1.14.14.B10 physiological function coculture of ChuS-overexpressing Escherichia coli with bone marrow derived macrophages results in decreased IL-12 p40 and increased IL-10 secretion compared to wild-type or ChuS-deficient Escherichia coli. Mice infected with ChuS-overexpressing Escherichia coli have increased levels of hepatic carbon monoxide and decreased serum IL-12 p40 -, 745713