1.1.1.105 11-cis-retinol + NAD+ - Mus musculus 11-cis-retinal + NADH + H+ - r 383590 1.1.1.105 11-cis-retinol + NAD+ - Mus musculus C57BL/6J 11-cis-retinal + NADH + H+ - r 383590 1.1.1.105 11-cis-retinol + NAD+ - Homo sapiens ? - ? 438655 1.1.1.105 13-cis-retinol + NAD+ - Homo sapiens 13-cis-retinal + NADH + H+ - ? 398629 1.1.1.105 13-cis-retinol + NAD+ RoDH-4 can potentially contribute to the biosynthesis of two powerful modulators of gene expression: retinoic acid from retinol and dihydrotestosterone from 3alpha-androstane-diol Homo sapiens 13-cis-retinal + NADH + H+ - ? 398629 1.1.1.105 3,4-didehydroretinol + NAD+ 60% of the efficiency against all-trans-retinol Homo sapiens 3,4-didehydroretinal + NADH - ? 371792 1.1.1.105 5alpha-androstan-3alpha-ol-17-one + NAD+ - Homo sapiens ? + NADH - ? 372142 1.1.1.105 9-cis-retinol + NAD+ higher activity with all-trans-retinol versus 9-cis-retinol Mus musculus 9-cis-retinal + NADH + H+ - ? 384017 1.1.1.105 all-trans retinal + NADH + H+ - Homo sapiens all-trans-retinol + NAD+ - r 396363 1.1.1.105 all-trans retinal + NADH + H+ oxidative activity is below the detection limit Branchiostoma floridae all-trans-retinol + NAD+ - r 396363 1.1.1.105 all-trans retinal + NADH + H+ 26.8% of the activity with butan-1-ol Kangiella koreensis all-trans retinol + NAD+ - ? 437004 1.1.1.105 all-trans-retinal + NAD(P)H + H+ - Mus musculus all-trans-retinol + NAD(P)+ - ? 188555 1.1.1.105 all-trans-retinal + NAD(P)H + H+ RDH5 has only a minor in vivo all-trans RDH activity Mus musculus all-trans-retinol + NAD(P)+ - ? 188555 1.1.1.105 all-trans-retinal + NAD+ catalytic efficiency in the reductive direction is lower than in the oxidative direction Mus musculus all-trans-retinol + NADH + H+ - r 459174 1.1.1.105 all-trans-retinal + NAD+ catalytic efficiency in the reductive direction is lower than in the oxidative direction Mus musculus C57BL/6J all-trans-retinol + NADH + H+ - r 459174 1.1.1.105 all-trans-retinal + NADH + H+ - Homo sapiens all-trans-retinol + NAD+ - ? 186930 1.1.1.105 all-trans-retinal + NADH + H+ - Homo sapiens all-trans-retinol + NAD+ - r 186930 1.1.1.105 all-trans-retinal + NADH + H+ - Kangiella koreensis all-trans-retinol + NAD+ - r 186930 1.1.1.105 all-trans-retinal + NADH + H+ - Mus musculus all-trans-retinol + NAD+ - r 186930 1.1.1.105 all-trans-retinal + NADH + H+ wild type RDH10 catalyzes both oxidation of all-trans retinol and reduction of all-trans retinal in vitro. On cultured cells, however, oxidation is the favored reaction catalyzed by RDH10. Homo sapiens all-trans-retinol + NAD+ - ? 186930 1.1.1.105 all-trans-retinal + NADH + H+ 26% activity compared to butyl alcohol Kangiella koreensis all-trans-retinol + NAD+ - r 186930 1.1.1.105 all-trans-retinal + NADH + H+ catalytic efficiency in the reductive direction is lower than in the oxidative direction Mus musculus all-trans-retinol + NAD+ - r 186930 1.1.1.105 all-trans-retinal + NADH + H+ - Kangiella koreensis SW-125 all-trans-retinol + NAD+ - r 186930 1.1.1.105 all-trans-retinal + NADH + H+ 26% activity compared to butyl alcohol Kangiella koreensis SW-125 all-trans-retinol + NAD+ - r 186930 1.1.1.105 all-trans-retinal + NADH + H+ - Mus musculus C57BL/6J all-trans-retinol + NAD+ - r 186930 1.1.1.105 all-trans-retinal + NADH + H+ catalytic efficiency in the reductive direction is lower than in the oxidative direction Mus musculus C57BL/6J all-trans-retinol + NAD+ - r 186930 1.1.1.105 all-trans-retinal-[cellular-retinol-binding-protein] + NADPH + H+ - Homo sapiens all-trans-retinol-[cellular-retinol-binding-protein] + NADP+ - ? 