2.1.1.67 additional information aliphatic thiol compounds are poor substrates or not methylated, dithiothreitol is no substrate ? - ? 89 2.1.1.67 additional information glutathione is no substrate ? - ? 89 2.1.1.67 additional information S-adenosyl-L-methionine and sinefungin prevent degradation of TPMT by stabilizing ist native structure ? - ? 89 2.1.1.67 S-(5'-adenosyl)-L-methionine-d3 disulfate salt + 6-mercaptopurine - S-adenosyl-L-homocysteine + 6-(d3-methyl)mercaptopurine - ? 456351 2.1.1.67 S-adenosyl-L-methionine + 2,8-dihydroxy-6-thiopurine - S-adenosyl-L-homocysteine + 2,8-dihydroxy-6-methylthiopurine - ? 319802 2.1.1.67 S-adenosyl-L-methionine + 2-amino-6-thiopurine - S-adenosyl-L-homocysteine + 2-amino-6-methylthiopurine - ? 319801 2.1.1.67 S-adenosyl-L-methionine + 2-aminothiophenol - S-adenosyl-L-homocysteine + 2-methylsulfanylphenylamine - ? 319806 2.1.1.67 S-adenosyl-L-methionine + 2-bromothiophenol - S-adenosyl-L-homocysteine + 1-bromo-2-methylsulfanylbenzene - ? 319803 2.1.1.67 S-adenosyl-L-methionine + 2-mercaptoethanol - S-adenosyl-L-homocysteine + 2-methylmercaptoethanol - ? 319832 2.1.1.67 S-adenosyl-L-methionine + 2-methoxythiophenol - S-adenosyl-L-homocysteine + 1-methoxy-2-methylsulfanylbenzene - ? 319807 2.1.1.67 S-adenosyl-L-methionine + 2-thiothymine - S-adenosyl-L-homocysteine + 2-methylthiothymine - ? 319795 2.1.1.67 S-adenosyl-L-methionine + 2-thiouracil - S-adenosyl-L-homocysteine + thiouracil-2-S-methylether - ? 319793 2.1.1.67 S-adenosyl-L-methionine + 3-methoxythiophenol - S-adenosyl-L-homocysteine + 1-methylsulfanyl-3-methoxybenzene - ? 319805 2.1.1.67 S-adenosyl-L-methionine + 4-(aminomethoxy)thiophenol - S-adenosyl-L-homocysteine + 1-aminomethoxy-4-methylsulfanylbenzene - ? 319804 2.1.1.67 S-adenosyl-L-methionine + 4-bromothiophenol - S-adenosyl-L-homocysteine + 1-bromo-4-methylsulfanylbenzene - ? 319810 2.1.1.67 S-adenosyl-L-methionine + 4-chlorothiophenol - S-adenosyl-L-homocysteine + 1-chloro-4-methylsulfanylbenzene - ? 319809 2.1.1.67 S-adenosyl-L-methionine + 4-fluorothiophenol - S-adenosyl-L-homocysteine + 1-fluoro-4-methylsulfanylbenzene - ? 319811 2.1.1.67 S-adenosyl-L-methionine + 4-methoxythiophenol - S-adenosyl-L-homocysteine + 1-methoxy-4-methylsulfanylbenzene - ? 319808 2.1.1.67 S-adenosyl-L-methionine + 4-methylthiophenol - S-adenosyl-L-homocysteine + 1-methyl-4-methylsulfanylbenzene - ? 319812 2.1.1.67 S-adenosyl-L-methionine + 4-nitrothiophenol - S-adenosyl-L-homocysteine + 1-methylsulfanyl-4-nitrobenzene - ? 319813 2.1.1.67 S-adenosyl-L-methionine + 4-thiobenzoate - S-adenosyl-L-homocysteine + 4-methylsulfanyl benzoate - ? 319814 2.1.1.67 S-adenosyl-L-methionine + 6-hydroxy-8-mercaptopurine - S-adenosyl-L-homocysteine + 6-hydroxy-8-methylmercaptopurine - ? 319821 2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine - S-adenosyl-L-homocysteine + 6-methylmercaptopurine - ? 319815 2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine immunosuppressant medication S-adenosyl-L-homocysteine + 6-methylmercaptopurine - ? 319815 2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine inactivation S-adenosyl-L-homocysteine + 6-methylmercaptopurine - ? 319815 2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT S-adenosyl-L-homocysteine + 6-methylmercaptopurine - ? 319815 2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine TPMT deactivates 6-mercaptopurine by methylation S-adenosyl-L-homocysteine + 6-methylmercaptopurine - ? 319815 2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine - ? - ? 