phosphate Homo sapiens 2-deoxy-D-glucono-1,5-lactone 6-phosphate + NADPH - ? 355813 1.1.1.49 2-deoxy-D-glucose 6-phosphate + NADP+ - Homo sapiens ? - ? 388517 1.1.1.49 2-deoxy-D-glucose-6-phosphate + NADP+ - Homo sapiens 2-deoxy-D-gluconate 6-phosphate + NADPH - ? 188197 1.1.1.49 6-phosphonogluconate + NADPH isoenzyme II Homo sapiens ? - ? 188198 1.1.1.49 6-phosphonogluconate + NADPH isoenzyme II Sus scrofa ? - ? 188198 1.1.1.49 D-galactose 6-phosphate + NAD(P)+ - Homo sapiens D-galactonate 6-phosphate + NADH - ? 188196 1.1.1.49 D-galactose 6-phosphate + NAD(P)+ - Sus scrofa D-galactonate 6-phosphate + NADH - ? 188196 1.1.1.49 D-glucose + NAD(P)+ activity only with dimethylsulfoxide added by 40% (v/v) Cryptococcus neoformans D-gluconate + NAD(P)H - ? 188195 1.1.1.49 D-glucose 6-phosphate + deamino-NADP+ - Canis lupus familiaris D-glucono-1,5-lactone 6-phosphate + deamino-NADPH - ? 372906 1.1.1.49 D-glucose 6-phosphate + deamino-NADP+ - Homo sapiens ? - ? 388450 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Mus musculus D-gluconate 6-phosphate + NADPH + H+ - ? 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Homo sapiens D-gluconate 6-phosphate + NADPH + H+ - ? 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Rattus norvegicus D-gluconate 6-phosphate + NADPH + H+ - ? 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Rattus norvegicus D-gluconate 6-phosphate + NADPH + H+ - ir 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Rattus norvegicus D-gluconate 6-phosphate + NADPH + H+ - r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Sus scrofa D-gluconate 6-phosphate + NADPH + H+ - ? 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Bos taurus D-gluconate 6-phosphate + NADPH + H+ - r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Aspergillus nidulans D-gluconate 6-phosphate + NADPH + H+ - r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Schizosaccharomyces pombe D-gluconate 6-phosphate + NADPH + H+ - ? 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Cryptococcus neoformans D-gluconate 6-phosphate + NADPH + H+ - ? 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Mus musculus D-gluconate 6-phosphate + NADPH + H+ glucono-delta-lactone-6-phosphate ? 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Bacillus subtilis D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Cyberlindnera jadinii D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Mus musculus D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Homo sapiens D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Bos taurus D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Geobacillus stearothermophilus D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Neurospora crassa D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Pisum sativum D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone ? 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Zea mays D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Pseudomonas fluorescens D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Pseudomonas sp. D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Trypanosoma brucei D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Dictyostelium discoideum D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone ? 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Dictyostelium discoideum D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone ir 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - [Candida] boidinii D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Agaricus bisporus D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone ? 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Penicillium duponti D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Aspergillus parasiticus D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Candida maltosa D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ sigmoidal relationship in cofactor binding Azotobacter vinelandii D-gluconate 6-phosphate + NADPH + H+ - r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ isoform A(-) shows sigmoidal enzyme-substrate interaction, isoform A(+) shows hyperbolic enzyme-substrate interaction Homo sapiens D-gluconate 6-phosphate + NADPH + H+ D-glucose-delta-lactone 6-phosphate r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ hyperbolic cofactor binding Homo sapiens D-gluconate 6-phosphate + NADPH + H+ - ? 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Pseudomonas sp. C D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Schizosaccharomyces pombe NCYC 132S2-2 D-gluconate 6-phosphate + NADPH + H+ - ? 188194 1.1.1.49 D-glucose 6-phosphate + H2O + NADP+ - Pseudomonas sp. W5 D-gluconate 6-phosphate + NADPH + H+ 6-phosphoglucono-delta-lactone r 188194 1.1.1.49 D-glucose 6-phosphate + NAD(P)+ - Thermotoga maritima D-glucono-1,5-lactone 6-phosphate + NAD(P)H - ? 