1.2.1.16	metabolism	GABA metabolism	698627	
1.2.1.16	metabolism	succinic semialdehyde dehydrogenase (SSADH) catalyzes the oxidation of succinic semialdehyde (SSA) into succinic acid in the final step of gamma-aminobutyric acid degradation	-, 743077	
1.2.1.16	metabolism	succinic semialdehyde dehydrogenase (SSADH) catalyzes the oxidation of succinic semialdehyde to succinic acid in the final step of GABA catabolism	743290	
1.2.1.16	metabolism	the enhanced production of 2-oxoglutarate (KG) effected by Pseudomonas fluorescens in a mineral medium supplemented with manganese (Mn) is propelled by the increased activities of succinate semialdehyde dehydrogenase (SSADH), gamma-aminobutyric acid aminotransaminase (GABAT), and isocitrate lyase (ICL). The latter generates glyoxylate and succinate two key metabolites involved in this process. Fumarate reductase (FRD) also aids in augmenting the pool of succinate, a precursor of succinate semialdehyde (SSA). The latter is then carboxylated to KG with the assistance of 2-oxoglutarate decarboxylase (KDC)	-, 763073	
1.2.1.16	additional information	the conserved Cys262 and Glu228 residues are crucial for the catalytic activity of cce4228 protein and the Ser157 and Lys154 residues are determinants of cofactor preference. The Cys residue is thought to function as a nucleophile in the catalytic mechanism. Homology structure modeling of wild-type cce4228 protein	-, 763626	
1.2.1.16	physiological function	enzyme GabD irreversibly oxidizes D-glyceraldehyde 3-phosphate (Ga3P) to 3-phospho-D-glycerate (3Pglycerate) using NAD+ or NADP+, thus resembling a non-phosphorylating Ga3PDHase (EC 1.2.1.90). But the enzyme shows about 6fold higher Km value and three orders of magnitude higher catalytic efficiency with succinate semialdehyde (SSA) and NADP+. Indeed, the GabD protein identity corresponds to an SSA dehydrogenase (SSADHase). As an SSADHase, GabD physiologically acts producing succinate and preferentially NADPH over NADH, thus being part of an alternative pathway of the tricarboxylic acid cycle converting alpha-ketoglutarate to succinate	-, 762770