2.1.1.67	evolution	Callithrix jacchus thiopurine S-methyltransferase (TPMT) is phylogenetically closer to other primate orthologs than to its pig, dog, rabbit, or rodent orthologs	777173	
2.1.1.67	evolution	Callithrix jacchus thiopurine S-methyltransferase (TPMT) is phylogenetically closer to other primate orthologs than to its pig, dog, rabbit, or rodent orthologs. Callithrix jacchus and human TPMT are similar at the molecular level	777173	
2.1.1.67	malfunction	intermediate and low enzyme activity may lead to leukopenia following thiopurine treatment	733706	
2.1.1.67	malfunction	when thiopurine methyltransferase protein activity is low a greater degree of cytotoxicity and DNA damage can occur after thioguanine exposure	720847	
2.1.1.67	metabolism	thiopurine drugs, azathioprine, mercaptopurine, and thioguanine, are widely used in the treatment of several malignant and nonmalignant diseases. Patients with low-activity variants of thiopurine S-methyltransferase can be affected by pronounced pharmacologic effects when receiving thiopurine medications	778459	
2.1.1.67	additional information	a method used to determine thiopurine S-methyltransferase activity by measuring 6-MMP by liquid chromatography-tandem mass spectrometry while employing 6-methylmercaptopurine-d3 as an internal standard	778459	
2.1.1.67	additional information	the enzyme plays roles in the metabolism of widely used anticancer and anti-inflammatory drugs	777173	
2.1.1.67	physiological function	both thiopurine S-methyltransferase (TPMT) and indolethylamine N-methyltransferase (INMT) cooperatively contributed to the trimethylselenonium ion production, enabling urinary excretion of Se and maintenance of homeostasis of this essential yet highly toxic trace element. Thus, TPMT and INMT can be recognized as selenium methyltransferases	777027	
2.1.1.67	physiological function	thiopurine S-methyltransferase and indolethylamine N-methyltransferase are cooperatively responsible for the detoxification of Tellurium oxyanions through methylation to form trimethyltelluronium ions	776531