4.1.99.19 physiological function involved in the biosynthesis of the thiazole moiety of thiamine 715007 4.1.99.19 physiological function the enzyme complex ThiGH is involved in the rate-limiting step of thiamine biosynthesis 715465 4.1.99.19 physiological function the enzyme is essential for thiazole biosynthesis in Escherichia coli 715486 4.1.99.19 physiological function the enzyme is required for the synthesis of the 4-methyl-5-hydroxyethyl-thiazole monophosphate moiety of thiamine diphosphate 715471