3.1.3.78	additional information	phosphatidylinositol 5-phosphate may play a sensor function in setting the threshold of T-cell activation and contributing to maintain T-cell homeostasis	715020	
3.1.3.78	physiological function	PtdIns(4,5)P2 4-phosphatase expression induces Src kinase and Akt, but not ERK activation and enhances interleukin II promoter activity in T-cells. Expression of a PtdIns5P interacting domain, PH-Dok-5, blocks IpgD-induced T-cell activation and selective signaling molecules downstream of TCR triggering, evaluation, overview	715020