2.3.1.B41	down	SIRT6 is down-regulated in human glioma tissues	729145	
2.3.1.B41	down	H2O2 treatment significantly reduces Sirt6 protein. Stress-induced downregulation of Sirt6 is likely involved in the pathogenesis of diabetic retinopathy	729362	
2.3.1.B41	up	SIRT6 is upregulated in squamous cell carcinoma	729520	
2.3.1.B41	down	decline of SIRT6 expression when bladder cancer progresses from stage T2 to stage T4	729849	
2.3.1.B41	down	in cortical and hippocampal neurons SIRT6 is downregulated during maturation in vitro, reaching the lowest expression at 11 days in vitro	730473	
2.3.1.B41	up	during mitosis, the Sirt6 expression level is increased	730527	
2.3.1.B41	up	enzyme expression in HCC cells is upregulated by transforming growth factor-beta1, H2O2, and HOCl	737977	
2.3.1.B41	down	enzyme expression is significantly reduced in human ovarian cancer tissues compared to the normal tissues	738169	
2.3.1.B41	up	SIRT6 expression is upregulated under pathologic conditions in angiotensin II-stimulated cardiac fibroblasts and in myocardium of rat subjected to abdominal aortic constriction surgery	739733	
2.3.1.B41	up	inhibition of SIRT5 significantly promotes SIRT6 expression	755904