2.3.1.176 evolution HaSCP-x/SCP-2 is a member of the SCP-2 gene family 720169 2.3.1.176 evolution the MsSCP-x/SCP-2 protein has a high degree of homology in the SCP-2 domain to other insect SCP-2 719181 2.3.1.176 malfunction disruption of either TgACBP1 (acyl-CoA binding protein) or TgSCP2 caused no obviously phenotypic changes, whereas double disruption results in defects in intracellular growth and virulence to mice. TgACBP1 or TgSCP2 disruption alone leads to decreased abundance of C18:1, whereas double disruption results in reduced abundance of C18:1, C22:1, and C24:1. Loss of TgACBP1 and TgSCP2 cause serious defects in production of glycerides and phospholipids. Collectively, TgACBP1 and TgSCP2 play synergistic roles in lipid metabolism in Toxoplasma gondii 756412 2.3.1.176 malfunction scp2 mutants are strongly attenuated in virulence and this defect manifested itself during penetration. Deletion of scp2 in Ustilago maydis interfers neither with growth nor with peroxisomal beta-oxidation 757822 2.3.1.176 additional information effects of dsRNA interference of HaSCP-x/SCP-2 transcripts on larval development and fecundity in adults, overview 720169 2.3.1.176 physiological function HaSCPx/2 gene is important for normal development and fertility in Helicoverpa armigera 720169 2.3.1.176 physiological function inhibitor-treated larvae at young stage show a significant decrease of cholesterol uptake in vivo 737254 2.3.1.176 physiological function knockdown of scp2 does not interfere with the patterning of the kidney along its proximo-distal axis, but dramatically decreases the size of the kidney, in particular the proximal tubules. This phenotype is accompanied by a reduction of lipid rafts, but is independent of the peroxisomal or transcriptional activities of scp2. Disrupting lipid microdomains by inhibiting cholesterol synthesis phenocopies the defects seen in scp2 morphants 735998 2.3.1.176 physiological function MsSCP-2 may function as a lipid carrier protein in vivo, MsSCP-2 is involved in cholesterol uptake in vivo, overview 719181 2.3.1.176 physiological function overexpression enhances cholesterol uptakeinto Spli-221 cells 702910