1.1.1.290	metabolism	pyridoxal phosphate biosynthesis in Escherichia coli is quite different from the more widely used Pdx1/Pdx2-dependent pathway. Escherichia coli uses seven enzymes in a bifurcated pathway that converts pyruvate, glyceraldehyde-3-phosphate, and erythrose-4-phosphate to pyridoxal phosphate via the intermediates 1-deoxy-D-xylulose 5-phosphate and 1-amino-propan-2-one-3-phosphate. PdxB catalyzes the second step in the biosynthesis of pyridoxal phosphate by oxidizing 4-phospho-D-erythronate to 2-oxo-3-hydroxy-4-phospho-butanoate with concomitant reduction	-, 724295	
1.1.1.290	physiological function	the pdxB gene, encoding erythronate-4-phosphate dehydrogenase, is required for de novo vitamin B6 biosynthesis. Mutation in pdxB causes growth deficiency of Photorhabdus luminescens in nutrient-poor medium, which is restored under nutrient-rich conditions or by supplementation with pyridoxal 5'-phosphate. Supplementation with pyridoxal, pyridoxine, and pyridoxamine also restores the growth of the pdxB mutant. Supplementation with pyridoxal 5'-phosphate restores the virulence-deficient phenotype against Caenorhabditis elegans	-, 739912