3.1.15.1 additional information enzyme secondary structure molecular modelling 729326 3.1.15.1 additional information the catalytic activity of the enzyme relies on its disulfide bonds and bimetallic cluster 730323 3.1.15.1 physiological function the phosphodiesterase TS-PDE strongly inhibits ADP-induced platelet aggregation in human plateletrich plasma by hydrolyzing ADP 714122