2.4.2.7	down	the gene encoding adenine phosphoribosyltransferase (APRT) is downregulated by 5.2fold in the parasites resistant against benznidazole (Bz) and nifurtimox (Nfx), and its expression profile is confirmed by 2D electrophoresis analysis	-, 759538	
2.4.2.7	additional information	mutational HPRT deficiency leads to increased APRT expression and activity in MN9D cells, microarray analysis of HPRT-deficient MN9D cells, phenotype with increases in APRT and mRNAs for engrailed 1 and 2, En1 and En2, transcription factors, overview	703955	
2.4.2.7	up	overexpression of APRT (pTREX-APRT) in benznidazole sensitive parasites, relative to the control parasites transfected with GFP (pTREX-GFP), confirmed by quantitative RT-PCR and northern blot analysis. 15.6fold and 4.6fold overexpressions are detected for the two different techniques, respectively	-, 759538