370917 1.1.1.49 D-glucose 6-phosphate + NAD(P)+ key enzyme catalyzing the first step of the pentose phosphate pathway generating NADPH for anabolic metabolsim pathways and protection systems in the liver Canis lupus familiaris D-glucono-1,5-lactone 6-phosphate + NAD(P)H - ? 370917 1.1.1.49 D-glucose 6-phosphate + NAD+ - Bos taurus D-glucono-1,5-lactone 6-phosphate + NADH + H+ - ? 396879 1.1.1.49 D-glucose 6-phosphate + NAD+ - Pseudomonas fluorescens D-glucono-1,5-lactone 6-phosphate + NADH + H+ - ? 396879 1.1.1.49 D-glucose 6-phosphate + NAD+ - Thermotoga maritima D-glucono-1,5-lactone 6-phosphate + NADH + H+ - ? 396879 1.1.1.49 D-glucose 6-phosphate + NAD+ - Deinococcus radiophilus D-glucono-1,5-lactone 6-phosphate + NADH + H+ - ? 396879 1.1.1.49 D-glucose 6-phosphate + NAD+ - Taenia crassiceps D-glucono-1,5-lactone 6-phosphate + NADH + H+ - ? 396879 1.1.1.49 D-glucose 6-phosphate + NAD+ - Escherichia coli 6-phospho-D-glucono-1,5-lactone + NADH + H+ - ? 421938 1.1.1.49 D-glucose 6-phosphate + NAD+ NADP+-specific enzyme. In presence of NAD+ 410fold reduction in the performance of the enzyme Escherichia coli 6-phospho-D-glucono-1,5-lactone + NADH + H+ - ? 421938 1.1.1.49 D-glucose 6-phosphate + NAD+ very low activity with NAD+ Escherichia coli 6-phospho-D-glucono-1,5-lactone + NADH + H+ - ? 421938 1.1.1.49 D-glucose 6-phosphate + NAD+ - Escherichia coli K-10 6-phospho-D-glucono-1,5-lactone + NADH + H+ - ? 421938 1.1.1.49 D-glucose 6-phosphate + NAD+ - Escherichia coli DF82 6-phospho-D-glucono-1,5-lactone + NADH + H+ - ? 421938 1.1.1.49 D-glucose 6-phosphate + NADP+ - Meleagris gallopavo D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Brugia malayi D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Mus musculus D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Homo sapiens D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Rattus norvegicus D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Saccharomyces cerevisiae D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Ovis aries D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Hordeum vulgare D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Pisum sativum D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Solanum tuberosum D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Nicotiana tabacum D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Petroselinum crispum D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Priestia megaterium D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Pseudomonas fluorescens D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Pseudomonas aeruginosa D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Trypanosoma brucei D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Canis lupus familiaris D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Leuconostoc mesenteroides D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Meyerozyma guilliermondii D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Leishmania mexicana D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Oncorhynchus mykiss D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Thermotoga maritima D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Coriandrum sativum D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Deinococcus radiophilus D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Aquifex aeolicus D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Arabidopsis thaliana D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Polygonum cognatum D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Trypanosoma cruzi D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Koliella antarctica D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Camelus dromedarius D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ catalyzes the first step of the pentose phosphate pathway, enzyme deficiency often causes hemolytic anaemia Homo sapiens D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ differential regulation of isozymes, the cytosolic enzyme is regulated by sugar availability at transcriptional level, while the plastidic isozymes are regulated by redox mechanism Solanum tuberosum D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ enzyme catalyzes the first step of the pentose phosphate pathway Rattus norvegicus D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ involved in oxidative pentose phosphate pathway in roots, related to glutamate synthesis in the plastids Hordeum vulgare D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ key enzyme catalyzing the first step in the pentose phosphate pathway Homo sapiens D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ key enzyme catalyzing the first step of the hexose monophosphate shunt pathway Ovis aries D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ key enzyme of the pentose phosphate pathway Meleagris gallopavo D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ key regulatory enzyme of the pentose phosphate pathway, regulation mechanism study Rattus norvegicus