1.2.1.36 A-549 cell - 762901, 763529, 763530 1.2.1.36 A-549 cell lung cancer 656611 1.2.1.36 adipose tissue - -, 743142 1.2.1.36 alveolar macrophage - 700363 1.2.1.36 amygdala taenial amygdala 675508 1.2.1.36 anterior pituitary - 711854 1.2.1.36 anterior pituitary gland developing pituitary gland 672991 1.2.1.36 arcopallium robust nucleus of the arcopallium, RA 675508 1.2.1.36 astrocyte - 725461 1.2.1.36 bone marrow-derived dendritic cell - 763070 1.2.1.36 brain - 655948, 673325, 675508, 689379, 690142 1.2.1.36 breast - 655948 1.2.1.36 bronchiole - 668500 1.2.1.36 bronchus - 668500 1.2.1.36 cell culture - 677280 1.2.1.36 cerebellar Purkinje cell - 675508 1.2.1.36 commercial preparation recombinant enzyme 762790 1.2.1.36 craniofacial region - 673254 1.2.1.36 dendritic cell - 699331 1.2.1.36 dendritic cell from gut-related lymphoid organs -, 743660 1.2.1.36 dendritic cell isoform RALDH2 is dominantly expressed in dendritic cells 763337 1.2.1.36 diaphragm - 654168 1.2.1.36 duodenum - 690142 1.2.1.36 ectoderm at embryonic day 12.5, RALDH1 mRNA is present in the posterior region of oral ectoderm 672991 1.2.1.36 ectoderm at embryonic day 12.5, RALDH2 mRNA is present in part of the anterior oral ectoderm 672991 1.2.1.36 EKVX cell - 763529 1.2.1.36 embryo - 654553, 672991, 690142, 692481, 692668 1.2.1.36 embryo at 9.5 and 10.5 days of embryonic development the enzyme activity is restricted to tissues of the embryonic trunk and absent in extracts from cranial tissues 655695 1.2.1.36 embryo midgestational 390268 1.2.1.36 embryo RALDH2 activity is present in limiting levels in the early gastrula embryo 711830 1.2.1.36 endocrine pancreas endocrine islets of Langerhans 668500 1.2.1.36 epididymis epididymis capa, epididymis cauda 668500 1.2.1.36 epithelial cell - 668500 1.2.1.36 epithelial cell airway epithelial cell 700363 1.2.1.36 erythrocyte - 655948, 691121 1.2.1.36 exocrine acinar cell pancreas exocrine acini 668500 1.2.1.36 eye - 654700 1.2.1.36 eye in wild-type embryos, RALDH-3 is expressed within the developing eye vesicle in the ventral third of the retina 692668 1.2.1.36 eye in wild-type embryos, the distribution of Raldh-1 is limited to the dorsal third of the eye 692668 1.2.1.36 eye raldh3 mRNA is first expressed in the developing eye region of zebrafish embryos at 10-somite stage. At 24 hpf (hours post fertilization), raldh3 mRNA is expressed in the ventral retina of eye. At 36 hpf, the mRNA is also expressed in otic vesicle in addition to ventral retina, and it maintains its expression pattern till 2 dpf (days post fertilization). At 3 dpf, raldh3 mRNA becomes very weak in ventral retina but is present in otic vesicle at a high level. At 5 dpf and 7 dpf, raldh3 is no longer expressed in eyes but is expressed in otic vesicles at a very low level 692481 1.2.1.36 forebrain - 673254 1.2.1.36 H-1666 cell - 763530 1.2.1.36 H2.35 cell - 673325 1.2.1.36 heart - 673325, 690142 1.2.1.36 heart abundant 686690 1.2.1.36 Hepa-1 cell - 711154 1.2.1.36 hepatocyte - 699951 1.2.1.36 hepatocyte ALDH1A1 protein exhibits diffuse staining in hepatocytes, with greater intensity in the periportal region including surrounding bile ducts 743375 1.2.1.36 hepatoma cell - 763150 1.2.1.36 high vocal center HVC 675508 1.2.1.36 hippocampus - 725461 1.2.1.36 hyperpallium apicale - 675508 1.2.1.36 ileum - 690142 1.2.1.36 interalveolar septum - 668500 1.2.1.36 intestinal epithelial cell isoform RALDH1 is dominantly expressed in intestinal epithelial cells 763337 1.2.1.36 intestinal mucosa - -, 390263 1.2.1.36 intestine raldh4 mRNA is present in developing intestine regions at 2 dpf embryos. Its expression level becomes very high in embryos from 3 dpf to 5 dpf. In 5 dpf embryos raldh4 is expressed in the epithelium of intestine. At 7 dpf, raldh4 mRNA is only weakly expressed in the epithelium of intestinal bulb 692481 1.2.1.36 jejunum - 690142 1.2.1.36 kidney - -, 390271, 655948, 656048, 668500, 673325, 690142, 743142 1.2.1.36 kidney abundant 686690 1.2.1.36 kidney adult mouse 696437 1.2.1.36 kidney mRNA expression most prominent in 2-day-old rats, no activity detected in liver in newborn rats -, 390269 1.2.1.36 kidney tissue with highest content 655948 1.2.1.36 larynx - 668500 1.2.1.36 lens - 390272, 654700, 655948 