2.5.1.101	evolution	the gene encoding the enzyme shows homology to known sialic acid biosynthetic gene neuB	-, 718850	
2.5.1.101	metabolism	the enzyme is involved in the the Leg pathway, which is essential for the biosynthesis of CMP-N,N'-diacetyllegionaminate, that acts as a donor substrate with a selection of bacterial and mammalian sialyltransferases	718948	
2.5.1.101	metabolism	the enzyme is part of the biosynthesis of legionaminic acid and its CMP-activated form, metabolite determination and identification by NMR spectroscoopy for pathway construction and analysis, overview	-, 719563	
2.5.1.101	metabolism	the three enzymes, UDP-N,N'-diacetylbacillosamine 2-epimerase, N,N'-diacetyllegionaminic acid synthase, and CMP-N,N'-diacetyllegionaminic acid synthetase, constitute a pathway that converts a UDP-linked bacillosamine derivative into a CMP-linked legionaminic acid derivative, the activated form of legionaminic acid used in lipopolysaccharide biosynthesis, overview	-, 718850	
2.5.1.101	additional information	NeuB can be substituted by NanA from Escherichia coli, a sialic acid aldolase that catalyzes the condensation of 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose with pyruvate resulting in N,N'-diacetyllegionaminate formation, ability of sialyltransferases to utilize the CMP-N,N'-diacetyllegionaminate donor, overview	718948