450913 1.1.1.105 all-trans-retinaldehyde + NADH + H+ - Homo sapiens ? - ? 404270 1.1.1.105 all-trans-retinaldehyde + NADH + H+ - Homo sapiens all-trans-retinol + NAD+ - r 439101 1.1.1.105 all-trans-retinol + NAD+ - Homo sapiens all-trans-retinal + NADH - ? 186926 1.1.1.105 all-trans-retinol + NAD+ RoDH-4 is capable of contributing to the oxidation of retinol to retinaldehyde for retinoic acid biosynthesis in the cellular context Homo sapiens all-trans-retinal + NADH - ? 186926 1.1.1.105 all-trans-retinol + NAD+ in intact cells, the enzyme functions as retinol dehydrogenase, and contributes to the oxidation of retinol, but not to the reduction of retinaldehyde Ciona intestinalis all-trans-retinal + NADH - ir 186926 1.1.1.105 all-trans-retinol + NAD+ in intact cells, the enzyme functions as retinol dehydrogenase, and contributes to the oxidation of retinol, but not to the reduction of retinaldehyde Lytechinus variegatus all-trans-retinal + NADH - ir 186926 1.1.1.105 all-trans-retinol + NAD+ - Homo sapiens all-trans-retinal + NADH + H+ - r 384149 1.1.1.105 all-trans-retinol + NAD+ - Homo sapiens all-trans-retinal + NADH + H+ - ? 384149 1.1.1.105 all-trans-retinol + NAD+ - Drosophila melanogaster all-trans-retinal + NADH + H+ - ? 384149 1.1.1.105 all-trans-retinol + NAD+ - Kangiella koreensis all-trans-retinal + NADH + H+ - r 384149 1.1.1.105 all-trans-retinol + NAD+ - Mus musculus all-trans-retinal + NADH + H+ - r 384149 1.1.1.105 all-trans-retinol + NAD+ exhibits a strong preference for NAD+/NADH as cofactors. Activity toward all-trans-retinal in the presence of NADH is 2fold lower than activity with all-trans-retinol and NAD+. The preference for NAD+ suggests that RDH-E2 is likely to function in the oxidative direction in vivo, further supporting its potential role in the oxidation of retinol to retinaldehyde for retinoic acid biosynthesis in human keratinocytes Homo sapiens all-trans-retinal + NADH + H+ - r 384149 1.1.1.105 all-trans-retinol + NAD+ RDH1 functions in a path of all-trans-retinoic acid biosynthesis starting early during embryogenesis Mus musculus all-trans-retinal + NADH + H+ - ? 384149 1.1.1.105 all-trans-retinol + NAD+ RoDH-4 can potentially contribute to the biosynthesis of two powerful modulators of gene expression: retinoic acid from retinol and dihydrotestosterone from 3alpha-androstane-diol Homo sapiens all-trans-retinal + NADH + H+ - ? 384149 1.1.1.105 all-trans-retinol + NAD+ exhibits a strong preference for NAD+/NADH as cofactors. Activity with NAD+ is about 10fold higher than activity in presence of NADP+. Activity toward all-trans-retinal in the presence of NADH is 2fold lower than activity with all-trans-retinol and NAD+ Homo sapiens all-trans-retinal + NADH + H+ - r 384149 1.1.1.105 all-trans-retinol + NAD+ RDH1 has 8–11fold higher activity with NAD+ versus NADP+. Higher activity with all-trans-retinol versus 9-cis-retinol. Multifunctional enzyme. In addition to retinol dehydrogenase activity, RDH1 has strong 3alpha-hydroxy and weak 17beta-hydroxy steroid dehydrogenase activities Mus musculus all-trans-retinal + NADH + H+ - ? 384149 1.1.1.105 all-trans-retinol + NAD+ 30.2% activity compared to butyl alcohol Kangiella koreensis all-trans-retinal + NADH + H+ - ? 384149 1.1.1.105 all-trans-retinol + NAD+ - Kangiella koreensis SW-125 all-trans-retinal + NADH + H+ - r 384149 1.1.1.105 all-trans-retinol + NAD+ 30.2% activity compared to butyl alcohol Kangiella koreensis SW-125 all-trans-retinal + NADH + H+ - ? 