1.14.11.7 down the expression of P3H2 , or Leprel1, but not of P3H1 or Leprecan, is specifically downregulated in breast cancer by abberrant CpG methylation in the 5' regulatory sequences of the genes. Methylation of P3H2 is strongly associated with estrogen-receptor-positive breast cancers 1.14.11.7 down the expression of P3H3, or Leprel2, but not of P3H1 or Leprecan, is specifically downregulated in breast cancer by abberrant CpG methylation in the 5' regulatory sequences of the genes. Methylation of P3H3 is not associated with estrogen-receptor-positive breast cancers, while P3H3 isassociated with higher tumour grade and Nottingham prognostic index 1.14.11.7 up after apoptosis of H9c2 cells is induced by DOX, PHD3 expression is upregulated in a time-dependent manner, whereas the expression of PHD1 or PHD2 is constant 1.14.11.7 up TNF-alpha and IL-1beta robustly increase PHD3 expression in an NF-kappaB dependent fashion