2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 - ? 448387 2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 - r 448387 2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 - 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 - ? 448387 2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 activity toward histones in chromatin. SUV39H1 trimethylates H3K9, thereby creating a binding site for HP1, which recruits SUV4-20H. This enzyme generates H4K20me3 using as a substrate the H4K20me1 generated by SET8. Consequently, SUV39H1 indirectly affects the methylation of H4K20 via two pathways: it modifies SET8, thereby enhancing its activity, and creates a site for the binding of SUV4-20H 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 - ? 448387 2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 activity toward histones in chromatin 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 - ? 448387 2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Su(var)3-9 is a di- and trimethyltransferase of H3K9 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 - ? 448387 2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 overall reaction 3 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine9 - ? 448388 2.1.1.355 3 S-adenosyl-L-methionine + biotinylated [histone H3]-L-lysine9 - 3 S-adenosyl-L-homocysteine + biotinylated [histone H3]-N6-methyl-L-lysine9 - ? 449277 2.1.1.355 biotinyl-MARTKQTARKSTGGKAPRKQ + S-adenosyl-L-methionine Dim-5 methylates the histone H3 tail at position Lys9 ? - ? 388239 2.1.1.355 L-lysyl9-[histone H3] + 3 S-adenosyl-L-methionine - N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 3 S-adenosyl-L-homocysteine - ? 458100 2.1.1.355 additional information histone methylation has significant effects on heterochromatin formation and transcriptional regulation ? - ? 89 2.1.1.355 additional information growth factor independent 1 and G9a complex methylates the wild-type H3 substrate as well as the mutants replaced at K4, K36, and K79, substitution at K27 slightly reduces methylation of the H3 substrate, whereas substitution at K9 blocks methylation ? - ? 89 2.1.1.355 additional information minimal substrate methylated by G9a contains seven amino acids (TARKSTG) of the histone H3 tail ? - ? 89 2.1.1.355 additional information the NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance ? - ? 89 2.1.1.355 additional information no activity is observed on trimethylated histone H3(K9) peptides either with or without ubiquitin ? - ? 89 2.1.1.355 additional information the enzyme is automethylated at K239 ? - ? 89 2.1.1.355 additional information the enzyme is able to add methyl groups to lysine 27 as well as 9 in histone H3 ? - ? 89 2.1.1.355 additional information SETDB1 specifically methylates H3K9, but not H3K4 or H3K27. SETDB1 methylates H3 to generate K9me1, K9me2, and K9me3 in a sequential manner ? - ? 89 2.1.1.355 additional information Clr4 automethylates lysines K455 and K472 ? - - 89 2.1.1.355 additional information SUV39H2 also trimethylates LSD1 at K322. SUV39H2 also methylates K134 of H2AX ? - - 89 2.1.1.355 additional information the enzyme also methylates the non-histone substrates SET8 and DOT1L ? - - 89 2.1.1.355 additional information other non-histone substrates of SUV39H1 also have chromatin associated roles: methylation of RAG2 by SUV39H1 occurs within its NLS and it alter its sub-nuclear localization. SUV39H1 can also methylate DOT1L. ? - - 89 2.1.1.355 additional information SUV39H2 is capable of automethylation. The enzyme also methylates the non-histone substrates LSD1 and SUV39H2 ? - - 89 2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 - S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9 - ? 448900 2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 - S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9 - r 448900 2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 - S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 - ? 448906 2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 preferred substrate S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 - ? 448906 2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 - S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 - r 448906 2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 the enzyme introduce H3K9me3 at pericentric heterochromatin S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 - ? 448906 2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 - S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9 - ? 