D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ wild-type and mutant P409R Homo sapiens D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ oxidative enzyme of pentose phosphate pathway Pisum sativum D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ first step in the pentose phosphate pathway Oncorhynchus mykiss D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ G6PDH is the rate-limiting step in the formation of NADPH via the triphosphate, and is responsible for the major supply of NADPH in the cell Mus musculus D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ inhibition by divalent metal ions, at low NADPH /NADP+ ratio, is another means of controlling the pentose phosphate pathway Aspergillus aculeatus D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ the substrate specificity is extremely strict Aspergillus aculeatus D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ random bi bi sequential mechanism in rapid equilibrium Taenia crassiceps D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Pseudomonas aeruginosa P4 D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Arabidopsis thaliana T87 D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Meyerozyma guilliermondii FTI 20037 D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Pseudomonas fluorescens 13525 D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ - Trypanosoma brucei 427 D-glucono-1,5-lactone 6-phosphate + NADPH + H+ - ? 370918 1.1.1.49 D-glucose 6-phosphate + NADP+ assay at pH 7.4 Fragaria x ananassa NADPH + ? - ? 409150 1.1.1.49 D-glucose 6-phosphate + NADP+ - Mus musculus 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Escherichia coli 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Rattus norvegicus 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Saccharomyces cerevisiae 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Bos taurus 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Aspergillus niger 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - r 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Hordeum vulgare 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Pseudomonas fluorescens 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ir 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Corynebacterium glutamicum 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Meyerozyma guilliermondii 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Plasmodium falciparum 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Oryza sativa 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Camelus dromedarius 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Homo sapiens 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Trypanosoma cruzi 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Zymomonas mobilis subsp. mobilis 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ first enzyme of the pentose phosphate pathway, one of the main sources of NADPH Escherichia coli 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ oxidative pentose pathway Escherichia coli 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ the enzyme is involved pentose biosynthesis Escherichia coli 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ NADP+-specific enzyme. In presence of NAD+ 410fold reduction in the performance of the enzyme. Modeling of the sensitivity of reduced cofactor production by G6PDH as a function of the redox ratios of NAD/NADH (rRNAD) and NADP/NADPH (rRNADP). NADPH production sharply increases within the range of thermodynamically feasible values of rRNADP, but NADH production remains low within the range feasible for rRNAD Escherichia coli 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Meyerozyma guilliermondii ATCC 201935 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Saccharomyces cerevisiae YPH250 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Pseudomonas fluorescens NCIMB 10525 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ir 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Escherichia coli B / ATCC 11303 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ oxidative pentose pathway Escherichia coli B / ATCC 11303 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ the enzyme is involved pentose biosynthesis Escherichia coli B / ATCC 11303 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Zymomonas mobilis subsp. mobilis NRRL B-12526 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Corynebacterium glutamicum JHI3-156 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Escherichia coli K-10 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ - Escherichia coli DF82 6-phospho-D-glucono-1,5-lactone + NADPH + H+ - ? 421939 1.1.1.49 D-glucose 6-phosphate + NADP+ + H2O - Saccharomyces cerevisiae D-gluconate 6-phosphate + NADPH + H+ - ? 386428 1.1.1.49 D-glucose 6-phosphate + NADP+ + H2O - Ovis aries D-gluconate 6-phosphate + NADPH + H+ - ? 386428 1.1.1.49 D-glucose 6-phosphate + NADP+ + H2O - Trypanosoma cruzi D-gluconate 6-phosphate + NADPH + H+ - ? 