1.14.11.61 physiological function biosynthetic steps of scopoletin synthesis in roots suffering from post-harvest physiological deterioration, when secondary metabolites accumulate. Amongst these are hydroxycoumarins which play roles in plant defence and have pharmacological activities 751826 1.14.11.61 physiological function enzyme is involved in scopoletin synthesis. Young leaves Nicotiana attenuata, are more resistant to Alternaria alternata infection than mature leaves, and this is correlated with stronger blue fluorescence emitted by scopoletin and its beta-glycoside form, scopolin. Silencing of F6'H1 reduces scopoletin levels and plant resistance against Alternaria alternata 751220 1.14.11.61 physiological function T-DNA insertion mutants of F6'H1 show severe reductions in scopoletin and scopolin levels in the roots. The pattern of F6'H1 expression is consistent with the patterns of scopoletin and scopolin accumulation 751858 1.14.11.61 physiological function the gene expression level of the feruloyl-CoA 6'-hydroxylase 1 is highly elicited plants after inoculation with Alternaria alternata. Silencing inositol-requiring enzyme IRE1 or transcription factor bZIP60 leads to Nicotiana attenuata plants more susceptible to Alternaria alternata, which are associated with reduced gene expressions of feruloyl-CoA 6'-hydroxylase 1 764778 1.14.11.61 physiological function transgenic lines for cassava genes, F6'H1, F6'H2, and F6'H3 are able to complement homozygous Arabidopsis T-DNA insertion mutants and accumulate high levels of scopoletin in their roots 765582