1.8.98.2	down	disruption of Nrf2 signaling down-regulates the expression of Srx1	
1.8.98.2	up	Nrf2, nuclear factor erythroid-2-related factor, up-regulates Srx1 expression during oxidative stress caused by cigarette smoke exposure in the lungs	
1.8.98.2	up	oxidative stress and growth factors can markedly upregulate Srx transcript and protein levels	
1.8.98.2	up	adrenocortical tumor cell lines show increased enzyme expression. Adrenocorticotropic hormone also induces upregulation of the enzyme with its levels peaking at 3-6 h after injection of adrenocorticotropic hormone	
1.8.98.2	up	high glucose induces enzyme expression	
1.8.98.2	up	under the oxidation stress elicited by hydrogen peroxide, the transcription level of AtSrx is significantly increased