386428 1.1.1.49 D-glucose 6-phosphate + NADP+ + H2O the enzyme is responsible for the production of NADPH, which is required for biosynthetic reactions and protection of cells from free radicals Ovis aries D-gluconate 6-phosphate + NADPH + H+ - ? 386428 1.1.1.49 D-glucose 6-phosphate + NADP+ + H2O - Saccharomyces cerevisiae W303-181 D-gluconate 6-phosphate + NADPH + H+ - ? 386428 1.1.1.49 D-glucose 6-phosphate + thio-NAD(P)+ the thio-cofactors give increased activity compared to the non-thio-cofactors Thermotoga maritima D-glucono-1,5-lactone 6-phosphate + thio-NAD(P)H - ? 372909 1.1.1.49 D-glucose 6-phosphate + thio-NAD+ - Thermotoga maritima 6-phospho-D-glucono-1,5-lactone + thio-NADH + H+ - r 451063 1.1.1.49 additional information both isoenzymes show no activity with glucose and NAD+, isoenzyme I shows no activity with 6-phosphonogluconate Homo sapiens ? - ? 89 1.1.1.49 additional information both isoenzymes show no activity with glucose and NAD+, isoenzyme I shows no activity with 6-phosphonogluconate Sus scrofa ? - ? 89 1.1.1.49 additional information no activity with glucose, glucose 1-phosphate, 2-deoxyglucose 6-phosphate, fructose, fructose 6-phosphate, fructose 1,6-diphosphate, mannose, galactose 6-phosphate, NAD+ Aspergillus nidulans ? - ? 89 1.1.1.49 additional information no activity with glucose, glucose 1-phosphate, 2-deoxyglucose 6-phosphate, fructose, fructose 6-phosphate, fructose 1,6-diphosphate, mannose, galactose 6-phosphate, NAD+ Aspergillus niger ? - ? 89 1.1.1.49 additional information no activity with D-glucose, D-ribose, D-fructose-6-phosphate, D-ribose-5-phosphate Schizosaccharomyces pombe ? - ? 89 1.1.1.49 additional information physiological regulation of NADP+-NADPH-ratio in the brain is dicussed Rattus norvegicus ? - ? 89 1.1.1.49 additional information no activity with glucose and glucosamine 6-phosphate Aspergillus aculeatus ? - ? 89 1.1.1.49 additional information glucose-6-phosphate dehydrogenase protects the parasite against reactive oxygen species Trypanosoma cruzi ? - ? 89 1.1.1.49 additional information G6PD overexpressed in adipocytes in obese (including db/db, ob/ob and diet-induced obesity) mice, in adipocytes and stromal-vascular cells in diabetic db/db mice, and in adipocytes cultured under high-glucose conditions in vitro induces the expression of NADPH oxidase and leads to an increase in oxidative stress Mus musculus ? - ? 89 1.1.1.49 additional information G6PDH plays a critical role in maintaining cellular reduced glutathione levels under long-term salt stress in plants. NADPH, produced by G6PDH, not only acts as the reducing potential for the output of reduced glutathione, but is involved in the activity of plasma membrane NADPH oxidase under salt stress, which results in hydrogen peroxide accumulation Phragmites australis ? - ? 89 1.1.1.49 additional information G6PDH plays a role in supplying NADPH for oil accumulation in developing seeds in which photosynthesis may be light limited Arabidopsis thaliana ? - ? 89 1.1.1.49 additional information transgenic (previously susceptible) lines overexpressing G6PDH-encoding gene, displaying high NADPH tolerance engineered for cytosolic expression, show early oxidative bursts, callose deposition, and changes in metabolic parameter Nicotiana tabacum ? - ? 89 1.1.1.49 additional information no activity with other sugars, such as fructose-6-phosphate, glucose-1-phosphate, ribulose 5-phosphate, and ribose 5-phosphate Leuconostoc mesenteroides ? - ? 89 1.1.1.49 additional information the following substances, 1 mM, are not substrates when substituted for D-glucose 6-phosphate: D-glucose 6-phosphate, D-fructose 1-phosphate, D-gluconate 6-phosphate, D-galactose 6-phosphate, D-ribose 5-phosphate, and D-glucose Escherichia coli ? - ? 89 1.1.1.49 additional information the enzyme is a bifunctional enzyme glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, the enzyme activity is analyzed for the reaction of glucose-6-phosphate dehydrogenase, EC 1.1.1.49, in a coupled assay with diaphorase activity, which uses NADPH to reduce resazurin to form the highly fluorescent molecule resorufin Plasmodium falciparum ? - ? 89 1.1.1.49 additional information no activity with D-glucose, D-ribose, D-fructose-6-phosphate, D-ribose-5-phosphate Schizosaccharomyces pombe NCYC 132S2-2 ? - ? 89 1.1.1.49 additional information the following substances, 1 mM, are not substrates when substituted for D-glucose 6-phosphate: D-glucose 6-phosphate, D-fructose 1-phosphate, D-gluconate 6-phosphate, D-galactose 6-phosphate, D-ribose 5-phosphate, and D-glucose Escherichia coli K-10 ? - ? 89 1.1.1.49 additional information the following substances, 1 mM, are not substrates when substituted for D-glucose 6-phosphate: D-glucose 6-phosphate, D-fructose 1-phosphate, D-gluconate 6-phosphate, D-galactose 6-phosphate, D-ribose 5-phosphate, and D-glucose Escherichia coli DF82 ? - ? 89