3.1.1.45 physiological function the carboxymethylenebutenolidase homologue is the enzyme responsible for bioactivation of olmesartan medoxomil, prodrug-type angiotensin II type 1 receptor blocker, and also of other prodrug-type angiotensin II type 1 receptor blockers, candesartan cilexetil and azilsartan medoxomil 729630 3.1.1.45 physiological function the carboxymethylenebutenolidase homologue is the enzyme responsible in humans for bioactivation of olmesartan medoxomil, prodrug-type angiotensin II type 1 receptor blocker 729629 3.1.1.45 physiological function the carboxymethylenebutenolidase homologue is the enzyme responsible in humans for bioactivation of olmesartan medoxomil, prodrug-type angiotensin II type 1 receptor blocker, and also of other prodrug-type angiotensin II type 1 receptor blockers, candesartan cilexetil and azilsartan medoxomil -, 729630 3.1.1.45 physiological function the hydrolysis of dienelactone plays a key role for the microbial degradation of chloroaromatics via chlorocatechols -, 714312