384149 1.1.1.105 all-trans-retinol + NAD+ - Mus musculus C57BL/6J all-trans-retinal + NADH + H+ - r 384149 1.1.1.105 all-trans-retinol + NAD+ - Homo sapiens all-trans-retinaldehyde + NADH + H+ - r 439102 1.1.1.105 all-trans-retinol + NADP+ exhibits a strong preference for NAD+/NADH as cofactors. Activity with NAD+ is about 10fold higher than activity in presence of NADP+ Homo sapiens all-trans-retinal + NADPH + H+ - r 370852 1.1.1.105 all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ - Mus musculus all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+ - ? 421843 1.1.1.105 all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ - Mus musculus all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+ - ir 421843 1.1.1.105 all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ - Homo sapiens all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+ - ir 421843 1.1.1.105 all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ - Rattus norvegicus all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+ - ir 421843 1.1.1.105 all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ RDH interact with/or recognize holo-CRBP1 Homo sapiens all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+ - ir 421843 1.1.1.105 all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ RDH interact with/or recognize holo-CRBP1 Rattus norvegicus all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+ - ir 421843 1.1.1.105 all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ RDH interact with/or recognize holo-CRBP1, except for RDH10 that does not access holo-CRBP1 as substrate Mus musculus all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+ - ir 421843 1.1.1.105 all-trans-retinol-[cellular-retinol-binding-protein] + NAD+ - Mus musculus C57BL/6 x 129/Sv all-trans-retinal-[cellular-retinol-binding-protein] + NADH + H+ - ? 421843 1.1.1.105 all-trans-retinol-[cellular-retinol-binding-protein] + NADP+ - Homo sapiens all-trans-retinal-[cellular-retinol-binding-protein] + NADPH + H+ - r 450912 1.1.1.105 androsterone + NAD+ - Homo sapiens ? + NADH - ? 372394 1.1.1.105 butyl alcohol + NAD+ 100% activity Kangiella koreensis butanal + NADH + H+ - ? 439277 1.1.1.105 butyl alcohol + NAD+ 100% activity Kangiella koreensis SW-125 butanal + NADH + H+ - ? 439277 1.1.1.105 additional information the enzyme is expressed predominantly in the differentiating spinous layers and is under positive, feed-forward regulation by retinoic acid Homo sapiens ? - ? 89 1.1.1.105 additional information chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition Rattus norvegicus ? - ? 89 1.1.1.105 additional information chronic ethanol consumption results in an increased activity of the microsomal retinol dehydrogenase which may contribute to hepatic retinol depletion, especially in the view of the insensitivity of the enzyme to ethanol inhibition Peromyscus maniculatus ? - ? 89 1.1.1.105 additional information substrate bound to cellular retinol binding protein is preferred Homo sapiens ? - ? 89 1.1.1.105 additional information negligible activity with 9-cis-retinol Branchiostoma floridae ? - ? 89 1.1.1.105 additional information no activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD+/NADH or NADP+/NADPH Homo sapiens ? - ? 89 1.1.1.105 additional information RoDH-4 belongs to the group of short-chain dehydrogenase/reductases that are active toward two types of substrates, retinoids and 3alpha-hydroxysteroids Homo sapiens ? - ? 89 1.1.1.105 additional information the enzymes utilizes retinol bound to cellular retinol binding protein type I at a much lower rate than free retinol Homo sapiens ? - ? 