1.14.14.94 metabolism CYP4F catalyzes the omega-hydroxylation of the side chain of tocopherols and tocotrienols, the first step in their catabolism to polar metabolites excreted in urine. CYP4F2 is the only enzyme currently shown to metabolize vitamin E in humans 712833 1.14.14.94 physiological function by regulating the balance of leukotriene B4 in the lung, LTB4OH may function as a suppressor of lung carcinogenesis 703013 1.14.14.94 physiological function CYP4F3B plays a central role in the inactivation and elimination of leukotrienes from systemic circulation during the resolution of inflammation 741555 1.14.14.94 physiological function is critical in the inactivation of leukotriene B4 in polymorphonuclear leukocytes with a -fold induction between 3 and 71 703413