1.14.18.7	physiological function	Arabidopsis thaliana Bax inhibitor-1 -mediated suppression of cell death in yeast requires Saccharomyces cerevisiae fatty acid hydroxylase 1, which has a Cb5-like domain at the N terminus and interacts with Bax inhibitor-1	734909	
1.14.18.7	physiological function	expression of Arabidopsis thaliana FAH1 gene, which does not contain the cytochrome b5 domain, in the Saccharomyces cerevisiae DELTAfah1 strain produces an approximately 25fold increase in alpha-hydroxyfatty acid 26:0 and reduces the levels of its 26-carbon precursor	734124	
1.14.18.7	physiological function	interaction with Arabidopsis cytochrome b5 is needed for sufficient activity. Isoform FAH1 mainly 2-hydroxylates very-long-chain fatty acids. In FAH1 knock-down lines, levels of hydroxylated fatty acids 22:0, 24:0, and 26:0 are considerably lower than in wild type, whereas the level of hydroxylated fatty acid 16:0 is marginally decreased. 2-Hydroxyfatty acids are related to resistance to oxidative stress, and isoform FAH1 or 2-hydroxy very-long-chain fatty acids show particularly strong responses to oxidative stress. Isoform FAH1 interacts with Bax inhibitor-1 via cytochrome b5 and is a key factor in Bax inhibitor-1-mediated cell death suppression	734960	
1.14.18.7	physiological function	interaction with Arabidopsis cytochrome b5 is needed for sufficient activity. Isoform FAH2 selectively 2-hydroxylates palmitic acid in Arabidopsis. In FAH2 knock-down lines, the level of hydroxylated fatty acid 16:0 is reduced by 22.9%, whereas the levels of other 2-hydroxyfatty acids are similar to those in wild type	734960