1.2.1.36 liver - -, 390264, 390265, 390270, 390276, 390277, 655432, 655948, 673242, 673325, 689379, 690142, 693342, 699951, 711154, 742258, 743142, 762688 1.2.1.36 liver adult mouse 696437 1.2.1.36 liver ALDH1A1 is most highly expressed ALDH1 gene in liver 743375 1.2.1.36 liver highest activity 691121 1.2.1.36 liver raldh4 mRNA is present in developing liver regions at 2 dpf embryos. Its expression level becomes very high in embryos from 3 dpf to 5 dpf 692481 1.2.1.36 LNCaP cell expresses endogenous RDH13 at high levels 686690 1.2.1.36 lung - 655948, 690142 1.2.1.36 lung abundant 686690 1.2.1.36 lung intermediate activity 691121 1.2.1.36 lung cancer cell - 763529, 763530 1.2.1.36 macrophage hepatic 743375 1.2.1.36 medial nidopallium - 675508 1.2.1.36 mesenteric lymph node - 699331 1.2.1.36 mesopallium ventrale - 675508 1.2.1.36 additional information ALDH1A1 is highly expressed in lung carcinoma cell line A549 and EKVX, as well as in the large cell carcinoma cell line H460. Isozyme ALDH3A1 (EC 1.2.1.5) shows a similar expression pattern like ALDH1A1. Other members of the aldehyde dehydrogenase family are not expressed in the lung cancer cell lines examined 763529 1.2.1.36 additional information NG2-positive cell 692667 1.2.1.36 additional information no activity in HL-60 cells 762901 1.2.1.36 additional information no activity is detectable in brain, thymus, spleen, kidneys, skeletal muscle and heart 691121 1.2.1.36 additional information no expression of RALDH1 in the rat embryonic pituitary gland 672991 1.2.1.36 additional information present in prolactin (PRL)-producing cells, FS-cells and marginal layer cells. RALDH1 mRNA is not expressed in cells that produce adrenocorticotrophic hormone, GH, thyroid-stimulating hormone, or luteinizing hormone 691692 1.2.1.36 additional information specific expression in embryos and adult reproductive organs 390268 1.2.1.36 mucosa - 655948 1.2.1.36 NCI-H460 cell - 763529 1.2.1.36 NCI-H522 cell - 763530 1.2.1.36 Neuro-2a cell - 673325 1.2.1.36 nucleus isthmo-opticus - 675508 1.2.1.36 oligodendrocyte cell culture 654168 1.2.1.36 ovary - 655948, 668500, 686690, 690142 1.2.1.36 oviduct - 668500 1.2.1.36 P-19 cell - 673325 1.2.1.36 pancreas - 655948, 673242 1.2.1.36 para-high vocal center para-HVC 675508 1.2.1.36 pituitary gland - 711854 1.2.1.36 pituitary gland cell line expression of RALDH2 is located in Rathke's pouch at embryonic day 12.5 and subsequently in the developing anterior pituitary gland. Pituitary RALDH2 mRNA levels are high at E17.5 and decrease markedly after birth 672991 1.2.1.36 pituitary gland cell line expression of RALDH3 is located in Rathke's pouch at embryonic day 12.5 and subsequently in the developing anterior pituitary gland. Pituitary RALDH3 mRNA levels are high at E17.5 and decrease markedly after birth 672991 1.2.1.36 pituitary gland cell line high level of RALDH1 mRNA but not of RALDH2 mRNA or RALDH3 mRNA in anterior pituitary gland of adult rats. RALDH1 mRNA is barely expressed in the embryonic pituitary glands. After birth, RALDH1 mRNA is markedly expressed and gradually increased throughout growth 691692 1.2.1.36 placenta - 690142 1.2.1.36 pleural mesothelium - 668500 1.2.1.36 prostate - 655948, 686690 1.2.1.36 respiratory system - 668500 1.2.1.36 retina - 692668 1.2.1.36 retina photoreceptor inner segments and the outer nuclear layer 694144 1.2.1.36 salivary gland submaxillary gland 668500 1.2.1.36 SAOS-2 cell - 724697 1.2.1.36 skeletal muscle - 655948 1.2.1.36 small intestine - 690142 1.2.1.36 spinal cord brachial spinal cord 673251 1.2.1.36 spinal cord in the uninjured spinal cord low levels of RALDH2 are present in oligodendrocytes as well as in the meninges and in blood vessels 692667 1.2.1.36 stomach - 655948, 690142 1.2.1.36 stromal cell - 677080 1.2.1.36 T-47D cell - 763530 1.2.1.36 TC-1 cell - 763070 1.2.1.36 testis - 390274, 655695, 655948, 686690, 724722 1.2.1.36 testis intermediate activity 691121 1.2.1.36 testis isozyme Aldh1a2 mRNA expression is highest in testis 690142 1.2.1.36 testis tissue with highest content 655948 1.2.1.36 trachea - 668500 1.2.1.36 ureter - 668500 1.2.1.36 urinary bladder - 668500 1.2.1.36 uterine epithelium uterine glandular epithelium 677080 1.2.1.36 uterus - 655695, 677080, 690142