4.2.3.104	metabolism	alpha-humulene synthase is a key enzyme of zerumbone biosynthesis	718244	
4.2.3.104	metabolism	the enzyme is involved in the biosynthetic pathways for sesquiterpenes found in agarwood and cell suspension cultures, putative pathway, overview. Various post-transcriptional, translational, or post-translational regulatory mechanisms affecting the expression or activity of alpha-humulene and delta-guaiene synthases are possible	748440	
4.2.3.104	metabolism	the enzyme is involved in the zerumbone biosynthesis in Zingiber zerumbet, proposed pathway and mechanism, overview	746789	
4.2.3.104	additional information	sesquiterpene synthase alpha-humulene synthase (HUM) from Zingiber zerumbet is investigated for the bioconversion of the monoterpene precursors geranyl diphosphate (2E-GPP) and neryl diphosphate (2Z-NPP) as well as for the sesquiterpene precursor farnesyl diphosphate (2E,6E-FPP)	747656	
4.2.3.104	additional information	the enzyme contains conserved RPx8W motif and DDxxD motif, which is a divalent metal-ion substrate-binding site	748440	
4.2.3.104	physiological function	after tobacco rattlevirus-based virus induced gene silencing, beta-elemene, guaia-1(5),11-diene and guaia-1(10),11-diene are undetectable in suppressed leaves	730575	
4.2.3.104	physiological function	alpha-humulene is a common sesquiterpene widely distributed in plants, the synthase from Zingiber zerumbet is the only known sesquiterpene synthase to date catalyzing the formation of alpha-humulene as major product	746789