89 1.1.1.105 additional information the multifunctional enzyme oxidizes the 3alpha-hydroxysteroids androstane-diol and androsterone to dihydrotestosterone and androstanedione, respectively Homo sapiens ? - ? 89 1.1.1.105 additional information NAD+-dependent retinoid-active SDRs have higher catalytic efficiencies for the oxidation of 3alpha-hydroxysterols than of retinols Homo sapiens ? - ? 89 1.1.1.105 additional information RDH-E2 may be involved in the pathogenesis of psoriasis through its potential role in retinoic acid biosynthesis and stimulation of keratinocyte proliferation Homo sapiens ? - ? 89 1.1.1.105 additional information RDH10 is required for proper retinoic acid signalling in the early embryo, RDH10 cooperates with retinal dehydrogenase 2 during axis development and central nervous system patterning Xenopus laevis ? - ? 89 1.1.1.105 additional information no activity is detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD+/NADH or NADP+/NADPH Homo sapiens ? - ? 89 1.1.1.105 additional information no activity with decanal Mus musculus ? - ? 89 1.1.1.105 additional information enzyme is an alcohol dehydrogenase, EC 1.1.1.1, with activity for all-trans-retinol using NAD+ as a cofactor Kangiella koreensis ? - ? 89 1.1.1.105 additional information the enzyme is not active with NADP+ or NADPH as cofactors Homo sapiens ? - ? 89 1.1.1.105 additional information in addition to all-trans-retinol, RDHE2S recognizes 11-cis-retinol as substrate Mus musculus ? - - 89 1.1.1.105 additional information no activity toward all-trans-retinol is detected using the microsomal and mitochondrial preparations of recombinant murine RDHE2 protein expressed in Spodoptera frugiperda Sf9 cells. But although inactive toward retinol in isolated microsomes, RDHE2 is able to function as a retinol dehydrogenase in intact cells Mus musculus ? - - 89 1.1.1.105 additional information no activity with decanal Mus musculus C57BL/6 x 129/Sv ? - ? 89 1.1.1.105 additional information in addition to all-trans-retinol, RDHE2S recognizes 11-cis-retinol as substrate Mus musculus C57BL/6J ? - - 89 1.1.1.105 additional information no activity toward all-trans-retinol is detected using the microsomal and mitochondrial preparations of recombinant murine RDHE2 protein expressed in Spodoptera frugiperda Sf9 cells. But although inactive toward retinol in isolated microsomes, RDHE2 is able to function as a retinol dehydrogenase in intact cells Mus musculus C57BL/6J ? - - 89 1.1.1.105 retinal + NAD(P)H - Gallus gallus retinol + NAD(P)+ - ir 188554 1.1.1.105 retinal + NADH - Mus musculus retinol + NAD+ - ? 186976 1.1.1.105 retinal + NADH - Rattus norvegicus retinol + NAD+ - r 186976 1.1.1.105 retinal + NADH - Peromyscus maniculatus retinol + NAD+ - r 186976 1.1.1.105 retinal + NADH + H+ - Xenopus laevis retinol + NAD+ - r 406573 1.1.1.105 retinal + NADPH + H+ - Rattus norvegicus retinol + NADP+ - ? 186977 1.1.1.105 retinal + NADPH + H+ activity is lower than with NADH Rattus norvegicus retinol + NADP+ - ? 186977 1.1.1.105 retinol + NAD+ - Homo sapiens retinal + NADH - ? 186968 1.1.1.105 retinol + NAD+ - Rattus norvegicus retinal + NADH - ? 186968 1.1.1.105 retinol + NAD+ - Rattus norvegicus retinal + NADH - r 186968 1.1.1.105 retinol + NADP+ - Peromyscus maniculatus retinal + NADPH - ? 186975 1.1.1.105 retinol bound to cellular retinol binding protein + NAD+ - Homo sapiens retinal bound to cellular retinol binding protein + NADH - ? 374560