2.8.3.5	malfunction	insulinoma cell lines with more than 70% knockdown of enzyme activity shows more than 70% reduction in glucose- or methyl succinate-plus-beta-hydroxybutyrate-stimulated insulin release	724109	
2.8.3.5	malfunction	loss of succinyl-CoA:3-ketoacid CoA transferase protein in aged rats may attenuate the capacity of kidney mitochondria to utilize ketone bodies for energy production	703810	
2.8.3.5	malfunction	overexpression of OXCT1 enhances sensitivity to cisplatin in the SK-OV-3 OC cell line	762068	
2.8.3.5	malfunction	succinyl-CoA:3-ketoacid CoA transferase deficiency is an inborn error of ketone body metabolism and causes episodic ketoacidosis	724424	
2.8.3.5	metabolism	SCOT is a key enzyme involved in ketone body metabolism	705310	
2.8.3.5	metabolism	SCOT is a rate-limiting enzyme in the degradation of ketone bodies	703810	
2.8.3.5	additional information	low enzyme expression is correlated with diabetis type 2	703384	
2.8.3.5	physiological function	3-oxoacid-CoA transferase 1 (OXCT1) is a homodimeric mitochondrial matrix enzyme that serves a central role in extrahepatic ketone body catabolism (ketone bodies to acetyl-CoA to mitochondrial tricarboxylic acid cycle entrance). OXCT1 overexpression in a cisplatin-resistant cell line improves sensitivity to cisplatin. Natural sensitivity to cisplatin is observed in the eight human ovarian cell lines SK-OV-3, PA-1, Caov-3, TOV-21 G, TOV-112D, OV-90, OVCAR-3 and A2780	762068	
2.8.3.5	physiological function	loss of SCOT protein in the aged rats may attenuate the capacity of kidney mitochondria to utilize ketone bodies for energy production	703810	
2.8.3.5	physiological function	role of SCOT in insulin secretion	703384