2.7.6.2 thiamine + ATP - thiamine diphosphate + AMP - ? 386714 2.7.6.2 thiamine + ATP TPP plays a critical role in the carbohydrate and energy metabolism. It functions as a prosthetic group for the mitochondrial enzyme complexes like pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and branched chain alpha-keto acid dehydrogenase. In addition, TPP is involved in the cytosolic pentose pathway functioning as coenzyme for transketolase. thiamine diphosphate + AMP - ? 386714 2.7.6.2 UTP + thiamine - UMP + thiamine diphosphate - ? 358311 2.7.6.2 UTP + thiamine 207% of the activity with ATP UMP + thiamine diphosphate - ? 358311