2.5.1.16	malfunction	an enzyme-deficient strain is auxotrophic for polyamines, requires spermidine for growth in its insect vector form, and is adversely impacted in its ability to infect mice	-, 722385	
2.5.1.16	malfunction	deletion of SpeE does not affect flagellar formation, but induces clockwise rotation bias	759788	
2.5.1.16	malfunction	maternal loss of spermidine synthase leads to lethality and defects in pancreas development	758872	
2.5.1.16	malfunction	microarray experiments with a spermidine synthase, spermine oxidase mutant (DELTAspe3DELTAfms1) strain are performed to investigate the responsiveness of yeast genes to supplementation with spermidine or spermine. Expression analysis identified genes responsive to the addition of either excess spermidine or spermine compared to a control culture. Results from global gene expression profiling demonstrate a more major role for spermidine in modulating gene expression in yeast than spermine	706926	
2.5.1.16	malfunction	single spe-sdh mutants are isolated after sexual recombination in planta with a compatible wild-type strain. Mutants are auxotrophic for lysine and spermidine, but not for putrescine, and contain putrescine and spermidine, but not spermine. spe-sdh are were sensitive to stress, unable to carry out the yeast-to-mycelium dimorphic transition, and show attenuated virulence to maize. These phenotypic alterations are reverted by complementation with the wild-type gene	703771	
2.5.1.16	malfunction	the growth of the spds knockout DELTAspds is completely inhibited when cells are grown in the presence of 400 mM sorbitol	-, 759098	
2.5.1.16	metabolism	spermidine synthase is a key enzyme for polyamine biosynthesis	723048	
2.5.1.16	metabolism	the enzyme catalyzes the production of the linear triamine, spermidine, from putrescine	759264	
2.5.1.16	additional information	homozygous overexpressing transgenic tomato plant lines show a high level of Md-SPDS1 mRNA expression and a 1.5 to 2fold increase in the levels of free spermidine in fruits compared to the wild-type plants. Analysis of pericarp-columella and metabolites in placenta tissues reveal distinct metabolic profiles between the wild-type and transgenic lines, particularly at the late ripening stages, phenotypes, overview. The transgenic tomato fruits also show an increase in carotenoid accumulation, especially in lycopene, and increased ethylene production compared to wild-type fruits. Genes responsible for lycopene biosynthesis, including phytoene synthase, phytoene desaturase, and deoxy-D-xylulose 5-phosphate synthase, are significantly up-regulated in ripe transgenic fruits, whereas genes involved in lycopene degradation, including lycopene-epsilon cyclase and lycopene beta cyclase, are downregulated in the transgenic fruits compared to the wild-type	723048	
2.5.1.16	additional information	ligand docking modeling using the tertiary structure model, overview	721733