1.1.1.271	GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADH + H+	-	Escherichia coli	GDP-beta-L-fucose + NAD+	-	r	426417	
1.1.1.271	GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADH + H+	-	Sus scrofa	GDP-beta-L-fucose + NAD+	-	r	426417	
1.1.1.271	GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADH + H+	the enzyme synthesizes GDP-L-fucose from its substrate GDP-4-keto-6-deoxy-D-mannose. The reaction involves epimerization at both C-3 and C-5 followed by an NADPH-dependent reduction of the carbonyl at C-4	Mortierella alpina	GDP-beta-L-fucose + NAD+	product identification by capillary electrophoresis, electro-spray ionization-mass spectrometry, and nuclear magnetic resonance spectroscopy	?	426417	
1.1.1.271	GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH + H+	-	Mortierella alpina	GDP-beta-L-fucose + NADP+	-	?	424810	
1.1.1.271	GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH + H+	the enzyme synthesizes GDP-L-fucose from its substrate GDP-4-keto-6-deoxy-D-mannose. The reaction involves epimerization at both C-3 and C-5 followed by an NADPH-dependent reduction of the carbonyl at C-4	Homo sapiens	GDP-beta-L-fucose + NADP+	-	?	424810	
1.1.1.271	GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH + H+	the enzyme synthesizes GDP-L-fucose from its substrate GDP-4-keto-6-deoxy-D-mannose. The reaction involves epimerization at both C-3 and C-5 followed by an NADPH-dependent reduction of the carbonyl at C-4	Mortierella alpina	GDP-beta-L-fucose + NADP+	product identification by capillary electrophoresis, electro-spray ionization-mass spectrometry, and nuclear magnetic resonance spectroscopy	?	424810	
1.1.1.271	GDP-4-dehydro-6-deoxy-D-mannose + NADPH	-	Mycobacterium tuberculosis	GDP-L-fucose + NADP+	-	r	394861	
1.1.1.271	GDP-4-dehydro-6-deoxy-D-mannose + NADPH	-	Escherichia coli K-12	GDP-L-fucose + NADP+	-	r	394861	
1.1.1.271	GDP-4-dehydro-6-deoxy-D-mannose + NADPH	the enzyme is crucial in the biosynthesis of GDP-L-fucose together with GDP-D-mannose-4,6-dehydratase, overview	Escherichia coli K-12	GDP-L-fucose + NADP+	-	r	394861	
1.1.1.271	GDP-4-dehydro-6-deoxy-D-mannose + NADPH	the enzyme is required for the formation of activated L-fucose	Mycobacterium tuberculosis	GDP-L-fucose + NADP+	-	r	394861	
1.1.1.271	GDP-4-dehydro-alpha-D-rhamnose + NADPH + H+	-	Escherichia coli	GDP-beta-L-fucose + NADP+	-	?	439538	
1.1.1.271	GDP-4-dehydro-alpha-D-rhamnose + NADPH + H+	-	Plasmodium falciparum	GDP-beta-L-fucose + NADP+	-	?	439538	
1.1.1.271	GDP-4-dehydro-alpha-D-rhamnose + NADPH + H+	-	Homo sapiens	GDP-beta-L-fucose + NADP+	-	?	439538	
1.1.1.271	GDP-4-dehydro-alpha-D-rhamnose + NADPH + H+	-	Escherichia coli K12	GDP-beta-L-fucose + NADP+	-	?	439538	
1.1.1.271	GDP-4-keto-6-deoxy-D-mannose + NADPH	-	Mus musculus	GDP-6-deoxy-L-galactose + NADP+	-	?	257195	
1.1.1.271	GDP-4-keto-6-deoxy-D-mannose + NADPH	-	Escherichia coli	GDP-6-deoxy-L-galactose + NADP+	-	?	257195	
1.1.1.271	GDP-4-keto-6-deoxy-D-mannose + NADPH	-	Homo sapiens	GDP-6-deoxy-L-galactose + NADP+	-	?	257195	
1.1.1.271	GDP-4-keto-6-deoxy-D-mannose + NADPH	-	Rattus norvegicus	GDP-6-deoxy-L-galactose + NADP+	-	?	257195	
1.1.1.271	GDP-4-keto-6-deoxy-D-mannose + NADPH	-	Helicobacter pylori	GDP-6-deoxy-L-galactose + NADP+	-	?	257195	
1.1.1.271	GDP-4-keto-6-deoxy-D-mannose + NADPH	-	Caenorhabditis elegans	GDP-6-deoxy-L-galactose + NADP+	-	?	257195	
1.1.1.271	GDP-4-keto-6-deoxy-D-mannose + NADPH	-	Drosophila melanogaster	GDP-6-deoxy-L-galactose + NADP+	-	?	257195	
1.1.1.271	GDP-4-keto-6-deoxy-D-mannose + NADPH	enzyme uses NADH as cofactor	Sus scrofa	GDP-6-deoxy-L-galactose + NADP+	-	?	257195	
1.1.1.271	GDP-4-keto-6-deoxy-D-mannose + NADPH	catalyzes the stereospecific hydride transfer of the ProS hydrogen from NADPH to carbon 4 of the mannose sugar	Escherichia coli	GDP-6-deoxy-L-galactose + NADP+	-	?	257195	
1.1.1.271	GDP-4-keto-6-deoxy-D-mannose + NADPH	bifunctional enzyme that exhibits epimerase and reductase activity: 3,5-epimerization to GDP-4-keto-6-deoxy-L-galactose and subsequent NADPH-dependent reduction to GDP-L-fucose	Arabidopsis thaliana	GDP-6-deoxy-L-galactose + NADP+	-	?	257195	
1.1.1.271	GDP-4-keto-6-deoxy-D-mannose + NADPH	enzyme also utilizes NADH but with lower affinity	Escherichia coli	GDP-6-deoxy-L-galactose + NADP+	-	?	257195	
1.1.1.271	GDP-4-keto-6-deoxy-D-mannose + NADPH	catalyzes the last two steps in the de novo synthesis of L-fucose	Arabidopsis thaliana	GDP-6-deoxy-L-galactose + NADP+	-	?	257195	
1.1.1.271	GDP-4-keto-6-deoxy-D-mannose + NADPH	-	Helicobacter pylori NTC 11637	GDP-6-deoxy-L-galactose + NADP+	-	?	257195	
1.1.1.271	GDP-4-keto-6-deoxy-D-mannose + NADPH + H+	-	Escherichia coli K-12	GDP-L-fucose + NADP+	-	?	405231	
1.1.1.271	GDP-4-keto-6-deoxy-D-mannose + NADPH + H+	-	Escherichia coli	GDP-L-fucose + NADP+	-	?	405231	
1.1.1.271	additional information	fucosylation is regulated by complicated mechanisms that involve several factors: fucosyltransferases, GDP-fucose transporter, and GDP-fucose-synthetic enzymes, such as GDP-mannose 4,6-dehydratase, GDP-4-keto-6-deoxy-mannose-3,5-epimerase-4-reductase, and GDP-fucose pyrophosphorylase, fucose metabolism, overview	Homo sapiens	?	-	?	89