398268 2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine - S-adenosyl-L-homocysteine + 6-methylmercaptopurine-d3 - ? 474106 2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine nucleoside inactivation S-adenosyl-L-homocysteine + 6-methylmercaptopurine nucleoside - ? 398267 2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine-riboside - S-adenosyl-L-homocysteine + 6-methylmercaptopurine-riboside - ? 319817 2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine-riboside-5'-monophosphate - S-adenosyl-L-homocysteine + 6-methylmercaptopurine-riboside-5'-monophosphate - ? 319818 2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine-riboside-5'-triphosphate - S-adenosyl-L-homocysteine + 6-methylmercaptopurine-riboside-5'-triphosphate - ? 319819 2.1.1.67 S-adenosyl-L-methionine + 6-selenoguanine-riboside - S-adenosyl-L-homocysteine + 6-methylselenoguanine-riboside - ? 319825 2.1.1.67 S-adenosyl-L-methionine + 6-selenopurine - S-adenosyl-L-homocysteine + 6-methylselenopurine - ? 319823 2.1.1.67 S-adenosyl-L-methionine + 6-selenopurine-riboside - S-adenosyl-L-homocysteine + 6-methylselenopurine-riboside - ? 319824 2.1.1.67 S-adenosyl-L-methionine + 6-thiodeoxyguanosine - S-adenosyl-L-homocysteine + 6-thiodeoxyguanosine S-methylether - r 451887 2.1.1.67 S-adenosyl-L-methionine + 6-thiodeoxyguanosine monophosphate - S-adenosyl-L-homocysteine + 6-methylthiodeoxyguanosine monophosphate - ? 319831 2.1.1.67 S-adenosyl-L-methionine + 6-thiodeoxyinosine - S-adenosyl-L-homocysteine + 6-thiodeoxyinosine S-methylether - r 451888 2.1.1.67 S-adenosyl-L-methionine + 6-thiodeoxyinosine monophosphate - S-adenosyl-L-homocysteine + 6-methyl thiodeoxyinosine monophosphate - ? 319830 2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine - S-adenosyl-L-homocysteine + 6-methylthioguanine - ? 319796 2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine - ? - ? 398270 2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine monophosphate - S-adenosyl-L-homocysteine + 6-methylthioguanine monophosphate - ? 398269 2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine-riboside - S-adenosyl-L-homocysteine + 6-methylthioguanine-riboside - ? 319798 2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine-riboside-5'-monophosphate - S-adenosyl-L-homocysteine + 6-methylthioguanine-riboside-5'-monophosphate - ? 319799 2.1.1.67 S-adenosyl-L-methionine + 6-thioguanosine monophosphate - S-adenosyl-L-homocysteine + 6-methyl thioguanosine monophosphate - ? 319829 2.1.1.67 S-adenosyl-L-methionine + 6-thioinosine - S-adenosyl-L-homocysteine + 6-methylmercaptopurine riboside - ? 398274 2.1.1.67 S-adenosyl-L-methionine + 6-thioinosine 5'-monophosphate - S-adenosyl-L-homocysteine + 6-methylmercaptopurine ribonucleotide - ? 398271 2.1.1.67 S-adenosyl-L-methionine + 6-thioinosine diphosphate - S-adenosyl-L-homocysteine + 6-methylthioinosine diphosphate - ? 456395 2.1.1.67 S-adenosyl-L-methionine + 6-thioinosine monophosphate - S-adenosyl-L-homocysteine + 6-methyl thioinosine monophosphate - ? 319828 2.1.1.67 S-adenosyl-L-methionine + 6-thioinosine monophosphate - S-adenosyl-L-homocysteine + 6-methylthioinosine monophosphate - ? 398275 2.1.1.67 S-adenosyl-L-methionine + 6-thioinosine triphosphate - S-adenosyl-L-homocysteine + 6-methylthioinosine triphosphate - ? 456396 2.1.1.67 S-adenosyl-L-methionine + 6-thioinosine-monophosphate - S-adenosyl-L-homocysteine + 6-methylmercaptopurine-ribonucleotide consisting of 6-methyl-thioinosine-monophosphate, -diphosphate and triphosphate ? 