1.1.1.69 malfunction the disruption of the gene, gluF, by CRISPR/Cas9 in the filamentous fungus Aspergillus niger results in a strain unable to catabolise D-glucuronate 1.1.1.69 metabolism the enzyme is involved in the pathway for D-glucuronate catabolism in fungi 1.1.1.69 physiological function the enzyme prevents the formation of ectopic Z rings during Streptococcus suis cell division and plays a role in septum constriction 1.1.1.69 physiological function gene disruption results in a strain unable to catabolise D-glucuronate. A pathway for D-glucuronate catabolism is suggested with the intermediates L-gulonate, 2-keto-L-gulonate, L-idonate, 5-keto-D-gluconate, D-gluconate and D-gluconate-6-phosphate