1.2.7.1	malfunction	resistance to metronidazole is associated with enzyme down-regulation	725220	
1.2.7.1	metabolism	anaerobic fermentative metabolism of glycerol. Proteome analysis as well as enzyme assays performed in cell-free extracts demonstrate that glycerol is degraded via glyceraldehyde-3-phosphate, which is further metabolized through the lower part of glycolysis leading to formation of mainly ethanol and hydrogen	748573	
1.2.7.1	metabolism	the enzyme is involved in catabolism of pyruvate	-, 744835	
1.2.7.1	physiological function	Archaeoglobus fulgidus strain 7324 converts starch to acetate via a modified Embden-Meyerhof pathway and acetyl-CoA synthetase (ADP-forming)	-, 721449	
1.2.7.1	physiological function	first enzyme of pyruvate catabolism	-, 288448	
1.2.7.1	physiological function	in a cytosolic hydrogenase-deficient strain, pyruvate:ferredoxin oxidoreductase POR and 2-oxoisovalerate:ferredoxin oxidoreductase VOR specifically function in oxidation of pyruvate and branched-chain amino acids, respectively, and the lack of POR or VOR is compensated for by promoting the oxidation of another substrate driven by the remaining oxidoreductase	736364	
1.2.7.1	physiological function	in autotrophic methanogens, pyruvate oxidoreductase plays a key role in the assimilation of CO2 and the biosynthesis of organic carbon	-, 654391	
1.2.7.1	physiological function	PFOR is translated after the second phase of the excystation process	711368	
1.2.7.1	physiological function	pyruvate ferredoxin oxidoreductase, encoded by PforA, plays a key role in pyruvate dissimilation. Although the pfl gene encoding pyruvate formate-lyase is normally expressed at low levels, it is crucial for biosynthesis in Thermoanaerobacterium saccharolyticum. In pforA deletion strains, pfl expression increases and is able to partially compensate for the loss of pyruvate ferredoxin oxidoreductase activity. Deletion of both pforA and pfl results in a strain that requires acetate and formate for growth and produces lactate as the primary fermentation product, achieving 88% theoretical lactate yield	-, 735819	
1.2.7.1	physiological function	the enzyme is a surface-associated cell-binding protein that lacks enzyme activity and is involved in cytoadherence to host cells	725907