2.5.1.108	malfunction	loss of Dph4 results in lack of diphthamide modification of eEF2 and resistance to diphtheria toxin. Dph4 mutant mice are growth retarded and have a specific digit defect with one or more additional preaxial digits	725594	
2.5.1.108	malfunction	mutation in DPH2 blocks diphthamide biosynthesis	718109	
2.5.1.108	physiological function	diphthamide biosynthesis proteins Dph1 and Dph2 interact and the first step of diphthamide formation on eukaryotic translation elongation factor eEF2 requires a complex formed in vivo between Dph1, Dph2 and Dph3	739730	
2.5.1.108	physiological function	first step of diphthamide biosynthesis, a unique posttranslational modification on a histidine residue of translational elongation factor 2	723158	
2.5.1.108	physiological function	required for diphthamide biosynthesis	718109	
2.5.1.108	physiological function	the enzyme is involved in diphthamide biosynthesis	718109, 723263