2.3.1.219 evolution the enzyme belongs to the Type III polyketide synthase family 2.3.1.219 evolution the enzyme belongs to the Type III polyketide synthase family. A Cys-His-Asn catalytic triad is conserved in all known type III PKSs 2.3.1.219 metabolism the enzyme catalyzes a step in the curcuminoid biosynthesis, pathway overview 2.3.1.219 additional information CURS can collaborate with curcumin synthase, DCS, EC 2.3.1.218, which provides the substrate feruloylacetyl-CoA from condensation of feruloyl-CoA and malonyl-CoA, overview