2.5.1.21	evolution	phylogenetic analysis of SQS enzymes in plants shows highly similar conserved pattern including 77DTVED81 and 213DYLED217 motifs, which are rich in aspartic acids involved in FPP binding	739735	
2.5.1.21	evolution	the enzyme belongs to the isoprenoid biosynthesis enzymes class 1 superfamily	-, 738798	
2.5.1.21	malfunction	enzyme overexpression in transgenic Withania somnifera plants affects the shoot elongation and multiplication, phenotype, overview	739290	
2.5.1.21	malfunction	Inhibition of squalene synthase leads directly to a reduction in cholesterol biosynthesis and thus to a fall in plasma cholesterol levels. Plasma LDL-cholesterol and triglycerides are lowered by squalene synthase inhibitors	721802	
2.5.1.21	malfunction	modifications in region IV prevents SQS from undergoing the second half-reaction, indicating that this region may reasonably constitute a functional NADPH binding site	722759	
2.5.1.21	malfunction	the SQS inhibitors YM-53601 and zaragozic acid A decrease hepatitis C virus RNA, protein, and progeny production in HCV-infected cells without affecting cell viability, using the HCV JFH-1 strain and human hepatoma Huh-7.5.1-derived cells. siRNA-mediated knockdown of SQS leads to significantly reduced HCV production, confirming the enzyme acts as an antiviral target. A metabolic labeling study demonstrates that enzyme inhibitor YM-53601 suppresses the biosynthesis of cholesterol and cholesteryl esters at antiviral concentrations	738940	
2.5.1.21	metabolism	enzyme SQS operates at a branch point of the withanolide biosynthetic pathway regulating the metabolic flux and catalyzes the first committed step leading to the synthesis of different withanolides	739290	
2.5.1.21	metabolism	four major steps - substrate binding, condensation, intermediate formation and translocation - of the ordered sequential mechanisms involved in the 1'-1 isoprenoid biosynthetic pathway	737345	
2.5.1.21	metabolism	key enzyme in the isoprenoid pathway	706801	
2.5.1.21	metabolism	part of cholesterol biosynthesis pathway	703278