3.4.21.B12 adrenal gland high expression level 647334 3.4.21.B12 bone marrow low expression level 647334 3.4.21.B12 brain low expression level, not in fetal brain 647334 3.4.21.B12 breast - 647334 3.4.21.B12 breast carcinoma cell downregulated expression in efussions compared to solid tumors, higher expression as compared to malignant mesothelioma 686322 3.4.21.B12 BT-474 cell - 647334 3.4.21.B12 BT-474 cell breast carcinoma cell line, enzyme is upregulated by progetsins and androgens 647332 3.4.21.B12 CAL-27 cell - 752500 3.4.21.B12 cell culture breast carcinoma cell line 647332 3.4.21.B12 cerebellum low expression level 647334 3.4.21.B12 colon medium expression level 647334 3.4.21.B12 dental pulp - -, 647333 3.4.21.B12 enamel - 686543 3.4.21.B12 enamel from the hard enamel of developing pig teeth 686544 3.4.21.B12 enamel transition-stage developing matrix -, 647333, 647339 3.4.21.B12 endometrial cell line KLK4 endometrial mRNA expression is greatest on days 0, 5, and 10 when compared with days 12, 15, and 17 of the estrous cycle and greater in cyclic compared with pregnant gilts 682813 3.4.21.B12 epithelium epithelial ovarian carcinoma cells 667120 3.4.21.B12 epithelium of enamel organ -, 647333 3.4.21.B12 glandular epithelium co-expression of KLK4 and PAR-2 687699 3.4.21.B12 heart - 680174 3.4.21.B12 HeLa cell - 752370 3.4.21.B12 LNCaP cell - 685946, 717674 3.4.21.B12 LNCaP cell KLK4 mRNA and protein is increased following treatment with conditioned media from SaOs-2 cells 689848 3.4.21.B12 LNCaP cell prostate carcinoma cell line, enzyme is upregulated by androgens 647332 3.4.21.B12 lung low expression level 647334 3.4.21.B12 mammary gland medium expression level 647334 3.4.21.B12 mandibular incisor - 647337 3.4.21.B12 mesothelioma cell mesothelioma cell of both peritoneal and pleural origin express K4, with downregulated expression in efussions compared to solid tumors 686322 3.4.21.B12 molaris the expression of KLK4 is initiated from postnatal day 1 expressed in molar ameloblasts. From postnatal day 5 on, KLK4 is distributed not only in ameloblasts, but also in the degenerating satellite reticulum of molar enamel organ 753881 3.4.21.B12 additional information - 647334 3.4.21.B12 additional information conceptus tissue, KLK4 expression is greatest on day 10 with expression declining after day 14 of gestation 682813 3.4.21.B12 additional information enzyme expression is restricted to developimg teeth -, 647333 3.4.21.B12 additional information enzyme shows a prostate-restricted expression 647336 3.4.21.B12 additional information no expression in stomach, heart, spleen, placenta, liver, pancrease, kidney, skeletal muscle, small intestine 647334 3.4.21.B12 myocardium - 680174 3.4.21.B12 oral squamous cell carcinoma cell KLK4 is differentially expressed in oral carcinomas. OSCC cell lines with high invasive and metastatic potential have the highest levels of KLK4 expression 752500 3.4.21.B12 osteoblast of prostate cancer bone metastases 689848 3.4.21.B12 ovarian carcinoma cell gene overexpression 647332 3.4.21.B12 ovary epithelial ovarian carcinoma cells 667120 3.4.21.B12 ovary cancer cell - 664273, 681390 3.4.21.B12 ovary cancer cell abundance of K4 comparable to that in breast carcinoma, higher expression as compared to malignant mesothelioma 686322 3.4.21.B12 PC-3 cell - 754486 3.4.21.B12 PC-3 cell KLK4 induces loss of PAR-2 from the cell surface and receptor internalisation 687699 3.4.21.B12 PC-3 cell KLK4 mRNA and protein is increased following treatment with conditioned media from SaOs-2 cells 689848 3.4.21.B12 prostate - 647334, 647335 3.4.21.B12 prostate high expression level 647334 3.4.21.B12 prostate restricted expression in hormonally responsive normal and neoplastic epithelial tissue, but not in prostate stromal constituents 647336 3.4.21.B12 prostate specific 647338 3.4.21.B12 prostate cancer cell - 681390, 718348, 731763 3.4.21.B12 prostate cancer cell enzyme expression is regulated by estrogen and progesterone in prostate cancer cells and overexpressed in prostate cancer 668144 3.4.21.B12 prostate cancer cell expression of human kallikrein 1-related peptidase 4 in prostate cancer patients with bone metastasis or advanced stage, immunohistochemic analysis of 62 prostate cancer samples 731893 3.4.21.B12 prostate cancer cell KLK4 is produced exclusively by the epithelial cancer cells 717674 3.4.21.B12 prostate cancer cell of prostate cancer bone metastases 689848 3.4.21.B12 prostate cancer cell line co-expression of agonist and PAR-2 in primary prostate cancer (benign glands of benign prostatic hyperplasia, prostatic intraepithelial neoplasia and cancer) and prostate cancer bone metastasis 687699 3.4.21.B12 prostate cell line KLK4 protein is significantly overexpressed in malignant prostate compared with normal prostate. No significant differences in expression levels among well or poorly differentiated tumors 685946 3.4.21.B12 prostate gland - 680680, 681390, 717674, 718348 3.4.21.B12 prostate gland healthy prostate, highest amount of enzyme 668285 3.4.21.B12 prostate gland predominant expression in basal cells of prostate gland 668144 3.4.21.B12 prostate gland very low enzyme levels in healthy tissue 731893 3.4.21.B12 salivary gland low expression level 647334 3.4.21.B12 SAOS-2 cell KLK4 mRNA and protein is not significantly changed in SaOs2 cells treated with conditioned media from either PC-3 cells or LNCaP cells. KLK4 mRNA is clearly increased following direct co-culture of SaOs2 cells with either PC-3 orLNCaP cells 689848 3.4.21.B12 semen seminal plasma, varying amounts of enzyme 668285 3.4.21.B12 spinal cord medium expression level 647334 3.4.21.B12 testis high expression level 647334 3.4.21.B12 thymus low expression level 647334 3.4.21.B12 thyroid gland high expression level 647334 3.4.21.B12 tooth - 647337, 647339, 680680, 686544 3.4.21.B12 tooth two proteases are secreted into the enamel matrix of developing teeth. The early protease is enamelysin (MMP-20). The late protease is kallikrein 4. Kallikrein 4 is secreted by transition and maturation stage ameloblasts 691154 3.4.21.B12 tooth bud unerupted, incisor -, 647333 3.4.21.B12 trachea low expression level 647334 3.4.21.B12 urine varying amounts of enzyme 668285 3.4.21.B12 uterus expression of KLK4 is more intense in the stroma and uterine epithelium from days 0 to 10 of the estrous cycle 682813 3.4.21.B12 uterus high expression level 647334 3.4.21.B12 WPMY-1 cell - 717674