1.6.3.4 malfunction the inability of the nox2 mutant to grow aerobically is mainly due to an underlying defect in fatty acid biosynthesis. NAD+ depletion in the nox2 mutant results in reduced acetyl-CoA production, which perturbs fatty acid biosynthesis and hence blocks growth in aerobiosis 723206 1.6.3.4 metabolism the enzyme can regulate the metabolism during aerobic fermentation in Saccharomyces cerevisiae, thereby protecting cells against several stresses -, 742579 1.6.3.4 physiological function the enzyme is essential for aerobic growth and oxidative stress resistance in conventional culture media. The enzyme facilitates adaptation of group B Streptococci to aerobic conditions encountered during infection 723206 1.6.3.4 physiological function the enzyme is involved in oxygen metabolism -, 721336