448911 2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 - S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9 - r 448911 2.1.1.355 S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 the enzyme introduce H3K9me3 at pericentric heterochromatin S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9 - ? 448911 2.1.1.355 S-adenosyl-L-methionine + ACINUS - ? - ? 448915 2.1.1.355 S-adenosyl-L-methionine + CDYL1 - ? - ? 448916 2.1.1.355 S-adenosyl-L-methionine + dimethylated histone H3(K9) the activity on dimethylated histone H3(K9) peptides is several folds lower than when monomethylated histone H3(K9) peptides are used S-adenosyl-L-homocysteine + trimethylated histone H3(K9) - ? 419576 2.1.1.355 S-adenosyl-L-methionine + DNA methyltransferase 1 - ? - ? 410220 2.1.1.355 S-adenosyl-L-methionine + H2B ubiquitinated nucleosome - ? - ? 448917 2.1.1.355 S-adenosyl-L-methionine + histone H2A - S-adenosyl-L-homocysteine + ? - ? 410244 2.1.1.355 S-adenosyl-L-methionine + histone H2B - S-adenosyl-L-homocysteine + ? - ? 410247 2.1.1.355 S-adenosyl-L-methionine + histone H3 - ? - ? 389713 2.1.1.355 S-adenosyl-L-methionine + histone H3 (1-13) - ? - ? 389699 2.1.1.355 S-adenosyl-L-methionine + histone H3 (S10phos) phosphorylation of the proximal amino acids impairs Lys-9 methylation via impairing enzyme-substrate interaction ? - ? 389700 2.1.1.355 S-adenosyl-L-methionine + histone H3 (T11phos) phosphorylation of the proximal amino acids impairs Lys-9 methylation via impairing enzyme-substrate interaction ? - ? 389701 2.1.1.355 S-adenosyl-L-methionine + histone H3(K27A) mutation in the unstructured amino-terminal tail of histone H3 does not affect the central globular domain, but reduces the turnover numbers of the substrates ? - ? 389704 2.1.1.355 S-adenosyl-L-methionine + histone H3(K4A) mutation in the unstructured amino-terminal tail of histone H3 does not affect the central globular domain, but reduces the turnover numbers of the substrates ? - ? 389707 2.1.1.355 S-adenosyl-L-methionine + histone H3(K9) - ? - ? 389708 2.1.1.355 S-adenosyl-L-methionine + histone H3(K9) Dim-5 recognizes R8-G12 of the H3 tail with T11 and G12 being the most important specificity determinants, phosphorylation of H3 tail residues S10 and T11may regulate the activity of Dim-5 ? - ? 389708 2.1.1.355 S-adenosyl-L-methionine + histone H3(K9) PRDM8 specifically methylates H3(K9) of histones S-adenosyl-L-homocysteine + ? - ? 410251 2.1.1.355 S-adenosyl-L-methionine + histone H3(K9) SETDB1 is mainly responsible for mono- and trimethylation of histone H3 lysine 9 and SU (VAR)3-9 for monomethylation of histone H3 lysine 9 during spermatogenesis S-adenosyl-L-homocysteine + ? - ? 410251 2.1.1.355 S-adenosyl-L-methionine + histone H4 - S-adenosyl-L-homocysteine + ? - ? 410256 2.1.1.355 S-adenosyl-L-methionine + histone K4-acetylK9 - ? - ? 389714 2.1.1.355 S-adenosyl-L-methionine + histone K4-trimethylK9 - ? - ? 389715 2.1.1.355 S-adenosyl-L-methionine + histone K4AK9 - ? - ? 389716 2.1.1.355 S-adenosyl-L-methionine + histone L-lysine - S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine - ? 319724 2.1.1.355 S-adenosyl-L-methionine + histone L-lysine Lys9 of histone H3 S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine - ? 319724 2.1.1.355 S-adenosyl-L-methionine + histone L-lysine Lys9 of histone 3 S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine - ? 319724 2.1.1.355 S-adenosyl-L-methionine + monomethylated histone H3(K9) the SUVR4 product specificity shifts from di- to trimethylation in the presence of free ubiquitin. SUVR4 in vivo specifically converts monomethylated histone H3(K9) to trimethylated histone H3(K9) at transposons and pseudogenes S-adenosyl-L-homocysteine + trimethylated histone H3(K9) - ? 419586 2.1.1.355 S-adenosyl-L-methionine + p53 the enzyme is responsible for p53 methylation at lysine 373 ? - ? 410267 2.1.1.355 S-adenosyl-L-methionine + reptin the enzyme is responsible for reptin methylation at lysine 67 ? - ? 448918 2.1.1.355 S-adenosyl-L-methionine + WIZ - ? - ? 448919 2.1.1.355 S-adenosyl-L-methionine + [histone H3]-L-lysine9 - S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine9 - ? 448924 2.1.1.355 S-adenosyl-L-methionine + [histone H3]-N6,N6-dimethyl-L-lysine9 - S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine9 - ? 448927 2.1.1.355 S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine9 - S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine9 - ? 448932