398272 2.1.1.67 S-adenosyl-L-methionine + 6-thioinosine-monophosphate - S-adenosyl-L-homocysteine + 6-methylthioinosine-monophosphate - ? 398273 2.1.1.67 S-adenosyl-L-methionine + 6-thiopurine - S-adenosyl-L-homocysteine + 6-methylthiopurine - ? 319794 2.1.1.67 S-adenosyl-L-methionine + 6-thiopurine preferred substrate S-adenosyl-L-homocysteine + 6-methylthiopurine - ? 319794 2.1.1.67 S-adenosyl-L-methionine + 6-thiouric acid - S-adenosyl-L-homocysteine + 6-methylthiouric acid - ? 319800 2.1.1.67 S-adenosyl-L-methionine + 7-methyl-6-mercaptopurine - S-adenosyl-L-homocysteine + ? - ? 319816 2.1.1.67 S-adenosyl-L-methionine + 8-hydroxy-6-mercaptopurine - S-adenosyl-L-homocysteine + 8-hydroxy-6-methylmercaptopurine - ? 319822 2.1.1.67 S-adenosyl-L-methionine + 9(n-propyl)6-thioguanine - S-adenosyl-L-homocysteine + 9(n-propyl)6-methylthioguanine - ? 319797 2.1.1.67 S-adenosyl-L-methionine + 9-(n-butyl)-6-mercaptopurine - S-adenosyl-L-homocysteine + 9-(n-butyl)-6-methylmercaptopurine - ? 319826 2.1.1.67 S-adenosyl-L-methionine + 9-ethyl-6-mercaptopurine - S-adenosyl-L-homocysteine + 9-ethyl-6-methylmercaptopurine - ? 319820 2.1.1.67 S-adenosyl-L-methionine + a thiopurine - S-adenosyl-L-homocysteine + a thiopurine S-methylether - ? 319792 2.1.1.67 S-adenosyl-L-methionine + a thiopurine specific for S-adenosyl-L-methionine S-adenosyl-L-homocysteine + a thiopurine S-methylether - ? 319792 2.1.1.67 S-adenosyl-L-methionine + a thiopurine enzyme plays an important role in metabolism of heterocyclic sulfhydryl drugs such as 6-thiopurine and 6-thioguanine S-adenosyl-L-homocysteine + a thiopurine S-methylether - ? 319792 2.1.1.67 S-adenosyl-L-methionine + a thiopurine S-methylation, enzyme of major catabolic pathway of thiopurines S-adenosyl-L-homocysteine + a thiopurine S-methylether - ? 319792 2.1.1.67 S-adenosyl-L-methionine + azathioprine - ? - ? 398277 2.1.1.67 S-adenosyl-L-methionine + azathioprine azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ? - ? 398278 2.1.1.67 S-adenosyl-L-methionine + azathioprine - S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ? - ? 398278 2.1.1.67 S-adenosyl-L-methionine + azathioprine azathioprine is converted to mercaptopurine, which is subsequently metabolized through TPMT S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ? - ? 398278 2.1.1.67 S-adenosyl-L-methionine + azathioprine - S-adenosyl-L-homocysteine + ? - ? 456417 2.1.1.67 S-adenosyl-L-methionine + mercaptopurine - S-adenosyl-L-homocysteine + methylmercaptopurine - ? 410261 2.1.1.67 S-adenosyl-L-methionine + methanetellurol - S-adenosyl-L-homocysteine + dimethyltelluride - ? 472075 2.1.1.67 S-adenosyl-L-methionine + monomethylseleninic acid - S-adenosyl-L-homocysteine + dimethylseleninic acid - ? 472077 2.1.1.67 S-adenosyl-L-methionine + selenium - S-adenosyl-L-homocysteine + monomethylseleninic acid - ? 474339 2.1.1.67 S-adenosyl-L-methionine + tellurite - S-adenosyl-L-homocysteine + dimethyltelluride - ? 472084 2.1.1.67 S-adenosyl-L-methionine + thioguanine nucleotide - S-adenosyl-L-homocysteine + methylthioguanine - ? 421462 2.1.1.67 S-adenosyl-L-methionine + thioinosine monophosphate - S-adenosyl-L-homocysteine + methylthioinosine monophosphate - ? 410276 2.1.1.67 S-adenosyl-L-methionine + thioinosine triphosphate - S-adenosyl-L-homocysteine + methylthioinosine triphosphate - ? 410277 2.1.1.67 S-adenosyl-L-methionine + thiopurine - S-adenosyl-L-homocysteine + methylthiopurine - ? 410278