1.5.8.4	malfunction	rare natural mutation H109R, causes dimethylglycine dehydrogenase deficiency leading to increased blood and urinary dimethylglycine concentrations	742499	
1.5.8.4	metabolism	the enzyme takes part in choline degradation, one-carbon metabolism and electron transfer to the respiratory chain	742499	
1.5.8.4	metabolism	the phosphorylation of Akt-308/473 is significantly suppressed when the enzyme is overexpressed	743378	
1.5.8.4	physiological function	dimethylglycine dehydrogenase expression suppresses metastasis through the Akt signaling pathway	743378	
1.5.8.4	physiological function	DMGDH suppresses migration, invasion and metastasis both in vitro and in vivo. In a DMGDH over-expressing cell line, the phosphorylation of Akt-308/473 is significantly suppressed	743378	
1.5.8.4	physiological function	during the process of intestine regeneration, there are significant differences in metabolism between regenerative intestines at 3, 7, and 14 days post evisceration and normal intestines. Genes encoding betaine-aldehyde dehydrogenase, betaine-homocysteine S-methyltransferase 1, and dimethylglycine dehydrogenase are differentially expressed to regulate the levels of betaine and N,N-dimethylglycine during intestine regeneration	764528	
1.5.8.4	physiological function	the enzyme suppresses metastasis in hepatocellular carcinoma	743378