1.14.19.47 down the FADS2 gene expression regulated by dietary fatty acids is significantly negatively correlated with the methylation rate of putative FADS2 gene promoter 746258 1.14.19.47 up after adriamycin treatment, enzyme activity increases in polyenylphosphatidylcholine-fed and trilinolein-fed rats 734532 1.14.19.47 up expression of DELTA6fad is significantly affected by dietary lipid and, especially, fatty acid composition, with highest expression of mRNA in liver of fish fed a diet with a ratio of 18:3n-3/18:2n-6 of 1.72:1 746261 1.14.19.47 up liver gene expression of FADS2 is up-regulated in groups enriched in C16:0, C18:0 and C18:1n-9 respectively but not in the group enriched in C18:3n-3 compared to groups with high n-3 LC-PUFA contents 746258 1.14.19.47 up neuronal differentiation of Y-79 cells causes a great increase in enzyme activity 733370 1.14.19.47 up replacement of fish oil with linseed oil increases the expression of DELTA6 fad mRNA in liver, muscle and intestine but no significant difference is found in the brain 744748